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Dose-dependent misrejoining of radiation-induced DNA double-strand breaks in human fibroblasts: Experimental and theoretical study for high and low LET radiation

Description: Misrejoining of DNA double-strand breaks (DSBs) was measured in human primary fibroblasts after exposure to X-rays and high LET particles (He, N and Fe) in the dose range 10-80 Gy. To measure joining of wrong DNA ends, the integrity of a 3.2 Mbp restriction fragment was analyzed directly after exposure and after 16 hr of repair incubation. It was found that the misrejoining frequency for X-rays was non-linearly related to dose, with less probability of misrejoining at low doses than at high dos… more
Date: November 18, 2004
Creator: Rydberg, Bjorn; Cooper, Brian; Cooper, Priscilla K.; Holley, William & Chatterjee, Aloke
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Results of The Analysis of The Blood Beryllium Lymphocyte Proliferation Test Data From The Oak Ridge Y-12 Study

Description: The potential hazards from exposure to beryllium or beryllium compounds in the workplace were first reported in the 1930s. The tritiated thymidine beryllium lymphocyte proliferation test (BeLPT) is an in vitro blood test that is widely used to screen beryllium exposed workers in the nuclear industry for sensitivity to beryllium. Newman [18] has discussed the clinical significance of the BeLPT and described a standard protocol that was developed in the late 1980s. Cell proliferation is measured … more
Date: December 18, 2001
Creator: Frome, EL
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Micro-Raman spectroscopy Detects Individual Neoplastic and Normal Hematopoietic Cells

Description: Current methods for identifying neoplastic cells and discerning them from their normal counterparts are often non-specific, slow, biologically perturbing, or a combination, thereof. Here, we show that single-cell micro-Raman spectroscopy averts these shortcomings and can be used to discriminate between unfixed normal human lymphocytes and transformed Jurkat and Raji lymphocyte cell lines based on their biomolecular Raman signatures. We demonstrate that single-cell Raman spectra provide a highly… more
Date: January 18, 2005
Creator: Chan, J. W.; Taylor, D.; Zwerdling, T.; Lane, S. M.; Ihara, K. & Huser, T.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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