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in creator/contributor: "Lawrence Berkeley National Laboratory. Physical Biosciences Division."  
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Structure-based inference of molecular functions of proteins of unknown function from Berkeley Structural Genomics Center

Description: Advances in sequence genomics have resulted in an accumulation of a huge number of protein sequences derived from genome sequences. However, the functions of a large portion of them cannot be inferred based on the current methods of sequence homology detection to proteins of known functions. Three-dimensional structure can have an important impact in providing inference of molecular function (physical and chemical function) of a protein of unknown function. Structural genomics centers worldwide… more
Date: September 2, 2007
Creator: Kim, Sung-Hou; Shin, Dong Hae; Hou, Jingtong; Chandonia, John-Marc; Das, Debanu; Choi, In-Geol et al.
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Partner: UNT Libraries Government Documents Department
open access

ARCHITECTURE OF A CHARGE-TRANSFER STATE REGULATING LIGHT HARVESTING IN A PLANT ANTENNA PROTEIN

Description: Energy-dependent quenching of excess absorbed light energy (qE) is a vital mechanism for regulating photosynthetic light harvesting in higher plants. All of the physiological characteristics of qE have been positively correlated with charge-transfer between coupled chlorophyll and zeaxanthin molecules in the light-harvesting antenna of photosystem II (PSII). In this work, we present evidence for charge-transfer quenching in all three of the individual minor antenna complexes of PSII (CP29, CP26… more
Date: April 2, 2008
Creator: Fleming, Graham; Ahn, Tae Kyu; Avenson, Thomas J.; Ballottari, Matteo; Cheng, Yuan-Chung; Niyogi, Krishna K. et al.
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Partner: UNT Libraries Government Documents Department
open access

XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations

Description: Mutations in XPD helicase, required for nucleotide excision repair (NER) as part of the transcription/repair complex TFIIH, cause three distinct phenotypes: cancer-prone xeroderma pigmentosum (XP), or aging disorders Cockayne syndrome (CS), and trichothiodystrophy (TTD). To clarify molecular differences underlying these diseases, we determined crystal structures of the XPD catalytic core from Sulfolobus acidocaldarius and measured mutant enzyme activities. Substrate-binding grooves separate adj… more
Date: June 2, 2008
Creator: Tainer, John; Fan, Li; Fuss, Jill O.; Cheng, Quen J.; Arvai, Andrew S.; Hammel, Michal et al.
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Partner: UNT Libraries Government Documents Department
open access

X-ray Emission Spectroscopy to Study Ligand Valence Orbitals in Mn Coordination Complexes

Description: We discuss a spectroscopic method to determine the character of chemical bonding and for the identification of metal ligands in coordination and bioinorganic chemistry. It is based on the analysis of satellite lines in X-ray emission spectra that arise from transitions between valence orbitals and the metal ion 1s level (valence-to-core XES). The spectra, in connection with calculations based on density functional theory (DFT), provide information that is complementary to other spectroscopic te… more
Date: March 2, 2009
Creator: Smolentsev, Grigory; Soldatov, Alexander V; Messinger, Johannes; Merz, Kathrin; Weyhermuller, Thomas; Bergmann, Uwe et al.
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Partner: UNT Libraries Government Documents Department
open access

Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels

Description: The ability to generate microorganisms that can produce biofuels similar to petroleum-based transportation fuels would allow the use of existing engines and infrastructure and would save an enormous amount of capital required for replacing the current infrastructure to accommodate biofuels that have properties significantly different from petroleum-based fuels. Several groups have demonstrated the feasibility of manipulating microbes to produce molecules similar to petroleum-derived products, a… more
Date: December 2, 2009
Creator: Kuk Lee, Sung; Chou, Howard; Ham, Timothy S.; Soon Lee, Taek & Keasling, Jay D.
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Partner: UNT Libraries Government Documents Department
open access

Biofuel alternatives to ethanol: pumping the microbial well

Description: Engineered microorganisms are currently used for the production of food products, pharmaceuticals, ethanol fuel and more. Even so, the enormous potential of this technology has yet to be fully exploited. The need for sustainable sources of transportation fuels has gener-ated a tremendous interest in technologies that enable biofuel production. Decades of work have produced a considerable knowledge-base for the physiology and pathway engineering of microbes, making microbial engineering an ideal… more
Date: December 2, 2009
Creator: Fortman, J. L.; Chhabra, Swapnil; Mukhopadhyay, Aindrila; Chou, Howard; Lee, Taek Soon; Steen, Eric et al.
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Partner: UNT Libraries Government Documents Department
open access

Importance of systems biology in engineering microbes for biofuel production

Description: Microorganisms have been rich sources for natural products, some of which have found use as fuels, commodity chemicals, specialty chemicals, polymers, and drugs, to name a few. The recent interest in production of transportation fuels from renewable resources has catalyzed numerous research endeavors that focus on developing microbial systems for production of such natural products. Eliminating bottlenecks in microbial metabolic pathways and alleviating the stresses due to production of these c… more
Date: December 2, 2009
Creator: Mukhopadhyay, Aindrila; Redding, Alyssa M.; Rutherford, Becky J. & Keasling, Jay D.
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Partner: UNT Libraries Government Documents Department
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