Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels

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The ability to generate microorganisms that can produce biofuels similar to petroleum-based transportation fuels would allow the use of existing engines and infrastructure and would save an enormous amount of capital required for replacing the current infrastructure to accommodate biofuels that have properties significantly different from petroleum-based fuels. Several groups have demonstrated the feasibility of manipulating microbes to produce molecules similar to petroleum-derived products, albeit at relatively low productivity (e.g. maximum butanol production is around 20 g/L). For cost-effective production of biofuels, the fuel-producing hosts and pathways must be engineered and optimized. Advances in metabolic engineering and synthetic biology will ... continued below

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Kuk Lee, Sung; Chou, Howard; Ham, Timothy S.; Soon Lee, Taek & Keasling, Jay D. December 2, 2009.

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This article is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 17 times . More information about this article can be viewed below.

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The ability to generate microorganisms that can produce biofuels similar to petroleum-based transportation fuels would allow the use of existing engines and infrastructure and would save an enormous amount of capital required for replacing the current infrastructure to accommodate biofuels that have properties significantly different from petroleum-based fuels. Several groups have demonstrated the feasibility of manipulating microbes to produce molecules similar to petroleum-derived products, albeit at relatively low productivity (e.g. maximum butanol production is around 20 g/L). For cost-effective production of biofuels, the fuel-producing hosts and pathways must be engineered and optimized. Advances in metabolic engineering and synthetic biology will provide new tools for metabolic engineers to better understand how to rewire the cell in order to create the desired phenotypes for the production of economically viable biofuels.

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  • Journal Name: Current Opinion in Biotechnology; Journal Volume: 19

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  • Report No.: LBNL-3314E
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 983167
  • Archival Resource Key: ark:/67531/metadc1012673

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Office of Scientific & Technical Information Technical Reports

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  • December 2, 2009

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  • Oct. 14, 2017, 8:36 a.m.

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  • Oct. 18, 2017, 10:34 a.m.

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Kuk Lee, Sung; Chou, Howard; Ham, Timothy S.; Soon Lee, Taek & Keasling, Jay D. Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels, article, December 2, 2009; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc1012673/: accessed October 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.