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Teratology studies of lewisite and sulfur mustard agents: Effects of lewisite in rats and rabbits: Final report

Description: Lewisite was administered to rats and rabbits by intragastric intubation. Maternal animals were weighed periodically, and, at necropsy (20 dg (days of gestation) in rats and 30 dg in rabbits), were examined for gross lesions of major organs and reproductive performances; live fetuses were weighed and examined for external, internal and skeletal defect. In rats, a dose level of 1.5 mg/kg did not induce toxic or teratogenic responses in maternal and fetal body weights and a significant reduction … more
Date: December 31, 1987
Creator: Hackett, P L; Sasser, L B; Rommereim, R L; Cushing, J A; Buschbom, R L & Kalkwarf, D R
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The role of high-energy synchrotron radiation in biomedical trace element research

Description: This paper will present the results of an investigation of the distribution of essential elements in the normal hepatic lobule. the liver is the organ responsible for metabolism and storage of most trace elements. Although parenchymal hepatocytes are rather uniform histologically, morphometry, histochemistry, immunohistochemistry, and microdissection with microchemical investigations have revealed marked heterogeneity on a functional and biochemical level. Hepatocytes from the periportal and pe… more
Date: January 1, 1987
Creator: Pounds, J. G.; Long, G. J.; Kwiatek, W. M.; Jones, K. W.; Gordon, B. M. & Hanson, A. L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Inhalation developmental toxicology studies: Teratology study of n-hexane in rats: Final report

Description: The straight chain hydrocarbon, n-hexane, is a volatile, ubiquitous solvent used in industrial, academic, and smaller commercial environments. The significant opportunity for women of child-bearing age to be exposed to this chemical prompted the undertaking of a study to assess the developmental toxicity of n-hexane in an animal model. Timed-pregnant (30 animals per group) and virgin (10 animals per group) Sprague-Dawley rats were exposed to 0 (filtered air), 200, 1000, and 5000 ppM n-hexane (9… more
Date: December 1, 1987
Creator: Mast, T.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Water quality criteria for colored smokes: Solvent Yellow 33, Final report. [Contains glossary]

Description: The available data on the environmental fate, aquatic toxicity, and mammalian toxicity of Solvent Yellow 33, a quinoline dye used in colored smoke grenades, were reviewed. The US Environmental Protection Agency (USEPA) guidelines were used in an attempt to generate water quality criteria for the protection of aquatic life and its use and of human health. 87 refs., 2 figs., 13 tabs.
Date: November 1, 1987
Creator: Davidson, K.A. & Hovatter, P.S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Lactation-induced cadmium-binding proteins

Description: Previously we have demonstrated an increase during midlactation in /sup 109/Cd adsorption and increased retention by the duodenum, kidney, and mammary tissue of mouse dams receiving environmental levels of cadmium//sup 109/Cd via drinking water, with little change in /sup 109/Cd retention in liver and jejunum compared to nonpregnant controls. Results are reported here of a study of cadmium deposition during midlactation as associated with induction of metallothionein (MT). A cadmium/hemoglobin … more
Date: January 1, 1987
Creator: Bhattacharyya, M.H.; Solaiman, D.; Garvey, J.S. & Miyazaki, W.Y.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Experimental studies of the early effects of inhaled beta-emitting radionuclides for nuclear accident risk assessment: Phase 2 report

Description: This report summarizes a series of experiments concerning the effect of linear energy transfer and temporal radiation dose pattern to the lung from inhaled beta-emitting radionuclides. The results were used to test the validity of a hazard-function mathematical model for predicting death from radiation pneumonitis. Both morbidity and mortality within 18 months after exposure were examined in rats exposed to beta-emitting radionuclides, giving brief or protracted irradiation of the lung or havin… more
Date: November 1, 1987
Creator: Scott, B. R.; Hahn, F. F.; Newton, G. J.; Snipes, M. B.; Damon, E. G.; Mauderly, J. L. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Inhalation developmental toxicology studies of 1,3-butadiene in the rat: Final report

Description: Maternal toxicity, reproductive performance and developmental toxicology were evaluated in Sprague-Dawley-derived rats during and following 6 hours/day, whole-body, inhalation exposures to 0, 40, 200, and 1000 ppM of 1,3-butadiene. The female rats (Ns = 24 to 28), which had mated with unexposed males, were exposed to the chemical from 6 through 15 dg and sacrificed on 20 dg. Maternal animals were weighed prior to mating and on 0, 6, 11, 16 and 20 dg; the rats were observed for mortality, morbid… more
Date: November 1, 1987
Creator: Hackett, P. L.; Sikov, M. R.; Mast, T. J.; Brown, M. G.; Buschbom, R. L.; Clark, M. L. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

New radiohalogenated alkenyl tellurium fatty acids

Description: Radiolabeled long-chain fatty acids have diagnostic value as radiopharmaceutical tools in myocardial imaging. Some applications of these fatty acids are limited due to their natural metabolic degradation in vivo with subsequent washout of the radioactivity from the myocardium. The identification of structural features that will increase the myocardial residence time without decreasing the heart uptake of long-chain fatty acids is of interest. Fatty acids containing the tellurium heteroatom were… more
Date: January 1, 1987
Creator: Srivastava, P. C.; Knapp, F. F. Jr. & Kabalka, G. W.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Radiation effects in space

Description: As more people spend more time in space, and the return to the moon and exploratory missions are considered, the risks require continuing examination. The effects of microgravity and radiation are two potential risks in space. These risks increase with increasing mission duration. This document considers the risk of radiation effects in space workers and explorers. 17 refs., 1 fig., 4 tabs.
Date: July 1, 1987
Creator: Fry, R.J.M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Reconfigured, close-coupled reconfigured, and Wyodak coal integrated two-stage coal liquefaction process materials from the Wilsonville facility: Chemical and toxicological evaluation

Description: This document reports the results of the chemical analysis and toxicological testing of process materials sampled during the operation of the Advanced Coal Liquefaction Research and Development Facility (Wilsonville, AL) in the reconfigured, integrated (RITSL run No. 247), the close-coupled, reconfigured, integrated (CCRITSL run No. 249), and the Wyodak coal integrated (ITSL run No. 246) two-stage liquefaction operating modes. Chemical methods of analysis included proton nuclear magnetic resona… more
Date: March 1, 1987
Creator: Wright, C.W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Microimaging studies of myocardial substrate utilization and perfusion in two models of non-coronary heart disease

Description: We have studied two animal models of non-coronary heart disease. The salt-sensitive Dahl strain hypertensive rats and their genetically matched normotensive controls and the cardiomyopathic BIO 53.58 (CM) strain Syrian hamsters with age and sex-matched RB strain controls. The CM strain hamster seems to be a very good model of human congestive cardiomyopathy and the Dahl strain hypertensive rats have also been found to be good models for studying the effects of hypertension on the myocardium. In… more
Date: January 1, 1987
Creator: Som, P.; Oster, Z. H. & Knapp, F. F. Jr.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Biological efficacy of a boronated porphyrin as measured in cell culture

Description: Attempts to develop a boronated porphyrin analog have suffered from problems associated with toxicity, solubility and, upon occasion, lability of the boron tag. One compound synthesized by one of us (SBK), designated ''SBK-II'', has evidently overcome the above problems, providing therapeutic amounts of boron in animal tumor models (20-40 ..mu..g B/g tumor) with retention times in the order of weeks. As is well known, biological efficacy will depend upon distribution within (or without) the cel… more
Date: January 1, 1987
Creator: Laster, B. H.; Kahl, S. B.; Kalef-Ezra, J.; Popenoe, E. A. & Fairchild, R. G.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Data base on animal mortality

Description: A data base on animal mortality has been compiled. The literature on LD/sub 50/ and the dose-response function for radiation-induced lethality, reflect several inconsistencies - primarily due to dose assignments and to analytical methods and/or mathematical models used. Thus, in order to make the individual experiments which were included in the data base as consistent as possible, an estimate of the uniform dose received by the bone marrow in each treatment group was made so that the interspec… more
Date: January 1, 1987
Creator: Jones, T.D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Work performance evaluation using the exercising rat model

Description: A treadmill-metabolic chamber system and a stress testing protocol have been developed to evaluate aerobic work performance on exercising rats that have inhaled toxic substances. The chamber with an enclosed treadmill provides the means to measure the physiologic status of rats during maximal work intensities in terms of O/sub 2/ consumption (V/sub 02/) and CO/sub 2/ production (V/sub c02/). The metabolic chamber can also accommodate instrumented rats for more detailed analyses of their cardiop… more
Date: January 1, 1987
Creator: Stavert, D. M. & Lehnert, B. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Teratology studies of lewisite and sulfur mustard agents: Effects of lewisite in rats and rabbits: Final report: Part 2, Appendices

Description: Lewisite was administered to rats and rabbits by intragastric intubation. Maternal animals were weighed periodically, and, at necropsy (20 dg (days of gestation) in rats and 30 dg in rabbits), were examined for gross lesions of major organs and reproductive performances; live fetuses were weighed and examined for external, internal and skeletal defects. In rats, a dose level of 1.5 mg/kg did not induce toxic or teratogenic responses in maternal animals or their fetuses. At 2.0 mg/kg, 10% matern… more
Date: December 31, 1987
Creator: Hackett, P. L.; Sasser, L. B.; Rommereim, R. L.; Cushing, J. A.; Buschbom, R. L. & Kalkwarf, D. R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Radiolabeled porphyrin versus gallium-67 citrate for the detection of human melanoma in athymic mice

Description: We performed the biodistribution and imaging studies of /sup 111/In and /sup 67/Ga labeled tetra(4-N-methylpyridyl) porphine, (T4NMPYP), and compared it to that of /sup 67/Ga citrate in athymic mice bearing a human melanoma xenograft. The biodistribution results of both /sup 111/In and /sup 67/Ga labeled T4NMPYP (3, 6, 24, and 48 hours) were similar but differed from that of /sup 67/Ga citrate (48 hours). The optimum tumor uptake of both radiolabeled porphyrins was at 6 hours postinjection and … more
Date: January 1, 1987
Creator: Maric, N.; Chan, S. Ming; Hoffer, P. B. & Duray, P.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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