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in subjects: "Indium Isotopes"

open access

Harvard-MIT research program in short-lived radiopharmaceuticals

This report presents research on radiopharmaceuticals. The following topics are discussed: antibody labeling with positron-emitting radionuclides; antibody modification for radioimmune imaging; labeling antibodies; evaluation of technetium acetlyacetonates as potential cerebral blood flow agents; and studies in technetium chemistry. (CBS)

Date: January 1, 1991

Creator: Adelstein, S.J.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Neutron flux measurements around PLT

Using Indium activation foils, the toroidal and poloidal neutron emission patterns were determined for PLT plasmas which include ICRF and neutral beam heating. The activities produced the /sup 115/In (n,n') /sup 115m/In reaction were determined by counting the 336 keV ..gamma.. line of the /sup 115m/In decay. This activation cross section falls just below 2.5 MeV so that the influence of scattered neutrons of degraded energies is reduced. From the magnitude of the activity, the absolute calibra… more

Date: September 1, 1980

Creator: Zankl, G.; Strachan, J.D.; Lewis, R.; Pettus, W. & Schmotzer, J.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Long-lived light mass element half-lives (A < 125)

Reported values of half-lives of light and intermediate mass elements are evaluated. The evaluation analysis estimates the systematic error and the resulting standard deviation. Recommended values are then presented for tritium, /sup 10/Be, /sup 14/C, /sup 26/Al, /sup 39/Ar, /sup 40/K, /sup 50/V, /sup 53/Mn, /sup 76/Ge, /sup 87/Rb, /sup 92/Nb, /sup 107/Pd, /sup 113/Cd, /sup 115/In, and /sup 123/Te. 106 refs., 15 tabs. (WRF)

Date: January 1, 1985

Creator: Holden, Norman E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Light mass elements total half-lives for selected long-lived nuclides

In the past, many compilations and evaluations of half-lives have been made which have uncritically accepted authors' values and uncertainties. They have merely recommended weight-averaged reported results. This evaluation attempts to reanalyze each experiment in the literature including an estimate of the standard deviation utilizing, where possible, an estimate of the systematic error. This paper constitutes a preliminary step in the process of recommending values. The long-lived nuclides of … more

Date: January 1, 1985

Creator: Holden, Norman E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Improved radioimmunotherapy of hematologic malignancies

This research project proposes to develop novel new approaches of improving the radioimmunodetection and radioimmunotherapy of malignancies by augmenting retention of radioimmunoconjugates by tumor cells. The approaches shown to be effective in these laboratory experiments will subsequently be incorporated into out ongoing clinical trials in patients. Specific project objectives include: to study the rates of endocytosis, intracellular routing, and metabolic degradation of radiolabeled monoclon… more

Date: March 24, 1992

Creator: Press, O.W.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

State of the science of blood cell labeling

Blood cell labeling can be considered a science in as far as it is based on precise knowledge and can be readily reproduced. This benchmark criterion is applied to all current cell labeling modalities and their relative merits and deficiencies are discussed. Mechanisms are given where they are known as well as labeling yields, label stability, and cell functionality. The focus is on the methodology and its suitability to the clinical setting rather than on clinical applications per se. Clinical… more

Date: January 1, 1989

Creator: Srivastava, S. C. & Straub, R. F.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Biomedical research with cyclotron produced radionuclides. Progress report, February 1, 1981-December 31, 1981

Progress is reported in the following areas: evaluation of chemotherapeutic regimens in solid tumors using /sup 13/N-labelled amino acids; organ imaging with /sup 13/N-labelled L-amino acids; imaging with /sup 111/In-labelled-autologous platelets; synthesis and biological studies of /sup 111/In-labelled ammonia and L-amino acids; synthesis and evaluation for pancreatic imaging of /sup 11/C-labelled amino acides; radioisotope monitoring of myocardiol function; synthesis of /sup 11/C-labelled pre… more

Date: September 1, 1981

Creator: Laughlin, J.S.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Investigations into agents for improving cell labeling with positron- and gamma-emitting radionuclides

It was possible to label leukocytes with Co-oxine, but a large proportion of the radioactivity was eluted from the cells upon washing. Ruthenium oxine labeled platelets efficiently in plasma while negligible proportion of radioactivity was eluted from the cells. Three factors influence the labeling efficiency of the cells: duration of the incubation periods; cell concentration; and ACD concentration.

Date: January 1, 1982

Creator: Zoghbi, S. S.; Thakur, M. L.; Gottschalk, A.; Pande, S.; Srivastava, S. C. & Richards, P.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Criteria for the selection of radionuclides for tumor radioimmunotherapy

The potential of utilizing monoclonal antibodies as carriers of radionuclides for the selective destruction of tumors (radioimmunotherapy, RIT) has stimulated much research activity. From dosimetric and other considerations, the choice of radiolabel is an important factor that needs to be optimized for maximum effectiveness of RIT. This paper reviews and assesses a number of present and future radionuclides that are particularly suitable for RIT based on the various physical, chemical, and biol… more

Date: January 1, 1991

Creator: Srivastava, S.C.; Mausner, L.F. & Mease, R.C.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Radiolabeled red blood cells: status, problems, and prospects

Radionuclidic labels for red cells can be divided into two main categories - cohort or pulse labels, and random labels. The random labels are incorporated into circulating cells of all ages and the labeling process is usually carried out in vitro. The red cell labels in predominant use involve random labeling and employ technetium-99m, chromium-51, indium-111, and gallium-68, roughly in that order. The extent of usefulness depends on the properties of the label such as the half-life, decay mode… more

Date: January 1, 1983

Creator: Srivastava, S.C.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Studies of yrast and continuum states in A = 100--200 nuclei

This report summarizes progress in nuclear structure research for the year 1991. The highlights include new spectroscopic results for neutron excessive nuclei (around {sup 124}Sn and {sup 36}S) formed in deep inelastic heavy ion reactions.

Date: February 1, 1992

Creator: Daly, P. J.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

The development of in vitro mutagenicity testing systems using T-lymphocytes

This annual report describes progress in studies on hprt mutations induced by radon or Indium 111 along with the corresponding mutation frequency, cloning and molecular spectra in human T-lymphocytes. Parallel studies on the mutation susceptibility between individuals is being investigated by hprt mutation studies on ataxia telangiectasia and xeroderma pigmentosum.

Date: May 1, 1993

Creator: Albertini, R.J.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Comparative biokinetics of radiogallium and radioindium in mice

The biokinetics of radiogallium and radioindium in normal mice are compared using the compartmental modelling analysis. The rate constants obtained provide useful information in understanding the physiological and biochemical kinetics of radionuclides in the intact object. A comparison of the compartmental models for gallium and indium reveals the similarities and differences between the biokinetics of the two radionuclides. Furthermore, the results provide valuable information and guidance for… more

Date: January 1, 1978

Creator: Tsui, B.M.W. & Lathrop, K.A.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Dosimetry of Auger emitters: Physical and phenomenological approaches

Recent radiobiological studies have demonstrated that Auger cascades can cause severe biological damage contrary to expectations based on conventional dosimetry. Several determinants govern these effects, including the nature of the Auger electron spectrum; localized energy deposition; cellular geometry; chemical form of the carrier; cellular localization, concentration, and subcellular distribution of the radionuclide. Conventional dosimetry is inadequate in that these considerations are ignor… more

Date: January 1, 1987

Creator: Sastry, K. S. R.; Howell, R. W.; Rao, D. V.; Mylavarapu, V. B.; Kassis, A. I.; Adelstein, S. J. et al.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Correlating labeling chemistry and in-vitro test results with the biological behavior of radiolabeled proteins

Monoclonal antibodies possess enormous potential for delivery of therapeutic amounts of radionuclides to target antigens in vivo, in particular for tumor imaging and therapy. Translation of this concept into practice has encountered numerous problems. Specifically whereas general protein radiolabeling methods are applicable to antibodies, immunological properties of the antibodies are often compromised resulting in reduced in-vivo specificity for the target antigens. The bifunctional chelating … more

Date: January 1, 1985

Creator: Srivastava, S. C. & Meinken, G. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

In-situ verification techniques for fast critical assembly cores

Active and passive autoradiographic techniques were used to obtain piece counts of fuel plates in fast critical assembly drawers and to verify the assembly loading pattern. Active autoradiography using prompt-fission and fission-product radiation was more successful with uranium fuel while passive autoradiography was more successful with plutonium fuel. A source multiplication technique was used to measure changes in reactivity when small quantities (2-2.5 kg) of fissile material were removed f… more

Date: January 1, 1979

Creator: Brumbach, S. B.; Amundson, P. I. & Roche, C. T.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Effect of transport in distribution of radioions and radiolabeled metabolites

The following topics are discussed: route of administration; carrier effects and complexed or ionic tracers; membrane permeability, extracellular and intracellular concentrations; enzyme and hormonal stimulation or depression and the metabolic state; neoplasia and transport; and carrier for radiopharmaceutical binding to membrane or protein sites. Some radioisotopes considered are /sup 99m/Tc, /sup 65/Zn, /sup 62/Zn, /sup 14/C and /sup 111/In. (HLW)

Date: December 22, 1977

Creator: Yano, Y.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Biodistribution of Ru-97-Labeled DTPA, DMSA and Transferrin. [Diagnostic Potential]

Ruthenium-97 is being produced at the Brookhaven Linac Isotope Producer (BLIP). The favorable physical properties of Ru-97 and chemical reactivity of ruthenium offer a potential for using this isotope to label compounds useful for delayed scanning. Diethylenetriamine pentaacetic acid (DTPA), 2,3-Dimercaptosuccinic acid (DMSA), and Transferrin (TF) were labeled with Ru-97-chloride. Ru-97-DTPA and In-111-DTPA, injected intravenously, showed similar organ distribution, kinetics, and more than 80% … more

Date: January 1, 1980

Creator: Som, P.; Oster, Z. H.; Fairchild, R. G.; Atkins, H. L.; Brill, A. B.; Gil, M. C. et al.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

(Bifunctional chelates of Rh-105, Au-199, and other metallic radionuclides as potential radiotherapeutic agents)

Progress during this period is reported under the following headings: Diethylenetriamine based and related bifunctional chelating agents and their complexation with Rh-105, Au-198, Pd-109, cu-67, In-111, and Co-57; studies of Pd-109, Rh-105 and Tc-99m with bifunctional chelates based on phenylenediamine; establishment of an appropriate protein assay method for conjugated proteins; studies of new bifunctional Bi, Tri and tetradentate amine oxime ligands with Rh-105; IgG and antibody B72.3 conjug… more

Date: January 1, 1991

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Complex fragment emission at low and high excitation energy

Complex fragment emission has been certified as a compound nucleus process at low energies. An extension of the measurements to heavy ion reactions up to 50 MeV/u shows that most complex fragments are emitted by highly excited compound nuclei formed in incomplete fusion reactions. 12 refs., 26 figs.

Date: August 1, 1986

Creator: Moretto, Luciano G.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Interactive radiopharmaceutical facility between Yale Medical Center and Brookhaven National Laboratory. Progress report, November 1, 1980-October 31, 1981

Research conducted in three principal areas is discussed and summarized. (1) Investigation of the influence of antiarrhythmic agents, such as lidocaine and procainamide, on the chemotaxis and nylon fiber adherence of indium-111-labelled human polymorphonulcear leukocytes (PMNs) in vitro revealed that at normal therapeutic levels of lidocaine and procaine, the adherence and chemotactic function of In-111-PMNs remain unaltered. Results with higher therapeutic blood levels are also discussed. (2) … more

Date: unknown

Creator: Gottschalk, A.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Labeling cellular elements of blood with Technetium-99m

The purpose of this proposal is to develop new technique of labeling platelets and white cells with Tc-99m radionuclide. The conditions of labeling canine platelets and white cells with the lipid-soluble Tc-99m HMPAO have been optimized. The function of labeled platelets were evaluated by the determination of platelet survival time and recovery and these values were compared with that of In-111 tropolone labeled platelets. We developed the bilateral femoral catheterization model for the evaluat… more

Date: August 1, 1990

Creator: Dewanjee, M.K.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Non-invasive nuclear detection of choroidal melanoma

The biodistribution of over 30 radiopharmaceuticals thought to be tumor-seeking agents were studied using hamsters and mice. Several radiopharmaceuticals were found to be appropriate as melanoma localizing agents. Results with modified dual pinhole collimator and a pigment affinic agent (iodine-123 labeled quinoline) and a non-specific tumor seeking agent (gallium-67 citrate) are also reported.

Date: January 1, 1981

Creator: Packer, S.; Lambrecht, R.M.; Fairchild, R.G.; Wolf, A.P.; Atkins, H.L. & Fand, I.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Beta decays of /sup 126/Cd and /sup 126/In to levels in /sup 126/In and /sup 126/Sn. [J,. pi. ]

A study of the beta decays of /sup 126/Cd and /sup 126/In using the TRISTAN on-line isotope separator facility is reported. Gamma-ray singles measurements were made for both decays usng Ge(Li) and LEPS (low energy photon spectrometer) detectors. In addition, gamma--gamma coincidence measurements and gamma multiscale measurements were made for both decays using Ge(Li) detectors. The half-life for /sup 126/Cd was determined to be 0.506 +- 0.015 sec., and the half-lives for the low- and high-spin … more

Date: January 1, 1979

Creator: Gartner, M.L.

Item Type: Report

Partner: UNT Libraries Government Documents Department