Interim report on intrathoracic radiotherapy of human small-cell lung carcinoma in nude mice with Re-188-RC-160, a radiolabeled somatostatin analogue

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Description

The purpose of this study was to evaluate the therapeutic efficacy of Re-188-RC-160 in experimental models of human small cell lung carcinomas which mimic the clinical presentation. In the experimental model, cells from the human small cell lung carcinoma cell line NCI-H69 cells were inoculated into the thoracic cavity of athymic mice and rats. Subsequently, the biodistribution of Re-188-RC-160 after injection into the pleural cavity, a radiolabeled somatostatin analogue, was monitored as was the effect on the subsequent growth of tumors. The results presented here, and which are a part of a larger series of studies, suggest that Re-188-RC-160 can ... continued below

Physical Description

17 p.

Creation Information

Zamora, P.O.; Bender, H.; Biersack, H.J. & Knapp, F.F. Jr. July 1, 1995.

Context

This report is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. More information about this report can be viewed below.

Authors

Zamora, P.O. Univ. of Bonn (Germany). Dept. of Nuclear Medicine
Bender, H.
Biersack, H.J. Univ. of Bonn (Germany). Dept. of Nuclear Medicine
Knapp, F.F. Jr. Oak Ridge National Lab., TN (United States). Health Sciences Research Div.

United States. Department of Energy. USDOE, Washington, DC (United States)

Publisher

Oak Ridge National Laboratory
Publisher Info: Oak Ridge National Lab., TN (United States)

Place of Publication: Tennessee

Provided By

UNT Libraries Government Documents Department

Serving as both a federal and a state depository library, the UNT Libraries Government Documents Department maintains millions of items in a variety of formats. The department is a member of the FDLP Content Partnerships Program and an Affiliated Archive of the National Archives.

Description

The purpose of this study was to evaluate the therapeutic efficacy of Re-188-RC-160 in experimental models of human small cell lung carcinomas which mimic the clinical presentation. In the experimental model, cells from the human small cell lung carcinoma cell line NCI-H69 cells were inoculated into the thoracic cavity of athymic mice and rats. Subsequently, the biodistribution of Re-188-RC-160 after injection into the pleural cavity, a radiolabeled somatostatin analogue, was monitored as was the effect on the subsequent growth of tumors. The results presented here, and which are a part of a larger series of studies, suggest that Re-188-RC-160 can be effectively used in this animal model to restrict the growth of small cell lung carcinoma in the thoracic cavity.

Physical Description

17 p.

Notes

INIS; OSTI as DE95014289

Subjects

Keywords

STI Subject Categories

55 Biology And Medicine, Basic Studies

Source

5. Mediterranean symposium on nuclear medicine and radiopharmaceuticals - receptors, Athens (Greece), 23-28 May 1995

Language

English

Item Type

Report

Identifier

Unique identifying numbers for this report in the Digital Library or other systems.

Other: DE95014289
Report No.: CONF-9505232--2
Grant Number: AC05-84OR21400
DOI: 10.2172/87003 | External Link
Office of Scientific & Technical Information Report Number: 87003
Archival Resource Key: ark:/67531/metadc792806

Collections

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

July 1, 1995

Added to The UNT Digital Library

Dec. 19, 2015, 7:14 p.m.

Description Last Updated

Jan. 25, 2016, 2:15 p.m.

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Zamora, P.O.; Bender, H.; Biersack, H.J. & Knapp, F.F. Jr. Interim report on intrathoracic radiotherapy of human small-cell lung carcinoma in nude mice with Re-188-RC-160, a radiolabeled somatostatin analogue, report, July 1, 1995; Tennessee. (digital.library.unt.edu/ark:/67531/metadc792806/: accessed April 26, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.