3,4,3-LI(1,2-HOPO): In Vitro Formation of Highly Stable Lanthanide Complexes Translates into Efficacious In Vivo Europium Decorporation Metadata

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Title

  • Main Title 3,4,3-LI(1,2-HOPO): In Vitro Formation of Highly Stable Lanthanide Complexes Translates into Efficacious In Vivo Europium Decorporation

Creator

  • Author: Sturzbecher-Hoehne, Manuel
    Creator Type: Personal
  • Author: Ng Pak Leung, Clara
    Creator Type: Personal
  • Author: Daleo, Anthony
    Creator Type: Personal
  • Author: Kullgren, Birgitta
    Creator Type: Personal
  • Author: Prigent, Anne-Laure
    Creator Type: Personal
  • Author: Shuh, David K.
    Creator Type: Personal
  • Author: Raymond, Kenneth N.
    Creator Type: Personal
  • Author: Abergel, Rebecca J.
    Creator Type: Personal

Contributor

  • Sponsor: United States. Department of Energy. Office of Basic Energy Sciences.
    Contributor Type: Organization
    Contributor Info: Chemical Sciences Division

Publisher

  • Name: Lawrence Berkeley National Laboratory
    Place of Publication: Berkeley, California
    Additional Info: Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (United States)

Date

  • Creation: 2011-07-13

Language

  • English

Description

  • Content Description: The spermine-based hydroxypyridonate octadentate chelator 3,4,3-LI(1,2-HOPO) was investigated for its ability to act as an antennae that sensitizes the emission of Sm{sup III}, Eu{sup III}, and Tb{sup III} in the Visible range (Φ{sub tot} = 0.2 - 7%) and the emission of Pr{sup III}, Nd{sup III}, Sm{sup III}, and Yb{sup III} in the Near Infra-Red range, with decay times varying from 1.78 μs to 805 μs at room temperature. The particular luminescence spectroscopic properties of these lanthanide complexes formed with 3,4,3-LI(1,2-HOPO) were used to characterize their respective solution thermodynamic stabilities as well as those of the corresponding La{sup III}, Gd{sup III}, Dy{sup III}, Ho{sup III}, Er{sup III}, Tm{sup III}, and Lu{sup III} complexes. The remarkably high affinity of 3,4,3-LI(1,2-HOPO) for lanthanide metal ions and the resulting high complex stabilities (pM values ranging from 17.2 for La{sup III} to 23.1 for Yb{sup III}) constitute a necessary but not sufficient criteria to consider this octadentate ligand an optimal candidate for in vivo metal decorporation. The in vivo lanthanide complex stability and decorporation capacity of the ligand were assessed, using the radioactive isotope {sup 152}Eu as a tracer in a rodent model, which provided a direct comparison with the in vitro thermodynamic results and demonstrated the great potential of 3,4,3-LI(1,2-HOPO) as a therapeutic metal chelating agent.
  • Physical Description: 8340

Subject

  • STI Subject Categories: 37 Inorganic, Organic, Physical, And Analytical Chemistry
  • STI Subject Categories: 60 Applied Life Sciences
  • STI Subject Categories: 59 Basic Biological Sciences

Source

  • Journal Name: Dalton Transactions; Journal Volume: 40; Journal Issue: 33

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Article

Format

  • Text

Identifier

  • Report No.: LBNL-5195E
  • Grant Number: DE-AC02-05CH11231
  • DOI: 10.1039/c1dt10840a
  • Office of Scientific & Technical Information Report Number: 1051843
  • Archival Resource Key: ark:/67531/metadc827667
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