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open access

Functional analysis of U1-70K interacting SR proteins in pre-mRNA splicing in Arabidopsis

Description: Proteins of a serine/arginine-rich (SR) family are part of the spliceosome and are implicated in both constitutive and alternative splicing of pre-mRNAs. With the funding from DOE we have been studying alternative of splicing of genes encoding serine/arginine-rich (SR) proteins and the roles of SR proteins that interact with U1-70K in regulating basic and alternative splicing. Alternative splicing of pre-mRNAs of Arabidopsis serine/arginine-rich proteins and its regulation by hormones and stres… more
Date: November 25, 2008
Creator: Reddy, A.S.N.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

An integrative genomic and proteomic analysis of PIK3CA, PTEN and AKT mutations in breast cancer

Description: Phosphatidylinositol-3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT and PTEN mutations, and the effects of PIK3CA mutations on responsiveness to PI3K inhibition in-vitro and on outcome after adjuvant tamoxifen. PIK3CA mutations were more common in hormone receptor positive (33.8%) … more
Date: May 6, 2008
Creator: Stemke-Hale, Katherine; Gonzalez-Angulo, Ana Maria; Lluch, Ana; Neve, Richard M.; Kuo, Wen-Lin; Davies, Michael et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Breast cancer by proxy: Can the microenvironment be both the cause and consequence?

Description: Breast cancer is one of the most clear-cut examples of a solid tumor in which systemic cues play a decisive part in its development. The breast tissue is constantly subjected to changes in hormone levels and modifications in the microenvironment. This scenario is even more striking during tumor development because of the dramatic loss or aberration of basement membrane (BM) and myoepithelial cells and the gain of peritumoral myofibroblasts. We suggest that the microenvironment, defined here as … more
Date: November 16, 2008
Creator: Ronnov-Jessen, Lone & Bissell, Mina J
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices

Description: Mammary gland development, functional differentiation, and homeostasis are orchestrated and sustained by a balance of biochemical and biophysical cues from the organ's microenvironment. The three-dimensional microenvironment of the mammary gland, predominantly 'encoded' by a collaboration between the extracellular matrix (ECM), hormones, and growth factors, sends signals from ECM receptors through the cytoskeletal intracellular matrix to nuclear and chromatin structures resulting in gene expres… more
Date: December 23, 2008
Creator: Xu, Ren; Boudreau, Aaron & Bissell, Mina J
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Morphological and physiological developmental consequences of parental effects in the chicken embryo (Gallus gallus domesticus) and the zebrafish larva (Danio rerio).

Description: Cardiac, metabolic and growth response of early-stage chicken embryos to perturbations in yolk environment was investigated. Also, effects of parental hypoxia exposure on hypoxia resistance, thermal tolerance and body length of zebrafish larvae were investigated. In the first study, thyroxine, triiodothyronine and testosterone produced differential effects on heart rate and development rate of chicken embryos during the first 4 days of development. Triiodothyronine caused a dose-dependent inc… more
Date: August 2008
Creator: Ho, Dao H.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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