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Naloxone Potentiation of Epinephrine Induced Vasoconstriction in Canine Skeletal Muscle Arteries

Description: Naloxone (NX) potentiated epinephrine (EPI) induced submaximal vasoconstriction in canine renal and skeletal muscle arterial segments, yet had no vasoconstrictor action alone. Developed tension generated in-vitro by 4 x 1mm. O.D. rings from 1st degree branches of canine femoral arteries was expressed as % of KCI induced maximum response. NX (10^-5 M) potentiated EPI induced submaximal contractions (34.2%) significantly more than contractions induced by norepinephrine, phenylephrine, lofexidine,… more
Date: August 1992
Creator: Stoll, Scott Thomas
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Ocular Hypotensive Effect of the α2-Adrenergic Agonist, Lofexidine

Description: A selective a2-adrenergic agonist, lofexidine, significantly reduced intraocular pressure (lOP) in intact ocular normotensive NZW rabbits, producing a differential dose-dependent decrease in IOP in'the ipsilateral and contralateral eye. Contralateral IOP reduction was most observable at low doses. Unilateral superior cervical ganglionectomy and extraocular muscle excision studies were undertaken to elucidate the factors influencing differential IOP reduction by lofexidine. Similar significant c… more
Date: August 1989
Creator: Tran, Tung Vu
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Protein Kinase C Activation in Hyperglycemic Bovine Lens Epithelial Cells

Description: This study demonstrates the presence of protein kinase C activity in both cytosolic and membrane fractions of bovine lens epithelial cells in culture. Protein kinase C activity is similar in normal and hyperglycemic cells. Furthermore, the ability of the enzyme to translocate from the cytosol to the membrane following phorbol ester treatment is unimpeded by hyperglycemic conditions. Moreover, protein kinase C activation had no effect on myoinositol uptake either in normal cells or in cells expo… more
Date: December 1993
Creator: Fan, Wen-Lin
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Role of Calcium and Phospholipids in Transepithelial Sodium Ion and Water Transport in Amphibian Epithelia

Description: The present investigation is concerned with determining the role of calcium, phospholipids, and phospholipid metabolites on transepithelial sodium and water transport in response to antidiuretic hormone (ADH). These studies utilize the frog skin for determining sodium transport and amphibian urinary bladder for water flow measurements and scanning electron microscopy of cell surface morphology. The results demonstrate that phospholipids and phospholipid metabolites containing arachidonic acid s… more
Date: August 1983
Creator: Tarapoom, Nimman
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Modulation of ³H-Myo-Inositol Uptake by Glucose and Sorbitol in Cultured Bovine Lens Epithelial Cells

Description: Myo-[3H]-inositol accumulation in cultured bovine lens epithelial cells (BLECs) occurred by both high- and low affinity, Nat-dependent transport sites. High ambient glucose significantly inhibited myo-[ 3 H]-inositol uptake; the co-administration of sorbinil, an aldose reductase inhibitor, prevented the inhibitory effect on the low affinity transport site. A glucose-sensitive process for myo-[3 H]-inositol uptake on the high-affinity transport site was uncovered by Lineweaver-Burk analysis. Dix… more
Date: August 1992
Creator: Chen, Hai-Qing
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Fumarate Activation and Kinetic Solvent Isotope Effects as Probes of the NAD-Malic Enzyme Reaction

Description: The kinetic mechanism of activation of the NAD-malic enzyme by fumarate and the transition state structure for the oxidation malate for the NAD-malic enzyme reaction have been studied. Fumarate exerts its activating effect by decreasing the off-rate for malate from the E:Mg:malate and E:Mg:NAD:malate complexes. The activation by fumarate results in a decrease in K_imalate and an increase in V/K_malate by about 2-fold, while the maximum velocity remains constant. A discrimination exists between … more
Date: December 1992
Creator: Lai, Chung-Jeng
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor

Description: This study examined the effects of chronic ethanol intake on the density, affinity, and allosteric modulation of rat brain GABAA receptor subtypes. In the presence of GABA, the apparent affinity for the benzodiazepine agonist flunitrazepam was increased and for the inverse agonist R015-4513 was decreased. No alteration in the capacity of GABA to modulate flunitrazepam and R015-4513 binding was observed in membranes prepared from cortex, hippocampus or cerebellum following chronic ethanol intake… more
Date: May 1992
Creator: Chen, Jianping
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase from Swine Kidney: Characterization and Kinetic Mechanism

Description: Cytoplasmic 15-hydroxyprostaglandin dehydrogenase from swine kidney was purified to specific activity of 1.2 U per mg protein, by chromatographic techniques. Native molecular weight of enzyme was estimated at 45,000. Enzyme was inhibited by sulfhydryls, diuretics, and various fatty acids. Substrate studies indicated NAD+ specificity and ability to catabolize prostaglandins, except prostaglandin B and thromboxane B. Initial velocity studies gave intersecting plots conforming to a sequential mec… more
Date: December 1979
Creator: Kung-Chao, Diana T.-Y.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Fluoride-Induced Changes in In Vivo Papillary Cyclic AMP

Description: Two separate experiments were designed to measure urinary cyclic AMP and renal papillary cyclic AMP, respectively, Results suggest that urinary cyclic AMP excretion rate is unchanged and cannot be used as an index of tubular sensitivity to either vasopressin or fluoride. However, renal papillary tissue cyclic AMP increased significantly (p<0.05) at plasma fluoride concentrations which result in polyuric renal failure. Further, it appears that fluoride independently stimulates cyclic AMP in the … more
Date: December 1982
Creator: Maxwell, Jack Allen
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Toxicological Evaluation for the Ocular Administration of Tolrestat: An Aldose Reductase Inhibitor for the Treatment of Diabetes

Description: Aldose reductase inhibitors (ARI's) have been shown to attenuate or prevent several complications of diabetes in animals. Tolrestat is a potent and unique ARI from Ayerst Laboratories, New York, NY. The efficacy and toxicology of tolrestat via topical ocular administration was examined. Tolrestat effectively enhanced corneal reepithelialization and was efficacious in the prevention of cataracts in the streptozotocin-diabetic rat. Ocular tissues were examined by slit lamp biomicroscopy, scanning… more
Date: December 1987
Creator: Carney, Gerald R.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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