Breast cancer by proxy: Can the microenvironment be both the cause and consequence?

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Breast cancer is one of the most clear-cut examples of a solid tumor in which systemic cues play a decisive part in its development. The breast tissue is constantly subjected to changes in hormone levels and modifications in the microenvironment. This scenario is even more striking during tumor development because of the dramatic loss or aberration of basement membrane (BM) and myoepithelial cells and the gain of peritumoral myofibroblasts. We suggest that the microenvironment, defined here as all components of the mammary gland other than luminal and/or tumor epithelial cells, might be instrumental in maintaining organ integrity and in promoting, ... continued below

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Ronnov-Jessen, Lone & Bissell, Mina J November 16, 2008.

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Breast cancer is one of the most clear-cut examples of a solid tumor in which systemic cues play a decisive part in its development. The breast tissue is constantly subjected to changes in hormone levels and modifications in the microenvironment. This scenario is even more striking during tumor development because of the dramatic loss or aberration of basement membrane (BM) and myoepithelial cells and the gain of peritumoral myofibroblasts. We suggest that the microenvironment, defined here as all components of the mammary gland other than luminal and/or tumor epithelial cells, might be instrumental in maintaining organ integrity and in promoting, and at times even initiating, breast cancer development. As such, the tumor microenvironment and its constituents, alone or in combination, might serve as promising targets for therapy.

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  • Journal Name: Trends in Molecular Medicine; Journal Volume: 15; Journal Issue: 1; Related Information: Journal Publication Date: January 2009

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  • Report No.: LBNL-3876E
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: R01CA064786, U54CA126552
  • Office of Scientific & Technical Information Report Number: 986919
  • Archival Resource Key: ark:/67531/metadc1014872

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • November 16, 2008

Added to The UNT Digital Library

  • Oct. 14, 2017, 8:36 a.m.

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  • Oct. 17, 2017, 6:02 p.m.

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Ronnov-Jessen, Lone & Bissell, Mina J. Breast cancer by proxy: Can the microenvironment be both the cause and consequence?, article, November 16, 2008; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc1014872/: accessed November 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.