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Tumor production in Syrian hamsters following inhalation of PuO/sub 2/--ZrO/sub 2/ aerosol

Description: Syrian golden hamsters of both sexes were exposed to aerosols of ZrO/sub 2/ containing PuO/sub 2/. The starting material in the aerosol generator also had a small amount of /sup 57/Co added as a tracer. The mixture of all three constituents was nebulized and the droplets passed through a heating column at 1000/sup 0/C. Aerosol sampling was accomplished with a cascade impactor and electrostatic precipitator. The median aerodynamic diameters in all inhalation runs were approximately 2 ..mu..m wit… more
Date: January 1, 1978
Creator: Thomas, R. G. & Smith, D. M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Drug metabolizing enzyme systems and their relationship to toxic mechanisms

Description: The metabolism and toxicity of 3-methylfuran (3-MF) are described. The major product of metabolic activation of 3-MF appears to be disemicarbazones. Cursory description of toxic effects of 3-MF on lung and kidneys are provided. 18 refs.
Date: January 1, 1983
Creator: Boyd, M. R.; Ravindranath, V.; Burka, L. T.; Dutcher, J. S.; Franklin, R. B.; Statham, C. N. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Clonal theory of radiation carcinogenesis

Description: In some cases, usually involving high-LET radiations, the dose response at low doses follows a power function of dose with exponent less than one over a wide dose range. This type of response is of great interest since (a) it implies greater effect per unit dose at progressively smaller doses, and (b) it is not predicted by most models and theories of radiobiology. A theoretical framework is presented for responses having the above characteristics over a dose range extending over a factor of 10… more
Date: January 1, 1982
Creator: Baum, J.W.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Radiation induced micrencephaly in guinea pigs

Description: A brain weight deficit of about 70 mg was induced at doses of approximately 75-mGy and a deficit of 60 mg was induced at 100 mGy. This confirms the effects projected and observed by Wanner and Edwards. Although the data do not demonstrate a clear dose-response relationship between the 75-mGy and 100-mGy groups, the data are statistically consistent with a dose-response effect because of the overlapping confidence intervals. The lack of a statistically significant observation is most likely rela… more
Date: January 1, 1991
Creator: Wagner, L.K.; Johnston, D.A. & Felleman, D.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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DNA repair in spermatocytes and spermatids of the mouse

Description: When male mice are exposed to chemical agents that reach the germ cells several outcomes are possible in terms of the germ cell unscheduled DNA synthesis (UDS) response and removal of DNA adducts. It is possible that: the chemical binds to the DNA and induces a UDS response with concomittant removal of DNA adducts; the chemical binds to the DNA but no UDS response is induced; or the chemical does not bind to DNA and no UDS is induced. Many mutagens have been shown to induce a UDS response in po… more
Date: January 1, 1982
Creator: Sega, G.A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Qualitative analysis of mouse specific-locus mutations: information on genetic organization, gene expression, and the chromosomal nature of induced lesions

Description: Analysis of mouse specific-locus (SL) mutations at three loci has identified over 33 distinct complementation groups - most of which are probably overlapping deficiencies - and 13 to 14 new functional units. The complementation maps that have been generated for the d-se and c regions include numerous vital functions; however, some of the genes in these regions are non-vital. At such loci, hypomorphic mutants must represent intragenic alterations, and some viable nulls could conceivably be intra… more
Date: January 1, 1982
Creator: Russell, L.B.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Dominant lethal study in CD-1 mice following inhalation exposure to 1,3-butadiene: Final technical report

Description: The effects of whole-body inhalation exposures to 1,3-butadiene on the reproductive system was evaluated. The results of dominant lethality in CD-1 male mice that were exposed to 1,3-butadiene are described. Subsequent to exposure, males were mated with two unexposed females. Mating was continued for 8 weeks with replacement of two females each week. Gravid uteri were removed, and the total number, position and status of implantations were determined. The mice were weighed prior to exposure and… more
Date: April 1, 1988
Creator: Hackett, P. L.; Mast, T. J.; Brown, M. G.; Clark, M. L.; Evanoff, J. J.; Rowe, S. E. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Mass and energy budgets of animals: Behavioral and ecological implications

Description: The two major aims of our lab are as follows: First, to develop and field-test general mechanistic models that predict animal life history characteristics as influenced by climate and the physical, physiological behavioral characteristics of species. This involves: understanding how animal time and energy budgets are affected by climate and animal properties; predicting growth and reproductive potential from time and energy budgets; predicting mortality based on climate and time and energy budg… more
Date: November 1, 1991
Creator: Porter, W.P.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Kinetics of reversible-sequestration of leukocytes by the isolated perfused rat lung

Description: The kinetics and morphology of sequestration and margination of rat leukocytes were studied using an isolated perfused and ventilated rat lung preparation. Whole rat blood, bone marrow suspension, or leukocyte suspensions, were used to perfuse the isolated rat lung. The lung was also perfused with latex particle suspensions and the passage of particles through the lung capillaries was studied. When a leukocyte suspension was perfused through the lung in the single-pass mode, the rate of sequest… more
Date: August 1, 1980
Creator: Goliaei, B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Sperm-head morphology study in B6C3F1 mice following inhalation exposure to 1,3-butadiene: Final technical report

Description: The present report describes the results of a study of the morphology of epididymal sperm heads of B6C3F1 mice that were exposed to varying concentrations of 1,3-butadiene. During the fifth post-exposure week, the animals were killed and examined for gross lesions of the reproductive tract; suspensions of the epididymal sperm were prepared for morphologic evaluations. No mortality was observed in any of the inhalation exposure groups. Transient toxic signs, including piloerection and dyspnea, w… more
Date: April 1, 1988
Creator: Hackett, P. L.; McClanahan, B. J.; Brown, M. G.; Buschbom, R. L.; Clark, M. L.; Decker, J. R. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

A toxicological study of gadolinium nitrate

Description: The sensitization study in the guinea pig did not show gadolinium nitrate to have potential sensitizing properties. Skin application studies in the rabbit demonstrated that it was cutaneously a severe irritant. This material was considered an irritant in the rabbit eye application studies. 3 refs., 1 tab.
Date: May 1, 1988
Creator: London, J.E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Radiation dose estimates for copper-64 citrate in man

Description: Tumor imaging agents suitable for use with positron emission tomographs are constantly sought. We have performed studies with animal-tumor-bearing models that have demonstrated the rapid uptake of copper-64. The radiation dose estimates for man indicate that the intravenous administration of 7.0 mCi would result in radiation doses to the kidney of 9.8 to 10.5 rads with other organs receiving substantially less radiation. 5 refs., 3 tabs.
Date: January 1, 1985
Creator: Crook, J.E.; Carlton, J.E.; Stabin, M. & Watson, E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Study of the mechanism of carcinogenesis by carcinogens which are negative in the Ames test. Progress report. [ICE; TUMOR PROMOTERS; PROGESTERONE; QUANTITY RATIO; RATS]

Description: Research progress for 1980 is reported. The role of tRNA methyltransferases in two-1 stage carcinogenesis of mice by phorbol esters has been investigated. The mechanisms of elevation of progesterone levels in the rat by ethionine have also beed studied. (ACR)
Date: unknown
Creator: Borek, E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Low-level x-irradiation of the brain during development morphological, physiological, and behavioral consequences. Final report, September 1, 1976--August 31, 1977

Description: Morphological research was continued in the following areas: glial recovery patterns in the rat corpus callosum after x-irradiation during infancy; the prenatal development of the deep nuclei and cortex of the cerebellum; the prenatal development of the inferior olive, pontine gray and the precerebellar reticular nuclei; and the postnatal development of the olfactory bulb. In these studies autoradiography and x-irradiation were among the experimental techniques utilized. The behavioral studies,… more
Date: January 1, 1977
Creator: Altman, J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Proton microprobe analysis of zinc in skeletal tissues. [Proton induced x-ray emission analysis]

Description: A proton microprobe with windowless exit port was used to study zinc distributions in various types of skeletal tissues. The use of an external beam facilitated positioning of the targets for examination of particular points of interest. The proton microprobe is uniquely suited to this work since it combines high sensitivity for zinc determinations in thick samples with good spatial resolution. Measurements on rat and rabbit Achilles tendon showed a significant increase in zinc concentrations a… more
Date: June 1, 1980
Creator: Doty, S. B.; Jones, K. W.; Kraner, H. W.; Shroy, R. E. & Hanson, A. L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Radiological and Environmental Research Division, Center for Human Radiobiology. Annual report, July 1980-June 1981. [Lead abstract]

Description: Separate abstracts were prepared for the 22 papers of this annual report of the Center for Human Radiobiology. Abstracts were not written for 2 appendices which contain data on the exposure and radium-induced malignancies of 2259 persons whose radium content has been determined at least once. (KRM)
Date: March 1, 1982
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Teratology studies of lewisite and sulfur mustard agents: Effects of lewisite in rats and rabbits: Final report

Description: Lewisite was administered to rats and rabbits by intragastric intubation. Maternal animals were weighed periodically, and, at necropsy (20 dg (days of gestation) in rats and 30 dg in rabbits), were examined for gross lesions of major organs and reproductive performances; live fetuses were weighed and examined for external, internal and skeletal defect. In rats, a dose level of 1.5 mg/kg did not induce toxic or teratogenic responses in maternal and fetal body weights and a significant reduction … more
Date: December 31, 1987
Creator: Hackett, P L; Sasser, L B; Rommereim, R L; Cushing, J A; Buschbom, R L & Kalkwarf, D R
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Evaluation of the mouse micronucleus test as compared with the in vivo cytogenics test for mutagenicity of synthetic fuel materials. Topical report

Description: This brief topical report, provides information on a comparison of the mouse micronucleus mutagenic test proposed by a DOE contractor (FMC) for coal derived chemicals; as compared with the in vivo cytogenic test. The latter procedure is repotedly preferred by EPA authorities connected with implementation of the toxic substances control act (TOSCA). This evaluation was performed at the request of Headquarters DOE program management staff. The mouse micronucleus test takes less time and costs app… more
Date: March 9, 1980
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Particulate oil shale inhalation and pulmonary inflammatory response in rats

Description: This experiment detrimetal that long-term inhalation of shale dusts by rats elicits a limited inflammatory response in the lung less profound than that observed in animals exposed to equivalent levels of quartz alone. This observation suggests that organic and inorganic constituents of shale may provide a protective effect. The implications for fibrogenic disease are two-fold: (1) inhalation of oil shale dusts appeared to be less detriemtal than the inhalation of quartz along, and (2) there was… more
Date: January 1, 1983
Creator: Wilson, J. S.; Holland, L. M.; Halleck, M. S.; Martinez, E. & Saunders, G.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Positron-emitting radioligands for imaging neuroleptic receptors

Description: A series of /sup 18/F-labeled butyrophenones (benperidol, haloperidol, spiroperidol and N-methylspiroperidol) were evaluated in baboons and rats with respect to potential utility as radioligands for studying neuroleptic receptors in the living human brain by positron emission tomography. These compounds were administered to baboons, and the radioactivity distributions to the striatum, and to the cerebellum were determined by PET at times up to 8 hours after isotope injection. 4 refs. (DT)
Date: January 1, 1985
Creator: Arnett, C. D.; Fowler, J. S.; Wolf, A. P.; Shiue, C. Y. & Logan, J.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Studies defining interactions between hypertension and air pollutants

Description: An animal model of hypertension was developed by breeding two lines of rats. The model was used to investigate interactions between commonly encountered air pollutants and the development of hypertension. This paper summarizes studies of the interaction of sulfur dioxide and ozone with the models. (ACR)
Date: January 1, 1980
Creator: Drew, R T; Costa, D L; Haber, S & Iwai, J
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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