Attempts to develop a boronated porphyrin analog have suffered from problems associated with toxicity, solubility and, upon occasion, lability of the boron tag. One compound synthesized by one of us (SBK), designated ''SBK-II'', has evidently overcome the above problems, providing therapeutic amounts of boron in animal tumor models (20-40 ..mu..g B/g tumor) with retention times in the order of weeks. As is well known, biological efficacy will depend upon distribution within (or without) the cell. In the experiments detailed here, biological efficacy has been evaluated in Hamster V-79 cells, irradiated at the thermal neutron beam at the Brookhaven Medical Research …
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Brookhaven National Lab., Upton, NY (USA)
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Upton, New York
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Attempts to develop a boronated porphyrin analog have suffered from problems associated with toxicity, solubility and, upon occasion, lability of the boron tag. One compound synthesized by one of us (SBK), designated ''SBK-II'', has evidently overcome the above problems, providing therapeutic amounts of boron in animal tumor models (20-40 ..mu..g B/g tumor) with retention times in the order of weeks. As is well known, biological efficacy will depend upon distribution within (or without) the cell. In the experiments detailed here, biological efficacy has been evaluated in Hamster V-79 cells, irradiated at the thermal neutron beam at the Brookhaven Medical Research Reactor, using irradiation geometries and techniques as described in detail elsewhere. Cell survival curves obtained with 15 and 29 ..mu..g /sup 10/B per ml from H/sub 3//sup 10/BO/sub 3/ (''ambient'' conditions) were compared to a control (no boron) curve (data not shown). 2 refs., 3 figs., 1 tab.
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Laster, B. H.; Kahl, S. B.; Kalef-Ezra, J.; Popenoe, E. A. & Fairchild, R. G.Biological efficacy of a boronated porphyrin as measured in cell culture,
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January 1, 1987;
Upton, New York.
(https://digital.library.unt.edu/ark:/67531/metadc1189060/:
accessed May 10, 2024),
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