In silico discovery of the dormancy regulons in a number of Actinobacteria genomes
Description:
Mycobacterium tuberculosis is a dangerous Actinobacteria infecting nearly one third of the human population. It becomes dormant and phenotypically drug resistant in response to stresses. An important feature of the M. tuberculosis pathogenesis is the prevalence of latent infection without disease, making understanding of the mechanisms used by the bacteria to exist in this state and to switch to metabolically active infectious form a vital problem to consider. M. tuberculosis dormancy is regula…
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Date:
November 16, 2010
Creator:
Gerasimova, Anna; Dubchak, Inna; Arkin, Adam & Gelfand, Mikhail