Computational modeling is of fundamental significance in mapping possible disease spread, and designing strategies for its mitigation. Conventional contact networks implement the simulation of interactions as random occurrences, presenting public health bodies with a difficult trade off between a realistic model granularity and robust design of intervention strategies. Recently, researchers have been investigating the use of agent-based models (ABMs) to embrace the complexity of real world interactions. At the same time, theoretical approaches provide epidemiologists with general optimization models in which demographics are intrinsically simplified. The emerging study of affiliation networks and co-affiliation networks provide an alternative to such trade …
continued below
The UNT Libraries serve the university and community by providing access to physical and online collections, fostering information literacy, supporting academic research, and much, much more.
Computational modeling is of fundamental significance in mapping possible disease spread, and designing strategies for its mitigation. Conventional contact networks implement the simulation of interactions as random occurrences, presenting public health bodies with a difficult trade off between a realistic model granularity and robust design of intervention strategies. Recently, researchers have been investigating the use of agent-based models (ABMs) to embrace the complexity of real world interactions. At the same time, theoretical approaches provide epidemiologists with general optimization models in which demographics are intrinsically simplified. The emerging study of affiliation networks and co-affiliation networks provide an alternative to such trade off. Co-affiliation networks maintain the realism innate to ABMs while reducing the complexity of contact networks into distinctively smaller k-partite graphs, were each partition represent a dimension of the social model. This dissertation studies the optimization of intervention strategies for infectious diseases, mainly distributed in school systems. First, concepts of synthetic populations and affiliation networks are extended to propose a modified algorithm for the synthetic reconstruction of populations. Second, the definition of multi-coaffiliation networks is presented as the main social model in which risk is quantified and evaluated, thereby obtaining vulnerability indications for each school in the system. Finally, maximization of the mitigation coverage and minimization of the overall cost of intervention strategies are proposed and compared, based on centrality measures.
This dissertation is part of the following collection of related materials.
UNT Theses and Dissertations
Theses and dissertations represent a wealth of scholarly and artistic content created by masters and doctoral students in the degree-seeking process. Some ETDs in this collection are restricted to use by the UNT community.