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captions transcript

[News Clip: Ferguson Atlanta]

Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.
Date: January 28, 1994, 10:00 p.m.
Duration: 1 minute 37 seconds
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Item Type: Refine your search to only Video
Partner: UNT Libraries Special Collections
open access

Cancer risks and neutron RBE's from Hiroshima and Nagasaki

Description: The new radiation dose estimates for Hiroshima and Nagasaki are here combined with epidemiologic data from the A-bomb survivors and examined radiobiologically for compatability with other human and experimental data. The new doses show certain improvements over the original T65 doses. However, they suggest for chronic granulocytic leukemia, total malignancies, and chromosome aberrations, at neutron doses of 1 rad, RBEs in excess of 100, higher than expected from other findings. This and other i… more
Date: April 30, 1982
Creator: Dobson, R.L. & Straume, T.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Studies in Development Immunogenetics. Annual Progress Report

Description: This contract provides the research support for a group concerned with a relatively large range of problems. The integrating thread that runs through it is that of an interest in development and its genetic regulation, mainly in complex organisms and with an emphasis on the immune system as a model for developmental analysis and as a tool for following the development of other systems, especially the brain. It includes studies of biochemical genetics, primarily from a developmental viewpoint an… more
Date: March 26, 1975
Creator: Owen, R. D.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Improved radioimmunotherapy of hematologic malignancies

Description: This research project proposes to develop novel new approaches of improving the radioimmunodetection and radioimmunotherapy of malignancies by augmenting retention of radioimmunoconjugates by tumor cells. The approaches shown to be effective in these laboratory experiments will subsequently be incorporated into out ongoing clinical trials in patients. Specific project objectives include: to study the rates of endocytosis, intracellular routing, and metabolic degradation of radiolabeled monoclon… more
Date: March 24, 1992
Creator: Press, O.W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
captions transcript

[News Clip: Atlanta]

Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.
Date: January 30, 1994
Duration: 1 minute 57 seconds
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Item Type: Refine your search to only Video
Partner: UNT Libraries Special Collections
open access

A-bomb survivor dosimetry update

Description: A-bomb survivor data have been generally accepted as applicable. Also, the initial radiations have tended to be accepted as the dominant radiation source for all survivors. There was general acceptance of the essential reliability of both the biological effects data and the causative radiation dose values. There are considerations casting doubt on these acceptances, but very little quantification of th implied uncertainties has been attempted. The exception was A-bomb survivor dosimetry, where … more
Date: June 1, 1982
Creator: Loewe, W.E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

The role of intestinal injury in hematopoietic gamma ray mortality

Description: Leukemia patients typically have low granulocyte counts as do those with aplastic anemia. A review of the literature on these latter patients quickly indicates that they live much longer than leukemic patients with the same counts. To check this numerically, the survival times for 12 aplastic anemia patients reported in 1934 were compared with the expected survival times for more recent patients using methods employed to compute the probabilities. On the average, the aplastic anemia patients li… more
Date: December 1, 1987
Creator: Broyles, A. A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Estimates of radiation doses in tissue and organs and risk of excess cancer in the single-course radiotherapy patients treated for ankylosing spondylitis in England and Wales

Description: The estimates of absorbed doses of x rays and excess risk of cancer in bone marrow and heavily irradiated sites are extremely crude and are based on very limited data and on a number of assumptions. Some of these assumptions may later prove to be incorrect, but it is probable that they are correct to within a factor of 2. The excess cancer risk estimates calculated compare well with the most reliable epidemiological surveys thus far studied. This is particularly important for cancers of heavily… more
Date: February 1, 1982
Creator: Fabrikant, J.I. & Lyman, J.T.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Division of Biological and Medical Research annual report 1978

Description: The research during 1978 in the Division of Biological and Medical Research, Argonne National Laboratory, is summarized. Studies related to nuclear energy include responses of beagles to continuous low-level /sup 60/Co gamma radiation, and development of leukemic indicators; comparison of lifetime effects in mice of low-level neutron and /sup 60/Co gamma radiation; genetic effects of high LET radiations; and metabolic and therapeutic studies of heavy metals. Studies of nonnuclear energy sources… more
Date: January 1, 1978
Creator: Rosenthal, M.W. (ed.)
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The carcinogenic risks of low-LET and high-LET ionizing radiations

Description: This report presents a discussion on risk from ionizing radiations to human populations. Important new information on human beings has come mainly from further follow-up of existing epidemiological studies, notably the Japanese atomic bomb survivors and the ankylosing spondylitis patients; from new epidemiological surveys, such as the patients treated for cancer of the uterine cervix; and from combined surveys, including workers exposed in underground mines. Since the numerous and complex diffe… more
Date: August 1, 1991
Creator: Fabrikant, J.I. (Lawrence Berkeley Lab., CA (United States) California Univ., San Francisco, CA (United States))
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Non-destructive Identification of Individual Leukemia Cells by Optical Trapping Raman Spectroscopy

Description: Currently, a combination of technologies is typically required to assess the malignancy of cancer cells. These methods often lack the specificity and sensitivity necessary for early, accurate diagnosis. Here we demonstrate using clinical samples the application of laser trapping Raman spectroscopy as a novel approach that provides intrinsic biochemical markers for the noninvasive detection of individual cancer cells. The Raman spectra of live, hematopoietic cells provide reliable molecular fing… more
Date: March 5, 2007
Creator: Chan, J W; Taylor, D S; Lane, S; Zwerdling, T; Tuscano, J & Huser, T
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Hematopoietic cell crisis: An early stage of evolving myeloid leukemia following radiation exposure

Description: Under select radiological conditions, chronic radiation exposure elicits a high incidence of myeloproliferative disease, principally myeloid leukemia (ML), in beagles. Previously we demonstrated that for full ML expression, a four-stage preclinical sequence is required, namely (1) suppression, (2) recovery, (3) accommodation, and (4) preleukemic transition. Within this pathological sequence, a critical early event has been identified as the acquisition of radioresistance by hematopoietic progen… more
Date: January 1, 1990
Creator: Seed, T.M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Endogenous retrovirus and radiation-induced leukemia in the RMF mouse

Description: The induction of myeloid leukemia in irradiated RFM/Un mice has been associated with retrovirus infection. However, two characteristics of this strain complicate efforts to define the role of the virus. This strain possesses only one inducible host range class of endogenous virus and a unique gene, in addition to the Fv-1/sup n/ locus, which specifically restricts exogenous infection by endogenous viruses. These characteristics possibly account for absence of recombinant viruses in this strain,… more
Date: January 1, 1982
Creator: Tennant, R. W.; Boone, L. R.; Lalley, P. & Yang, W. K.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Health effects models for nuclear power plant accident consequence analysis: Modifications of models resulting from recent reports on health effects of ionizing radiation

Description: The Nuclear Regulatory Commission has sponsored several studies to identify and quantify the potential health effects of accidental releases of radionuclides from nuclear power plants. The most recent health effects models resulting from these efforts were published in two reports, NUREG/CR-4214, Rev. 1, Part 1 (1990) and Part 2 (1989). Several major health effects reports have been published recently that may impact the health effects models presented in these reports. This addendum to the Par… more
Date: August 1, 1991
Creator: Abrahamson, S.; Bender, M. A.; Boecker, B. B.; Scott, B. R. & Gilbert, E. S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Effects of chemical carcinogens of hemopoiesis, immunopoiesis and viral oncogenesis. Technical progress report, December 1, 1977--September 30, 1978. [Mechanisms of potentiation of viral leukemogenesis by MMS, benzopyrene, and DMBA]

Description: During the past year we have concentrated on defining the circumstances under which methyl methanesulfonate (MMS), benzo(a) pyrene (BP), and 7,12-dimethylbenz(a)anthracene (DMBA) interact with Friend virus (FLV) to produce leukemia. The optimum scheduling for each and also the effective dose levels of the chemicals have been partially determined. There are at least three critical factors which govern whether or not a leukemogenic interaction can be shown between the chemical agents and the viru… more
Date: October 1, 1978
Creator: OKunewick, J.P.; Raikow, R.B. & Meredith, R.F.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

What Has Happened to the Survivors of the Early Los Alamos Nuclear Accidents?

Description: Abstract: Two nuclear accidents involving a plutonium sphere just subcritical in size occurred at the Los Alamos Laboratory, LA-1 in 1945 and LA-2 in 1946. Because remote control devices were deemed unreliable at the time, the tamper material (tungsten carbide bricks in LA-1 and beryllium hemispheres in LA-2) was added by hand with the operator standing next to the assembly. In each case the critical size of the assembly was accidentally exceeded and the resultant exponentially increasing chain… more
Date: 1979
Creator: Hempelman, Louis Henry; Lushbaugh, Clarence C. & Voelz, George L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Risk from fast neutron exposure. [Discussing of Rossi and Mays' paper on acceptable neutron dose limits in relation to leukemogenesis]

Description: The recommendations made by Rossi and Mays imply that the risk associated with the current annual dose equivalent limit of 5 rem for all radiations is unacceptably high, that this limit must be reduced by a factor of 10 or more, and that the conservative linear, no threshold hypothesis must be abandoned. It is shown here that these recommendations are not supported by the newly-analyzed neutron data, and certainly cannot be applied selectively to the annual absorbed dose limit for neutrons. In … more
Date: January 1, 1978
Creator: Bond, V.P.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Radiation-Induced Leukemia: Comparative Studies in Mouse and Man

Description: We now have a clear understanding of the mechanism by which radiation-induced (T-cell) leukemia occurs. In irradiated mice (radiation-induced thymic leukemia) and in man (acute lymphoblastic T-cell leukemia, T-ALL) the mechanism of leukemogenesis is surprisingly similar. Expressed in the most elementary terms, T-cell leukemia occurs when T-cell differentiation is inhibited by a mutation, and pre-T cells attempt but fail to differentiate in the thymus. Instead of leaving the thymus for the perip… more
Date: January 1, 1991
Creator: Haas, M.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Probing altered hematopoietic progenitors of preleukemic dogs with JANUS fission neutrons

Description: Toward the goal of developing basic insights to mechanisms of radiation leukemogenesis, the authors have developed a canine model that responds to protracted courses of low-daily-dose gamma irradiation with high incidences of myeloproliferative disease (MPD), principally myeloid leukemia. Using this model system, the authors have identified and partially characterized a four-phase preclinical sequence in the induction of MPD, including (1) suppression, (2) recovery, (3) accommodation, and (4) p… more
Date: January 1, 1990
Creator: Seed, T.M. & Kaspar, L.V.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Splenic sequestration of Tc-99m labeled heat treated red blood cells. [Feasibility of use for spleen imaging]

Description: The rate of blood clearance and spleen uptake as well as the total spleen uptake of heat damaged red blood cells labeled with Tc-99m was determined in eight patients, six of whom had chronic lymphatic leukemia, one had polycythemia vera and one had eosinophilia of unknown origin. Spleen uptake at 2 hrs was 72.0 +- 18.5%. Approximately 82.6% of the initial radioactivity was cleared from the blood by 2 hrs with a rapid T 1/2 component of 6.3 +- 4.7 min. The T 1/2 of splenic uptake was 8.3 +- 4.6 … more
Date: January 1, 1979
Creator: Atkins, H. L.; Goldman, A. G.; Fairchild, R. G.; Oster, Z. H.; Som, P.; Richards, P. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Effects of chemical carcinogens on hemopoiesis, immunopoiesis and viral oncogenesis. Three year technical progress report, February 1, 1977-September 30, 1979. [MMS; BP; DMBA; propane sultone; MCA; mice]

Description: Studies were initiated to evaluate in an in vitro system selected chemical carcinogens derived from energy producing hydrocarbons for their effect on the hematopoietic and immune systems. Studies were also conducted to determine whether the selected carcinogens could interact with leukemogenic virus to produce leukemia in mice. Five compounds have been investigated thus far: (1) methylmethane sulfonate (MMS); (2) benzo(a)pyrene (BP); (3) 7,12 dimethylbenz(a)anthracene (DMBA); (4) propane sulton… more
Date: September 1, 1979
Creator: OKunewick, J.P.; Raikow, R.B. & Meredith, R.F.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Research and development program, fiscal year 1970

Description: The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1970 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine Prog… more
Date: April 1, 1968
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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