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Patent relating to silver and silver nanoparticle maldi matrix utilizing online soft landing ion mobility.
Physical Description
24 p. : ill.
Notes
Abstract: Silver nanoparticles as a sample matrix for Matrix Assisted Laser Desorption Ionization (MALDI) along with a novel method for nanoparticle development is described herein. The silver nanoparticles were generated from silver ions on the surface of a MALDI plate utilizing a Soft Landing Ion Mobility (SLIM) instrument. Upon interaction with the surface the incident silver ions were labile and aggregated into the nanoparticle structures in a time dependent fashion. Post landing analysis were completed by Time of Flight mass spectrometry (TOF), and of particular interest in the spectra were the elimination of low mass interference peaks that generally plague organic based matrices. The approach of the present invention significantly decreases sample preparation time and may lead to a preparation free MALDI source by soft landing a matrix directly on the sample surface.
Prior Publication Data: US 2012/0104243 A1, May 3, 2012.
Related U.S. Application Data: Provisional application number 61/409851, filed on November 3, 2010.
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Verbeck, Guido F. & Davila, Stephen.Silver and Silver Nanoparticle Maldi Matrix Utilizing Online Soft Landing Ion Mobility,
patent,
December 17, 2013;
[Washington, D.C.].
(https://digital.library.unt.edu/ark:/67531/metadc307065/:
accessed June 2, 2024),
University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu;
crediting UNT College of Arts and Sciences.