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Early lung cancer detection in uranium miners with abnormal sputum cytology. Technical progress report, July 31, 1991--July 31, 1992

Description: This work supported by the United States of Energy, continues to add data on the health affects of cigarette smoking and radon exposure on uranium miners. Since the last Technical Progress Report in July or 1991, 537 sputum cytology samples have been collected on the 300 uranium workers in the surveillance study. To date there are 436 lung cancer cases in the Uranium Miner Tumor Registry with diagnostic slides from surgery and/or autopsy; an additional 40 cases have been diagnosed with sputum c… more
Date: August 1, 1992
Creator: Saccomanno, G.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Cellular morphometry of the bronchi of human and dog lungs

Description: Quantitative data of the human bronchial epithelial cells at possible risk for malignant transformation in lung cancer is crucial for accurate radon dosimetry and risk analysis. The locations and other parameters of the nuclei which may be damaged by [alpha] particles must be determined and compared in different airway generations, among smokers, non-smokers and ex-smokers, between men and women and in people of different ages. This proposal includes extended morphometric studies on electron mi… more
Date: September 1, 1992
Creator: Robbins, E.S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Cellular morphometry of the bronchi of human and dog lungs. Annual progress report, April 1, 1992--March 31, 1993

Description: Quantitative data of the human bronchial epithelial cells at possible risk for malignant transformation in lung cancer is crucial for accurate radon dosimetry and risk analysis. The locations and other parameters of the nuclei which may be damaged by {alpha} particles must be determined and compared in different airway generations, among smokers, non-smokers and ex-smokers, between men and women and in people of different ages. This proposal includes extended morphometric studies on electron mi… more
Date: September 1, 1992
Creator: Robbins, E. S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

INEL BNCT Research Program, May/June 1992

Description: This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophenylaianine (IBPA) are descr… more
Date: September 1, 1992
Creator: Venhuizen, J.R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Quantifying lifetime exposure to ultraviolet radiation in the epidemiology of cutaneous malignant melanoma: A pilot study

Description: This pilot study uses a unique method to calculate cumulative lifetime exposure to, ultraviolet radiation-b to determine if this refined method would indicate differences in lifetime cumulative UVB exposure between age and sex matched controls. Forty-four age and sex matched cases and controls demonstrated no significant difference in mean cumulative lifetime UVB exposure based on the duration and location of residence. This pilot study suggests that further analysis of the dataset should be co… more
Date: October 1, 1992
Creator: Lea, C.S.; Selvin, S. (California Univ., Berkeley, CA (United States). Dept. of Biomedical and Environmental Health Sciences Lawrence Berkeley Lab., CA (United States)); Buffler, P.A. (California Univ., Berkeley, CA (United States). Dept. of Biomedical and Environmental Health Sciences); Scotto, J. (National Cancer Inst., Bethesda, MD (United States). Biostatistics Branch) & Berwick, M. (Cancer Pre
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The role of aging and DNA repair in chronic disease. Final progress report, December 1, 1985--September 29, 1993

Description: We carried out a molecular epidemiological study of the DNA repair of photochemical damage as a risk factor in basal cell carcinoma (BCC). In that clinic-based control study of 88 cases and 135 cancer-free control it was found that DNA repair in the controls declined linearly at a rate of 0.61% per year over a 30-60 year age group. However, repair in younger BCC cases, significantly less than their age-matched controls, did not decline at the same rate so that the repair differences between the… more
Date: November 1, 1993
Creator: Grossman, L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

A Novel Function for the nm23-Hl Gene: Overexpression in Human Breast Carcinoma Cells Leads to the Formation of Basement Membrane and Growth Arrest

Description: We have developed a culture system using reconstituted basement membrane components in which normal human mammary epithelial cells exhibit several aspects of the development and differentiation process, including formation of acinar-like structures, production and basal deposition of basement membrane components, and production and apical secretion of sialomucins. Cell lines and cultures from human breast carcinomas failed to recapitulate this process. The data indicate the importance of cellul… more
Date: January 1, 1994
Creator: Howlett, Anthony R; Petersen, Ole W; Steeg, Patricia S & Bissell, Mina J
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Noninvasive identification of bladder cancer with sub-surface backscattered light

Description: A non-invasive diagnostic tool that could identify malignancy in situ and in real time would have a major impact on the detection and treatment of cancer. We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. Absorp… more
Date: February 1, 1994
Creator: Bigio, I. J.; Mourant, J. R.; Boyer, J.; Johnson, T.; Shimada, T. & Conn, R. L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Dose-response relationships for female radium dial workers: A new look

Description: The values of initial systemic intake and of skeletal dose for all of the U.S. radium cases have recently been revised. This revision was required following the demonstrations by Rundo and by Keane that humans who were exposed to radium as adults lost radium at a rate that depended on the quantity of radium originally deposited within their bodies. These new values have been used to define new dose-response relationships for both the bone sarcomas and the carcinomas arising in the paranasal sin… more
Date: May 1, 1994
Creator: Rowland, R. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Tumorigenesis in the U.S. radium luminizers: How unsafe was this occupation?

Description: Dose-response data are presented from the U.S. female workers who were exposed to radium through the painting of luminous dials and who subsequently had their skeletal burdens measured by whole-body counting and radon breath analyses. Lognormal data analyses were done for radium-induced bone sarcomas and head carcinomas after the populations of the respective doses were first determined to be lognormally distributed. The calculated geometric mean and standard deviation for each dose population … more
Date: May 1, 1994
Creator: Thomas, R. G.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Characterization and utilization of a monoclonal antibody against pancreatic carcinoma

Description: A monoclonal antibody was produced against a human pancreatic adenocarcinoma line and was found to react with several different human carcinomas by immunoperoxidase staining of fixed tissues. The original cells used to generate the monoclonal antibody were treated with detergent to lyse the cell membrane. A membrane associated protein of molecular weight 35kD was isolated from this detergent lysed preparation and found to be recognized by the monoclonal antibody. The binding constant of the ant… more
Date: October 1, 1994
Creator: Kurtzman, S. H.; Sindelar, W. F.; Atcher, R. W.; Mitchell, J. B.; DeGraff, W. G.; Gamson, J. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Cellular growth and survival are mediated by beta 1 integrins in normal human breast epithelium but not in breast carcinoma

Description: We previously established a rapid three-dimensional assay for discrimination of normal and malignant human breast epithelial cells using a laminin-rich reconstituted basement membrane. In this assay, normal epithelial cells differentiate into well-organized acinar structures whereas tumor cells fail to recapitulate this process and produce large, disordered colonies. The data suggest that breast acinar morphogenesis and differentiation is regulated by cell-extracellular matrix (ECM) interaction… more
Date: November 28, 1994
Creator: Howlett, Anthony R; Bailey, Nina; Damsky, Caroline; Petersen, Ole W & Bissell, Mina J
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Cellular morphometry and cycling cell populations of human and dog bronchi. Annual progress report, April 1, 1994--March 31, 1995

Description: Quantitative data of the human bronchial epithelial cells at possible risk for malignant transformation in lung cancer is crucial for accurate radon dosimetry and risk analysis. The nuclei of these cells may be targets for damage by {alpha} particles. Then it is important to determine the locations and other parameters of these nuclei in different airway generations, among smokers, non-smokers and ex-smokers, between men and women and in people of different ages. This proposal includes extended… more
Date: December 1, 1994
Creator: Robbins, E. S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Interim report on intrathoracic radiotherapy of human small-cell lung carcinoma in nude mice with Re-188-RC-160, a radiolabeled somatostatin analogue

Description: The purpose of this study was to evaluate the therapeutic efficacy of Re-188-RC-160 in experimental models of human small cell lung carcinomas which mimic the clinical presentation. In the experimental model, cells from the human small cell lung carcinoma cell line NCI-H69 cells were inoculated into the thoracic cavity of athymic mice and rats. Subsequently, the biodistribution of Re-188-RC-160 after injection into the pleural cavity, a radiolabeled somatostatin analogue, was monitored as was t… more
Date: July 1, 1995
Creator: Zamora, P. O.; Bender, H.; Biersack, H. J. & Knapp, F. F. Jr.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Investigation of excess thyroid cancer incidence in Los Alamos County

Description: Los Alamos County (LAC) is home to the Los Alamos National Laboratory, a U.S. Department of Energy (DOE) nuclear research and design facility. In 1991, the DOE funded the New Mexico Department of Health to conduct a review of cancer incidence rates in LAC in response to citizen concerns over what was perceived as a large excess of brain tumors and a possible relationship to radiological contaminants from the Laboratory. The study found no unusual or alarming pattern in the incidence of brain ca… more
Date: April 1, 1996
Creator: Athas, W.F.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Multigene deletions in lung adenocarcinomas from irradiated and control mice

Description: K-ras codon 12 point mutations mRb and p53 gene deletions were examined in tissues from 120 normal lungs and lung adenocarcinomas that were Formalin-treated and paraffin-embedded 25 years ago. The results showed that 12 of 60 (20%) lung adenocarcinomas had mRb deletions. All lung adenocarcinomas that were initially found bearing deleted mRb had p53 deletions (15 of 15; 100%). A significantly higher mutation frequency for K-ras codon 12 point mutations was also found in the lung adenocarcinomas … more
Date: June 1, 1996
Creator: Zhang, Yueru & Woloschak, Gayle E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Technology Development, Evaluation, and Application (TDEA) FY 1995 progress report - Environmental, Safety, and Health (ESH) division

Description: This report covers six months of effort, including startup time. Five projects were supported by the division: Pilot Program for the Risk-Based Surveillance of Lung Cancer in Los Alamos National Laboratory Workers, Optimization of Placement of Workplace Continuous Air Monitoring Instrumentation, A Polymeric Barrier Monitor to Protect Workers, Evaluation of a Real-Time Beryllium Detection Instrument and the Implications of Its Use, and High-Energy Dosimetry. A project summary for each is provide… more
Date: September 1, 1996
Creator: Andrews, L. Larry
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Single fiber beta detector for stereotactic biopsy and intraoperative lumpectomy of breast cancer

Description: We have developed an intraoperative probe for use in early detection of breast cancer and aiding lumpectomy. The probe consists of a small plastic scintillator, 0.8mm dia and 3mm long, coupled to a single clear optical-fiber strand, and solid state photomultiplier. Due to the small size of the probe, it can be placed inside of a small gauge biopsy needle. The scintillator is very efficient in detecting betas and positrons while being very in efficient to energetic gammas due to small size and l… more
Date: October 1, 1996
Creator: Atac, M.; Nalcioglu, O. & Roeck, W.W.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Misregulation of Stromelysin-1 in Mouse Mammary Tumor Cells Accompanies Acquisition of Stromelysin-1 dependent Invasive Properties

Description: Stromelysin-1 is a member of the metalloproteinase family of extracellular matrix-degrading enzymes that regulates tissue remodeling. We previously established a transgenic mouse model in which rat stromelysin-1 targeted to the mammary gland augmented expression of endogenous stromelysin-1, disrupted functional differentiation, and induced mammary tumors. A cell line generated from an adenocarcinoma in one of these animals and a previously described mammary tumor cell line generated in culture … more
Date: February 21, 1997
Creator: Lochter, A.; Srebrow, A.; Sympson, C.J.; Terracio, N.; Werb, Z. & Bissell, M.J.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Development of a kinetic model and calculation of radiation dose estimates for sodium iodide-{sup 131}I in athyroid individuals

Description: The treatment for some thyroid carcinomas involves surgically removing the thyroid gland and administering the radiopharmaceutical Sodium iodide-{sup 131}I (NaI). A diagnostic dose of NaI is given to the patient to determine if remnant tissue from the gland remains or larger doses are administered in order to treat the malignant tissue. Past research regarding NaI uptake and retention in euthyroid individuals (normal functioning thyroid) reveal that radioiodine concentrates mainly in the thyroi… more
Date: July 1, 1997
Creator: Rodriguez, M.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Rb and p53 gene deletions in lung adenocarcinomas from irradiated and control mice

Description: This study was conducted on mouse lung adenocarcinoma tissues that were formalin-treated and paraffin-embedded 25 years ago to investigate the large gene deletions of mRb and p53 in B6CF{sub 1} male mice. A total of 80 lung tissue samples from irradiated mice and 40 lung samples from nonirradiated controls were randomly selected and examined in the mRb portion of this study. The results showed a significant (P < 0.05) higher percentage of mRb deletions in lung adenocarcinomas from mice exposed … more
Date: August 1, 1997
Creator: Zhang, Yueru & Woloschak, Gayle E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Clostridium Spore Attachment to Human Cells

Description: This paper uses high resolution scanning electron microscopy (SEM) with a LaB6 gun and the newest commercial field emission guns, to obtain high magnification images of intact clostridial spores throughout the activation/germination/outgrowth process. By high resolution SEM, the clostridial exosporial membrane can be seen to produce numerous delicate projections (following activation), that extend from the exosporial surface to a nutritive substrate (agar), or cell surface when anaerobically in… more
Date: August 10, 1997
Creator: Panessa-Warren, B.; Tortora, G. & Warren, J.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Expression of Autoactivated Stromelysin-1 in Mammary Glands of Transgenic Mice Leads to a Reactive Stroma During Early Development

Description: Extracellular matrix and extracellular matrix-degrading matrix metalloproteinases play a key role in interactions between the epithelium and the mesenchyme during mammary gland development and disease. In patients with breast cancer, the mammary mesenchyme undergoes a stromal reaction, the etiology of which is unknown. We previously showed that targeting of an autoactivating mutant of the matrix metalloproteinase stromelysin-1 to mammary epithelia of transgenic mice resulted in reduced mammary … more
Date: April 24, 1998
Creator: Thomasset, N.; Lochter, A.; Sympson, C.J.; Lund, L.R.; Williams, D.R.; Behrendtsen, O. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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