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The protein conformational basis of isoflavone biosynthesis

Description: Authors of the article assert that isoflavonoids play important roles in plant defense and also exhibit a range of mammalian health-promoting activities. They emphasize that understanding the structural basis of isoflavone biosynthesis will facilitate the engineering of new bioactive isoflavonoids.
Date: November 15, 2022
Creator: Wang, Xiaoqiang; Pan, Haiyun; Sagurthi, Someswar; Paris, Vincent; Zhuo, Chunliu & Dixon, R. A.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Stereochemical and Biosynthetic Rationalisation of the Tropolone Sesquiterpenoids

Description: Article summarises the known structures, biological activities, and biosynthetic pathways of the tropolone sesquiterpenoid family of fungal secondary metabolites. Synthesis of this knowledge allows likely structural and stereochemical misassignments to be revised and shows how the compounds can be divided into three main biosynthetic classes based on the stereochemistry of key biosynthetic steps.
Date: August 31, 2022
Creator: Li, Lei & Cox, Russell, J.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Proteomic and metabolic disturbances in lignin-modified Brachypodium distachyon

Description: This article investigates global metabolic responses to lignin pathway perturbations in the model grass Brachypodium distachyon using a systems biology approach.
Date: June 7, 2022
Creator: Barros, Jaime; Shrestha, Him K.; Serrani-Yarce, Juan C.; Engle, Nancy L.; Abraham, Paul E.; Tschaplinski, Timothy J. et al.
Item Type: Refine your search to only Article
Partner: University of North Texas
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Subcellular localization of fungal specialized metabolites

Description: Article discusses how fungal specialized metabolites play an important role in the environment and have impacted human health and survival significantly. This review illustrates the biosynthesis of specialized metabolites where the localization of all, or some, of the biosynthetic enzymes have been determined and describes the methods used to identify the sub-cellular localization.
Date: May 25, 2022
Creator: Skellam, Elizabeth
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Developmental changes in lignin composition are driven by both monolignol supply and laccase specificity

Description: Article proposes a model in which, during C-lignin biosynthesis, caffeyl alcohol noncompetitively inhibits oxidation of coniferyl alcohol by cell wall laccases, a process that might limit movement of coniferyl alcohol to the apoplast.
Date: March 9, 2022
Creator: Zhou, Chunliu; Wang, Xin; Docampo-Palacios, Maite; Sanders, Brian C.; Engle, Nancy L.; Tschaplinski, Timothy J. et al.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Better together: Protein partnerships for lineage-specific oil accumulation

Description: Article reviews recent evidence that protein–protein interactions in each of the three major phases of oil formation appear to have profound effects on specialized oil accumulation. This article is part of the special issue: Physiology and metabolism (2022).
Date: February 24, 2022
Creator: Busta, Lucas; Chapman, Kent Dean & Cahoon, Edgar B.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Phylogenetic Occurrence of the Phenylpropanoid Pathway and Lignin Biosynthesis in Plants

Description: This article is a review summarizing recent progress in defining the lignin biosynthetic pathway in lycophytes, monilophytes, gymnosperms, and angiosperms. This review provides new insights into the genetic engineering of the lignin biosynthetic pathway to overcome biomass recalcitrance in bioenergy crops.
Date: August 17, 2021
Creator: Yao, Tao; Feng, Kai; Xie, Meng; Barros, Jaime; Tschaplinski, Timothy J.; Tuskan, Gerald et al.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Dual activity of anthocyanidin reductase supports the dominant plant proanthocyanidin extension unit pathway

Description: This article presents research on genetic and biochemical analyses that shows ANR has dual activity and is involved not only in the production of (−)-epicatechin starter units but also in the formation of 2,3-cis-leucocyanidin to serve as (−)-epicatechin extension units. The results find that differences in the product specificities of ANRs account for the presence/absence of PA polymerization and the compositions of PAs across plant species
Date: May 14, 2021
Creator: Jun, Ji Hyung; Lu, Nan; Docampo-Palacios, Maite; Wang, Xiaoqiang & Dixon, R. A.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Targeting hydroxycinnamoyl CoA: shikimate hydroxycinnamoyl transferase for lignin modification in Brachypodium distachyon

Description: This article conducts a study to evaluate the utility of Hydroxycinnamoyl CoA: shikimate hydroxycinnamoyl transferase (HCT) as a target for lignin modification in a species with an “incomplete” shikimate shunt. Results imply that this gene is a preferred target for biotechnological improvement of grasses for bioprocessing.
Date: February 27, 2021
Creator: Serrani-Yarce, Juan Carlos; Escamilla-Treviño, Luis; Barros, Jaime; Gallego-Giraldo, Lina; Pu, Yunqiao; Ragauskas, Arthur J. (Arthur Jonas), 1957- et al.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans

Description: This article investigates the role of the highly conserved α,β-hydrolase enzymes PyiE and ORFZ during the biosynthesis of pyrichalasin H and the ACE1 metabolite, respectively, using gene knockout and complementation techniques. Taken together the results suggest that the α,β-hydrolase enzymes are essential for first ring cyclisation, but the precise nature of the intermediates remains to be determined.
Date: November 4, 2020
Creator: Zhang, Haili; Hantke, Verena; Bruhnke, Pia; Skellam, Elizabeth & Cox, Russell J.
Item Type: Refine your search to only Article
Partner: UNT College of Science
open access

Substrate Specificity of LACCASE8 Facilitates Polymerization of Caffeyl Alcohol for C-Lignin Biosynthesis in the Seed Coat of Cleome hassleriana

Description: This article finds that the transcript profile of the laccase gene ChLAC8 parallels the accumulation of C-lignin during seed coat development. Recombinant ChLAC8 oxidizes caffeyl and sinapyl alcohols, generating their corresponding dimers or trimers in vitro, but cannot oxidize coniferyl alcohol. The authors propose a basis for this substrate preference based on molecular modeling/docking experiments. Suppression of ChLAC8 expression led to significantly reduced C-lignin content in the seed coa… more
Date: October 9, 2020
Creator: Wang, Xin; Zhuo, Chunliu; Xiao, Xirong; Wang, Xiaoqiang; Docampo-Palacios, Maite; Chen, Fang et al.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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LBD29-Involved Auxin Signaling Represses NAC Master Regulators and Fiber Wall Biosynthesis

Description: This article uses a large-scale mutant screening to identify a dominant activation-tagging mutant, fiberless-d (fls-d), showing defective SCW development in stem fibers, similar to that of the nac secondary wall thickening promoting factor1-1 (nst1-1)nst3-3 double mutant. The results demonstrate auxin is upstream of LBD29 in repressing NAC master regulators, and therefore sheds new light on the regulation of SCW biosynthesis in Arabidopsis.
Date: August 3, 2019
Creator: Lee, Kwang-Hee; Du, Qian; Zhuo, Chunliu; Qi, Liying & Wang, Huanzhong
Item Type: Refine your search to only Article
Partner: UNT College of Science
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VvLAR1 and VvLAR2 Are Bifunctional Enzymes for Proanthocyanidin Biosynthesis in Grapevine

Description: This article shows that both Cys-EC and 4β-(S-cysteinyl)-catechin (Cys-C) are present in grapevine. The data from this study advance knowledge of PA building blocks and LAR function and provide targets for grapevine breeding to alter PA composition.
Date: May 15, 2019
Creator: Dixon, R. A.; Jun, Ji Hyung; Yu, Keji & Duan, Changqing
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Genetic Mutations in the S-loop of Human Glutathione Synthetase: Links Between Substrate Binding, Active Site Structure and Allostery

Description: This article uses molecular dynamics simulations and experimental point mutations to probe the role of S-loop residues in tertiary structure, substrate binding, and allosteric communication.
Date: November 29, 2018
Creator: Ingle, Brandall L.; Shrestha, Bibesh; De Jesus, Margarita C.; Conrad-Webb, Heather M.; Anderson, Mary E. & Cundari, Thomas R., 1964-
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Gene regulatory networks for lignin biosynthesis in switchgrass (Panicum virgatum)

Description: This article presents a combination of computational and experimental approaches to develop gene regulatory networks for lignin formation in switchgrass (Panicum virgatum), which has been selected as a biofuel crop in the United States.
Date: August 24, 2018
Creator: Rao, Xiaolan; Chen, Xin; Shen, Hui; Ma, Qin; Li, Guifen; Tang, Yuhong et al.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Glucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans

Description: This article discusses how RNA-sequencing analysis was performed to assess how a glucose-supplemented diet and/or a hyl-2 mutation altered the transcriptome.
Date: August 5, 2016
Creator: Ladage, Mary L.; King, Skylar D.; Burks, David J.; Quan, Daniel L.; Garcia, Anastacia M.; Azad, Rajeev K. et al.
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences
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Glucose and Altered Ceramide Biosynthesis Impact the Transcriptome and the Lipidome of Caenorhabditis elegans

Description: The worldwide rise of diabetes and obesity has spurred research investigating the molecular mechanisms that mediate the deleterious effects associated with these diseases. Individuals with diabetes and/or obesity are at increased risk from a variety of health consequences, including heart attack, stroke and peripheral vascular disease; all of these complications have oxygen deprivation as the central component of their pathology. The nematode Caenorhabditis elegans has been established as a mod… more
Date: August 2016
Creator: Ladage, Mary Lee
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Computational inference of the structure and regulation of the lignin pathway in Panicum virgatum

Description: This article uses a systems biological modeling approach to address the challenge of in vivo measurements to elucidate the structure and regulation of the lignin pathway through a computational characterization of alternate candidate topologies.
Date: September 17, 2015
Creator: Faraji, Mojdeh; Fonseca, Luis L.; Escamilla-Treviño, Luis; Dixon, R. A. & Voit, Eberhard O.
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences
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Engineering Ralstonia eutropha for Production of Isobutanol (IBT) Motor Fuel from Carbon Dioxide, Hydrogen, and Oxygen Project Final Report

Description: This research project is a collaboration between the Sinskey laboratory at MIT and the Worden laboratory at Michigan State University. The goal of the project is to produce Isobutanol (IBT), a branched-chain alcohol that can serve as a drop-in transportation fuel, through the engineered microbial biosynthesis of Carbon Dioxide, Hydrogen, and Oxygen using a novel bioreactor. This final technical report presents the findings of both the biological engineering work at MIT that extended the native … more
Date: December 16, 2013
Creator: Sinskey, Anthony J.; Worden, Robert Mark; Brigham, Christopher; Lu, Jingnan; Quimby, John Westlake; Gai, Claudia et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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