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Effects of Gold Sodium Thiomalate on Murine Spleen Cells

Description: The effects of gold sodium thiomalate (GST) on murine spleen cells were investigated using in vitro mitogen blastogenesis techniques. Addition of GST to intact spleen cells resulted in a decreased blastogenic response to the T cell mitogen, concanavalin A (Con A). Thymidine uptake of spleen cells depleted of macrophages and cultured with Con A and GST demonstrated biphasic effects. At 2.5 pg Con A/ml, blastogenesis of macrophage depleted spleen cells was inhibited to a lesser degree than intact… more
Date: December 1986
Creator: Brownback, Paul (Paul Eldon)
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

The Adenosine Antagonist Aminophylline Attenuates Pacing-Induced Coronary Functional Hyperemia

Description: Left coronary blood flow (LCBF), left ventricular oxygen, extraction [(a-v)O₂ ], and myocardial oxygen consumption (MVO₂) were monitored in 10 dogs. HR was paced at 120 bpm and then increased to 180 bpm to elicit a hyperemic response (ΔLCBF). During the hyperemia, the vaso-dilatory response to exogenous adenosine (F_AD) was tested. Twenty min. after injection of aminophylline (100 mg/i.v.), HR was again increased. F_AD was again tested. The pacing-induced increase in MVO₂ (ΔMVO₂) was not affect… more
Date: December 1984
Creator: Randall, John Robert
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Alpha-Adrenergic Modulation of Coronary Blood Flow and Cardiac Function During Exercise in Dogs

Description: In the present study alpha-receptor modulation of coronary flow and cardiac function was examined in exercising dogs, chronically instrumented to measure: circumflex blood flow velocity (CFV), heart rate (HR), global left ventricular function (LVP and dP/dt Max) and regional left ventricular function (%SL and dL/dt (s)max). During exercise, local adrenergic blockade was produced by intracoronary injection of 1.0 mg phentolamine ( anon-specific alpha-antagonist) or .5 mp prazosin. Exercise sign… more
Date: December 1985
Creator: Overn, Steven P. (Steven Paul)
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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