title: 3,4,3-LI(1,2-HOPO): In Vitro Formation of Highly Stable Lanthanide
 Complexes Translates into Efficacious In Vivo Europium Decorporation
creator: Sturzbecher-Hoehne, Manuel
creator: Ng Pak Leung, Clara
creator: Daleo, Anthony
creator: Kullgren, Birgitta
creator: Prigent, Anne-Laure
creator: Shuh, David K.
creator: Raymond, Kenneth N.
creator: Abergel, Rebecca J.
contributor: United States. Department of Energy. Office of Basic Energy
 Sciences.
publisher: Lawrence Berkeley National Laboratory
date: 2011-07-13
language: English
description: The spermine-based hydroxypyridonate octadentate chelator
 3,4,3-LI(1,2-HOPO) was investigated for its ability to act as an antennae that
 sensitizes the emission of Sm{sup III}, Eu{sup III}, and Tb{sup III} in the
 Visible range (Φ{sub tot} = 0.2 - 7%) and the emission of Pr{sup III}, Nd{sup
 III}, Sm{sup III}, and Yb{sup III} in the Near Infra-Red range, with decay
 times varying from 1.78 μs to 805 μs at room temperature. The particular
 luminescence spectroscopic properties of these lanthanide complexes formed
 with 3,4,3-LI(1,2-HOPO) were used to characterize their respective solution
 thermodynamic stabilities as well as those of the corresponding La{sup III},
 Gd{sup III}, Dy{sup III}, Ho{sup III}, Er{sup III}, Tm{sup III}, and Lu{sup
 III} complexes. The remarkably high affinity of 3,4,3-LI(1,2-HOPO) for
 lanthanide metal ions and the resulting high complex stabilities (pM values
 ranging from 17.2 for La{sup III} to 23.1 for Yb{sup III}) constitute a
 necessary but not sufficient criteria to consider this octadentate ligand an
 optimal candidate for in vivo metal decorporation. The in vivo lanthanide
 complex stability and decorporation capacity of the ligand were assessed,
 using the radioactive isotope {sup 152}Eu as a tracer in a rodent model, which
 provided a direct comparison with the in vitro thermodynamic results and
 demonstrated the great potential of 3,4,3-LI(1,2-HOPO) as a therapeutic metal
 chelating agent.
subject: 37 Inorganic, Organic, Physical, And Analytical Chemistry
subject: 60 Applied Life Sciences
subject: 59 Basic Biological Sciences
source: Journal Name: Dalton Transactions; Journal Volume: 40; Journal Issue: 33
type: Article
format: 8340
format: Text
identifier: rep-no: LBNL-5195E
identifier: grantno: DE-AC02-05CH11231
identifier: doi: 10.1039/c1dt10840a
identifier: osti: 1051843
identifier: https://digital.library.unt.edu/ark:/67531/metadc827667/
identifier: ark: ark:/67531/metadc827667