Dosimetry of Auger emitters: Physical and phenomenological approaches

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Recent radiobiological studies have demonstrated that Auger cascades can cause severe biological damage contrary to expectations based on conventional dosimetry. Several determinants govern these effects, including the nature of the Auger electron spectrum; localized energy deposition; cellular geometry; chemical form of the carrier; cellular localization, concentration, and subcellular distribution of the radionuclide. Conventional dosimetry is inadequate in that these considerations are ignored. Our results provide the basis for biophysical approaches toward subcellular dosimetry of Auger emitters in vitro and in vivo. 12 refs., 7 figs., 2 tabs.

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Pages: 13

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Sastry, K.S.R.; Howell, R.W.; Rao, D.V.; Mylavarapu, V.B.; Kassis, A.I.; Adelstein, S.J. et al. January 1, 1987.

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Description

Recent radiobiological studies have demonstrated that Auger cascades can cause severe biological damage contrary to expectations based on conventional dosimetry. Several determinants govern these effects, including the nature of the Auger electron spectrum; localized energy deposition; cellular geometry; chemical form of the carrier; cellular localization, concentration, and subcellular distribution of the radionuclide. Conventional dosimetry is inadequate in that these considerations are ignored. Our results provide the basis for biophysical approaches toward subcellular dosimetry of Auger emitters in vitro and in vivo. 12 refs., 7 figs., 2 tabs.

Physical Description

Pages: 13

Notes

NTIS, PC A03; 3.

Source

  • Workshop on aspects of dosimetry of internally incorporation Auger emitters, Harwell, UK, 17 Jul 1987

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  • Other: DE88002786
  • Report No.: CONF-8707137-1
  • Grant Number: AC05-84OR21400
  • Office of Scientific & Technical Information Report Number: 5606399
  • Archival Resource Key: ark:/67531/metadc1092238

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  • January 1, 1987

Added to The UNT Digital Library

  • Feb. 10, 2018, 10:06 p.m.

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  • Feb. 22, 2018, 8:53 p.m.

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Sastry, K.S.R.; Howell, R.W.; Rao, D.V.; Mylavarapu, V.B.; Kassis, A.I.; Adelstein, S.J. et al. Dosimetry of Auger emitters: Physical and phenomenological approaches, article, January 1, 1987; United States. (digital.library.unt.edu/ark:/67531/metadc1092238/: accessed November 13, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.