Comparing biological markers of Alzheimer’s disease across blood fraction and platforms: Comparing apples to oranges

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This article investigates the comparability of potential Alzheimer's disease (AD) biomarkers across blood fractions and assay platforms.

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8 p.

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O'Bryant, Sid E.; Lista, Simone; Rissman, Robert A.; Edwards, Melissa; Zhang, Fan; Hall, James R. et al. December 29, 2015.

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This article is part of the collection entitled: UNT Scholarly Works and was provided by the UNT College of Arts and Sciences to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 680 times, with 5 in the last month. More information about this article can be viewed below.

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This article investigates the comparability of potential Alzheimer's disease (AD) biomarkers across blood fractions and assay platforms.

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8 p.

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Abstract: Introduction: This study investigated the comparability of potential Alzheimer's disease (AD) biomarkers across blood fractions and assay platforms. Methods: Nonfasting serum and plasma samples from 300 participants (150 AD patients and 150 controls) were analyzed. Proteomic markers were obtained via electrochemiluminescence or Luminex technology. Comparisons were conducted via Pearson correlations. The relative importance of proteins within an AD diagnostic profile was examined using random forest importance plots. Results: On the Meso Scale Discovery multiplex platform, 10 of the 21 markers shared >50% of the variance across blood fractions (serum amyloid A R2 = 0.99, interleukin (IL)10 R2 = 0.95, fatty acid-binding protein (FABP) R2 = 0.94, I309 R2 = 0.94, IL-5 R2 = 0.94, IL-6 R2 = 0.94, eotaxin3 R2 = 0.91, IL-18 R2 = 0.87, soluble tumor necrosis factor receptor 1 R2 = 0.85, and pancreatic polypeptide R2 = 0.81). When examining protein concentrations across platforms, only five markers shared >50% of the variance (beta 2 microglobulin R2 = 0.92, IL-18 R2 = 0.80, factor VII R2 = 0.78, CRP R2 = 0.74, and FABP R2 = 0.70). Discussion: The current findings highlight the importance of considering blood fractions and assay platforms when searching for AD relevant biomarkers.

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  • Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 3, Elsevier, December 29, 2015, pp. 1-8

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  • Publication Title: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
  • Volume: 3
  • Page Start: 27
  • Page End: 34
  • Peer Reviewed: Yes

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  • December 29, 2015

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  • May 1, 2018, 12:41 a.m.

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  • Nov. 14, 2023, 2:39 p.m.

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O'Bryant, Sid E.; Lista, Simone; Rissman, Robert A.; Edwards, Melissa; Zhang, Fan; Hall, James R. et al. Comparing biological markers of Alzheimer’s disease across blood fraction and platforms: Comparing apples to oranges, article, December 29, 2015; Amsterdam, The Netherlands. (https://digital.library.unt.edu/ark:/67531/metadc1132747/: accessed July 18, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Arts and Sciences.

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