Effects of Gold Sodium Thiomalate on Murine Spleen Cells

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The effects of gold sodium thiomalate (GST) on murine spleen cells were investigated using in vitro mitogen blastogenesis techniques. Addition of GST to intact spleen cells resulted in a decreased blastogenic response to the T cell mitogen, concanavalin A (Con A). Thymidine uptake of spleen cells depleted of macrophages and cultured with Con A and GST demonstrated biphasic effects. At 2.5 pg Con A/ml, blastogenesis of macrophage depleted spleen cells was inhibited to a lesser degree than intact spleen cells; whereas, at 0.5 pg Con A/ml, the macrophage depleted spleen cells were inhibited to a greater degree than the intact ... continued below

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vi, 71 leaves: ill.

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Brownback, Paul (Paul Eldon) December 1986.

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  • Brownback, Paul (Paul Eldon)

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The effects of gold sodium thiomalate (GST) on murine spleen cells were investigated using in vitro mitogen blastogenesis techniques. Addition of GST to intact spleen cells resulted in a decreased blastogenic response to the T cell mitogen, concanavalin A (Con A). Thymidine uptake of spleen cells depleted of macrophages and cultured with Con A and GST demonstrated biphasic effects. At 2.5 pg Con A/ml, blastogenesis of macrophage depleted spleen cells was inhibited to a lesser degree than intact spleen cells; whereas, at 0.5 pg Con A/ml, the macrophage depleted spleen cells were inhibited to a greater degree than the intact spleen cells. Addition of GST at intervals ranging from 0 to 48 hours indicated that inhibition occurred within 36 hours following mitogen stimulation. These results suggest that GST inhibits early events of lymphocyte activation by direct interaction with lymphocytes.

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vi, 71 leaves: ill.

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  • December 1986

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  • March 9, 2015, 8:15 a.m.

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Brownback, Paul (Paul Eldon). Effects of Gold Sodium Thiomalate on Murine Spleen Cells, thesis, December 1986; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc500436/: accessed May 21, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; .