Medical and Health Divisions quarterly report, July, August, September, 1948 Page: 6 of 59
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UCRL 193
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Tracer Studies
Actinium0 Intramuscular studies in rats with Ac have been completed up to 256
days after administration. At this time period, 5 percent remained at the site of
injection. The major part of the activity absorbed was eliminated in the urine and
feces. The balance of the retained activity was primarily found in the skeletal
system, the skin, and in the liver. The average values of the actinium deposition
in the other tissues are to be found in Table I.
Arsenic. The deposition of carrier-free As74 has been completed up to 32 days.
These values are similar to those reported earlier with the exception of more
uniformity among the observations. As was reported earlier, the major part of
the arsenic is included within the red blood cells. The relative deposition of
arsenic in blood as well as the other tissues is summarized in Table II. In
addition to the above studies, carrier-arsenic as inactive arsenic was added to
the carrier-free material in concentrations of .01, 01, and 1.0 mg, being ad-
ministered to rats by intramuscular injection. As increasing amounts of carrier
were added, a slight drop in the ability of the red blood cells to combine with
the arsenic administered was observed, although the effect was not large. In
addition to this, the fecal excretion rose at the expense of the urinary excre-
tion. These data are summarized in Table III. The site of deposition of arsenic
in the. red blood cells has been investigated. The major part of the arsenic is
combined with the globin fraction of the hemoglobin.of the red cell and this
increases with the addition of arsenic carrier. These studies are being continued
ih order to determine if the same situation exists in the human as in the rat,
since this method of labeling a red cell when combined with the radioautographic
technique should enable one to determine the life of the red cell in the body in
normal and abnormal conditions.
Columbium. A series of rat-s have been studied after the intramuscular injection
of carrier-free Cb95 which has been complexed with sodium citrate. One, four and
sixteen day animals received 1.5 mg. sodium citrate with the activity. The 32
and 64 day animals received 3. mg. sodium citrate. When columbium is complexed
in this manner, it is relatively easily absorbed from the injection site, since at
1 day following administration, 33 percent remained. This value dropped to 18.9
percent at 4 days, 8 percent at 16 days, 6 percent at 32 days, and 4.2 percent at
64 days. After absorption of Cb95, the major amount 6f the activity remaining in
the animal is deposited in the skeleton, with measurable amounts present in the
liver and blood at 1 and 4 days after administration. Later time periods show
rather high skeleton, liver, and kidney values, but relatively lower blood values.
Columbium is excreted almost equally by both the urine and feces. This data can
be seen in Table IV. In addition to the above studies, columbium was also complexed
with oxalate. As with the citrate, this material also enhances absorption from
the injection site. Data showing these results are to be found in Table V.
Zuropium. Europium with carrier has been ecinpleted to 32 days following intramus-
cular administration. This member of the lanthanide series of rare earths is
absorbed from the injection site with difficulty. Sixty-four, sixty-three, fifty-
eight, and fifty-three percent of the administered material remained at the
injection site 1, 4, 16, and 32 days respectively. of the material absorbed, the
major regions of deposition were the skeleton, liver, kiney, and skin. The
material found in the soft tissues is apparntly gradually eliminated in the urine
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Medical and Health Divisions quarterly report, July, August, September, 1948, report, November 1, 1995; Berkeley, California. (https://digital.library.unt.edu/ark:/67531/metadc624130/m1/6/: accessed May 5, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.