Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices

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Mammary gland development, functional differentiation, and homeostasis are orchestrated and sustained by a balance of biochemical and biophysical cues from the organ's microenvironment. The three-dimensional microenvironment of the mammary gland, predominantly 'encoded' by a collaboration between the extracellular matrix (ECM), hormones, and growth factors, sends signals from ECM receptors through the cytoskeletal intracellular matrix to nuclear and chromatin structures resulting in gene expression; the ECM in turn is regulated and remodeled by signals from the nucleus. In this chapter, we discuss how coordinated ECM deposition and remodeling is necessary for mammary gland development, how the ECM provides structural and biochemical ... continued below

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Xu, Ren; Boudreau, Aaron & Bissell, Mina J December 23, 2008.

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Mammary gland development, functional differentiation, and homeostasis are orchestrated and sustained by a balance of biochemical and biophysical cues from the organ's microenvironment. The three-dimensional microenvironment of the mammary gland, predominantly 'encoded' by a collaboration between the extracellular matrix (ECM), hormones, and growth factors, sends signals from ECM receptors through the cytoskeletal intracellular matrix to nuclear and chromatin structures resulting in gene expression; the ECM in turn is regulated and remodeled by signals from the nucleus. In this chapter, we discuss how coordinated ECM deposition and remodeling is necessary for mammary gland development, how the ECM provides structural and biochemical cues necessary for tissue-specific function, and the role of the cytoskeleton in mediating the extra - to intracellular dialogue occurring between the nucleus and the microenvironment. When operating normally, the cytoskeletal-mediated dynamic and reciprocal integration of tissue architecture and function directs mammary gland development, tissue polarity, and ultimately, tissue-specific gene expression. Cancer occurs when these dynamic interactions go awry for an extended time.

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  • Journal Name: Cancer and Metastasis Reviews; Journal Volume: 28; Journal Issue: 1-2; Related Information: Journal Publication Date: June 2009

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  • Report No.: LBNL-3881E
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: CA112970-01, R01CA057621, R01CA064786
  • Office of Scientific & Technical Information Report Number: 986916
  • Archival Resource Key: ark:/67531/metadc1012615

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • December 23, 2008

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  • Oct. 14, 2017, 8:36 a.m.

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  • Oct. 17, 2017, 7:01 p.m.

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Xu, Ren; Boudreau, Aaron & Bissell, Mina J. Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices, article, December 23, 2008; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc1012615/: accessed December 13, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.