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open access

ATCOM: Automatically Tuned Collective Communication System for SMP Clusters

Description: Conventional implementations of collective communications are based on point-to-point communications, and their optimizations have been focused on efficiency of those communication algorithms. However, point-to-point communications are not the optimal choice for modern computing clusters of SMPs due to their two-level communication structure. In recent years, a few research efforts have investigated efficient collective communications for SMP clusters. This dissertation is focused on platform-i… more
Date: December 17, 2005
Creator: Wu, Meng-Shiou
open access

Balancing a U-Shaped Assembly Line by Applying Nested Partitions Method

Description: In this study, we applied the Nested Partitions method to a U-line balancing problem and conducted experiments to evaluate the application. From the results, it is quite evident that the Nested Partitions method provided near optimal solutions (optimal in some cases). Besides, the execution time is quite short as compared to the Branch and Bound algorithm. However, for larger data sets, the algorithm took significantly longer times for execution. One of the reasons could be the way in which the… more
Date: December 17, 2005
Creator: Bhagwat, Nikhil V.
open access

Chip-Scale Bioassays Based on Surface-Enhanced Raman Scattering: Fundamentals and Applications

Description: This work explores the development and application of chip-scale bioassays based on surface-enhanced Raman scattering (SERS) for high throughput and high sensitivity analysis of biomolecules. The size effect of gold nanoparticles on the intensity of SERS is first presented. A sandwich immunoassay was performed using Raman-labeled immunogold nanoparticles with various sizes. The SERS responses were correlated to particle densities, which were obtained by atomic force microscopy (AFM). The respon… more
Date: December 17, 2005
Creator: Park, Hye-Young
open access

Cool Cluster Correctly Correlated

Description: Atomic clusters are unique objects, which occupy an intermediate position between atoms and condensed matter systems. For a long time it was thought that physical and chemical properties of atomic dusters monotonically change with increasing size of the cluster from a single atom to a condensed matter system. However, recently it has become clear that many properties of atomic clusters can change drastically with the size of the clusters. Because physical and chemical properties of clusters can… more
Date: December 17, 2005
Creator: Varganov, Sergey Aleksandrovich
open access

Exploration of Simple Analytical Approaches for Rapid Detection of Pathogenic Bacteria

Description: Many of the current methods for pathogenic bacterial detection require long sample-preparation and analysis time, as well as complex instrumentation. This dissertation explores simple analytical approaches (e.g., flow cytometry and diffuse reflectance spectroscopy) that may be applied towards ideal requirements of a microbial detection system, through method and instrumentation development, and by the creation and characterization of immunosensing platforms. This dissertation is organized into … more
Date: December 17, 2005
Creator: Rahman, Salma
open access

Giant Magnetoresistive Sensors and Magnetic Labels for Chip-Scale Detection of Immunosorbent Assays

Description: The combination of giant magnetoresistive sensors, magnetic labeling strategies, and biomolecule detection is just beginning to be explored. New readout methods and assay formats are necessary for biomolecules detection to flourish. The work presented in this dissertation describes steps toward the creation of a novel detection method for bioassays utilizing giant magnetoresistive sensors as the readout method. The introduction section contains a brief review of some of the current methods of b… more
Date: December 17, 2005
Creator: Millen, Rachel Lora
open access

Reduction of Solvent Effect in Reverse Phase Gradient Elution LC-ICP-MS

Description: Quantification in liquid chromatography (LC) is becoming very important as more researchers are using LC, not as an analytical tool itself, but as a sample introduction system for other analytical instruments. The ability of LC instrumentation to quickly separate a wide variety of compounds makes it ideal for analysis of complex mixtures. For elemental speciation, LC is joined with inductively coupled plasma mass spectrometry (ICP-MS) to separate and detect metal-containing, organic compounds i… more
Date: December 17, 2005
Creator: Sullivan, Patrick Allen
open access

Single-Molecule Imaging of DNAs with Sticky Ends at Water/Fused Silica Interface

Description: Total internal reflection fluorescence microscopy (TIRFM) was used to study intermolecular interactions of DNAs with unpaired (sticky) ends of different lengths at water/fused silica interface at the single-molecule level. Evanescent field residence time, linear velocity and adsorption/desorption frequency were measured in a microchannel for individual DNA molecules from T7, Lambda, and PSP3 phages at various pH values. The longest residence times and the highest adsorption/desorption frequenci… more
Date: December 17, 2005
Creator: Isailovic, Slavica
open access

Subunits of highly Fluorescent Protein R-Phycoerythrin as Probes for Cell Imaging and Single-Molecule Detection

Description: The purposes of our research were: (1) To characterize subunits of highly fluorescent protein R-Phycoerythrin (R-PE) and check their suitability for single-molecule detection (SMD) and cell imaging, (2) To extend the use of R-PE subunits through design of similar proteins that will be used as probes for microscopy and spectral imaging in a single cell, and (3) To demonstrate a high-throughput spectral imaging method that will rival spectral flow cytometry in the analysis of individual cells. We… more
Date: December 17, 2005
Creator: Isailovic, Dragan
open access

Synthesis and Characterization of Stimuli Responsive Block Copolymers, Self-Assembly Behavior and Applications

Description: The central theme of this thesis work is to develop new block copolymer materials for biomedical applications. While there are many reports of stimuli-responsive amphiphilic [19-21] and crosslinked hydrogel materials [22], the development of an in situ gel forming, pH responsive pentablock copolymer is a novel contribution to the field, Figure 1.1 is a sketch of an ABCBA pentablock copolymer. The A blocks are cationic tertiary amine methacrylates blocked to a central Pluronic F127 triblock copo… more
Date: December 17, 2005
Creator: Determan, Michael Duane
open access

Theoretical Studies of Pb on Si(111) and Si(100), Global Search for H-Passivated Si Nanowires, and Construction of highly Localized Quasiatomic Minimal Basis Orbitals for Mo

Description: Metal on semiconductor surfaces has been the topic of intense studies due to its technological applications. As nano-devices shrink in size, the conventional understanding of electronic devices are no longer applicable as quantum effects start to play an important role in the behavior of the devices. At the same time, when structures are approaching atomic scale, the precise fabrication by lithographic techniques, for example, are not even applicable. Very often, the fabrication of regular stru… more
Date: December 17, 2005
Creator: Chan, Tzu-Liang
open access

Tuning the Superconducting Properties of Magnesium Diboride

Description: This work is presented in the following order: A review of the relevant physics and discussion of theoretical predictions for a two gap superconducting compound is given in chapter 2. Chapter 3 provides a review of the basic properties of MgB{sub 2}. Details of sample synthesis and characterization are given in chapter 4. Chapter 5 presents normal state and superconducting properties of Mg(B{sub 1-x}C{sub x}){sub 2} wires. Attempts to increase critical current densities in filaments via titaniu… more
Date: December 17, 2005
Creator: Wilke, Rudeger Heinrich Theoderich
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