Determination of Solute Descriptors for Illicit Drugs Using Gas Chromatographic Retention Data and Abraham Solvation Model Page: 15
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Table 1.4. Stationary phase interactions.
Functional Dispersion Dipole Hydrogen
group bonding
Methyl strong none none
Phenyl strong none to weak weak
Cyanopropyl strong very strong moderate
Trifluoropropyl strong moderate weak
PEG strong strong moderate
Table 1.4 shows the dispersion, dipole and hydrogen bonding of different functional
group for the stationary phase interactions [47].
1.3.5 Inlet System
The amount of analyte to be injected to the column must be controlled so that the inlet
system does not deliver a huge amount of sample to the column. The sample must be vaporized
prior to get into the column. The injector should not be too hot; otherwise the sample will be
decomposed. The set of temperature is 50 C above the boiling of the highest boiling sample.
The peak shape will be poor if the temperature is too low. The inlet system has a microsyringe
through which the simple is introduce to the inlet port. The syringe must be a gas-tight type to
avoid loss of sample. Inside the inlet, there is an inlet liner that provides proper mixing of sample
vapor with carrier gas and prevents non-volatile material to get in contact with the column.
There are two types of injection system.
1 split/splitless
2 On column
1.3.5.1 Split/Splitless
In split/splitless mode the sample is injected after mixing with the carrier gas, then it
splits into two unequal portions. One part goes to the column; the other portion goes to waste.
The disadvantage of split mode is that the rest of sample that did not go to the column is wasted.
With the splitless option, the whole amount of sample is injected through the column. The15
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Mitheo, Yannick K. Determination of Solute Descriptors for Illicit Drugs Using Gas Chromatographic Retention Data and Abraham Solvation Model, thesis, August 2015; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc804935/m1/24/?rotate=90: accessed July 17, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .