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The Influence of in Vitro Gill and Liver Metabolism of Xenobiotics on Fish Bioconcentration

Description: This dissertation examines the ability of in vitro biotransformation assays to provide an indication of metabolic potential. The potential for xenobiotic compounds to bioconcentrate in aquatic organisms is expressed through the bioconcentration factor (BCF). The metabolic loss of ibuprofen, norethindrone and propranolol was measured using rainbow trout (Oncorhynchus mykiss) and channel catfish (Ictalurus punctatus) gill and liver S9 fractions, microsomes and cell suspensions. Metabolic trans… more
Date: August 2010
Creator: Gomez, Cristi Frasier
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Initiation of the TLR4 signal transduction network : deeper understanding for better therapeutics.

Description: The innate immune system represents our first line of defense against microbial pathogens, and in many cases is activated by recognition of pathogen cellular components (dsRNA, flagella, LPS, etc.) by cell surface membrane proteins known as toll-like receptors (TLRs). As the initial trigger for innate immune response activation, TLRs also represent a means by which we can effectively control or modulate inflammatory responses. This proposal focused on TLR4, which is the cell-surface receptor pr… more
Date: September 1, 2010
Creator: Branda, Steven S. (Sandia National Laboratories, Livermore, CA); Hayden, Carl C. (Sandia National Laboratories, Livermore, CA); Sherman, Michael Y. (University of Texas Medical Branch, Galveston, TX); Sasaki, Darryl Yoshio (Sandia National Laboratories, Livermore, CA); Sale, Kenneth L. (Sandia National Laboratories, Livermore, CA) & Kent, Michael Stuart
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Multiscale analysis of nonlinear systems using computational homology

Description: This is a collaborative project between the principal investigators. However, as is to be expected, different PIs have greater focus on different aspects of the project. This report lists these major directions of research which were pursued during the funding period: (1) Computational Homology in Fluids - For the computational homology effort in thermal convection, the focus of the work during the first two years of the funding period included: (1) A clear demonstration that homology can sensi… more
Date: May 19, 2010
Creator: Mischaikow, Konstantin; Schatz, Michael; Kalies, William & Wanner, Thomas
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Multiscale analysis of nonlinear systems using computational homology

Description: This is a collaborative project between the principal investigators. However, as is to be expected, different PIs have greater focus on different aspects of the project. This report lists these major directions of research which were pursued during the funding period: (1) Computational Homology in Fluids - For the computational homology effort in thermal convection, the focus of the work during the first two years of the funding period included: (1) A clear demonstration that homology can sensi… more
Date: May 24, 2010
Creator: Mischaikow, Konstantin; Schatz, Michael; Kalies, William & Wanner, Thomas
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Final Technical Report 09 LW 112

Description: Since the development of new antibiotics is out-paced by the emergence of bacterial resistance to existing antibiotics, it is crucial to understand the genetic mechanisms underlying resistance existing antibiotics. At the center of this mystery is a poorly understood phenomenon, heteroresistance: the coexistence of multiple subpopulations with varying degrees of antibiotic resistance. A better understanding of the fundamental basis of heteroresistance could result in sorely needed breakthroughs… more
Date: November 28, 2010
Creator: Lenhoff, R J
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

APPLICATIONS OF BIOTECHNOLOGY IN DEVELOPMENT OF BIOMATERIALS: NANOTECHNOLOGY AND BIOFILMS

Description: Biotechnology is the application of biological techniques to develop new tools and products for medicine and industry. Due to various properties including chemical stability, biocompatibility, and specific activity, e.g. antimicrobial properties, many new and novel materials are being investigated for use in biosensing, drug delivery, hemodialysis, and other medical applications. Many of these materials are less than 100 nanometers in size. Nanotechnology is the engineering discipline encompass… more
Date: November 29, 2010
Creator: Brigmon, R.; Berry, T. & Narayan, R.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Characterization of the role of Fhit in maintenance of genomic integrity following low dose radiation, in vivo and in vitro

Description: The major goal of this study is to determine the effects of the Fhit pathway on low dose ({le} 0.1 Gy) ionizing radiation (IR)-induced genetic instability. Reduction of Fhit protein expression is observed in most solid tumors particularly in those tumors resulting from exposure to environmental carcinogens. Therefore, characterization of the role of the Fhit-dependent pathway in preventing low dose IR-induced genetic instability will provide useful parameters for evaluating the low dose IR-indu… more
Date: May 31, 2010
Creator: Wang, Ya
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department

Two Component Signal Transduction in Desulfovibrio Species

Description: The environmentally relevant Desulfovibrio species are sulfate-reducing bacteria that are of interest in the bioremediation of heavy metal contaminated water. Among these, the genome of D. vulgaris Hildenborough encodes a large number of two component systems consisting of 72 putative response regulators (RR) and 64 putative histidinekinases (HK), the majority of which are uncharacterized. We classified the D. vulgaris Hildenborough RRs based on their output domains and compared the distributio… more
Date: May 17, 2010
Creator: Luning, Eric; Rajeev, Lara; Ray, Jayashree & Mukhopadhyay, Aindrila
Item Type: Refine your search to only Poster
Partner: UNT Libraries Government Documents Department
open access

The Expression Level of HJURP has an Independent Prognostic Impact and Predicts the Sensitivity to Radiotherapy in Breast Cancer

Description: Introduction: HJURP (Holliday Junction Recognition Protein) is a newly discovered gene reported to function at centromeres and to interact with CENPA. However its role in tumor development remains largely unknown. The goal of this study was to investigate the clinical significance of HJURP in breast cancer and its correlation with radiotherapeutic outcome. Methods: We measured HJURP expression level in human breast cancer cell lines and primary breast cancers by Western blot and/or by Affymetri… more
Date: June 25, 2010
Creator: Hu, Zhi; Huang, Ge; Sadanandam, Anguraj; Gu, Shenda; Lenburg, Marc E.; Pai, Melody et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Persistence of gamma-H2AX and 53BP1 foci in proliferating and nonproliferating human mammary epithelial cells after exposure to gamma-rays or iron ions

Description: To investigate {gamma}-H2AX (phosphorylated histone H2AX) and 53BP1 (tumour protein 53 binding protein No. 1) foci formation and removal in proliferating and non-proliferating human mammary epithelial cells (HMEC) after exposure to sparsely and densely ionizing radiation under different cell culture conditions. HMEC cells were grown either as monolayers (2D) or in extracellular matrix to allow the formation of acinar structures in vitro (3D). Foci numbers were quantified by image analysis at va… more
Date: December 22, 2010
Creator: Groesser, Torsten; Chang, Hang; Fontenay, Gerald; Chen, James; Costes, Sylvain V.; Barcellos-Hoff, Mary Helen et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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