In silico discovery of the dormancy regulons in a number of Actinobacteria genomes

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Mycobacterium tuberculosis is a dangerous Actinobacteria infecting nearly one third of the human population. It becomes dormant and phenotypically drug resistant in response to stresses. An important feature of the M. tuberculosis pathogenesis is the prevalence of latent infection without disease, making understanding of the mechanisms used by the bacteria to exist in this state and to switch to metabolically active infectious form a vital problem to consider. M. tuberculosis dormancy is regulated by the three-component regulatory system of two kinases (DosT and DevS) and transcriprional regulator (DevR). DevR activates transcription of a set of genes, which allow the bacteria … continued below

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Gerasimova, Anna; Dubchak, Inna; Arkin, Adam & Gelfand, Mikhail November 16, 2010.

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Mycobacterium tuberculosis is a dangerous Actinobacteria infecting nearly one third of the human population. It becomes dormant and phenotypically drug resistant in response to stresses. An important feature of the M. tuberculosis pathogenesis is the prevalence of latent infection without disease, making understanding of the mechanisms used by the bacteria to exist in this state and to switch to metabolically active infectious form a vital problem to consider. M. tuberculosis dormancy is regulated by the three-component regulatory system of two kinases (DosT and DevS) and transcriprional regulator (DevR). DevR activates transcription of a set of genes, which allow the bacteria to survive long periods of anaerobiosis, and may be important for long-term survival within the host during latent infection. The DevR-regulon is studied experimentally in M. tuberculosis and few other phylogenetically close Mycobacteria spp. As many other two-component systems, the devRS operon is autoregulated. However, the mechanism of the dormancy is not completely clear even for these bacteria and there is no data describing the dormancy regulons in other species.

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  • 3rd Annual Joint Conference on Systems Biology, Regulatory Genomics and Reverse Engineering Challenges; New York City, NY; November 16 - 20, 2010

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  • Report No.: LBNL-4243E-Poster
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 1005000
  • Archival Resource Key: ark:/67531/metadc830930

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • November 16, 2010

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  • May 19, 2016, 3:16 p.m.

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  • July 18, 2019, 12:52 p.m.

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Thumbnail image of item number 1 in: 'In silico discovery of the dormancy regulons in a number of Actinobacteria genomes'.
Thumbnail image of item number 2 in: 'In silico discovery of the dormancy regulons in a number of Actinobacteria genomes'.

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Gerasimova, Anna; Dubchak, Inna; Arkin, Adam & Gelfand, Mikhail. In silico discovery of the dormancy regulons in a number of Actinobacteria genomes, poster, November 16, 2010; Berkeley, California. (https://digital.library.unt.edu/ark:/67531/metadc830930/: accessed April 1, 2023), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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