Chemical Information Bulletin, Volume 43, Number 1, Spring 1991 Page: 30
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agencies have produced fact sheets, books, and
tapes, etc., concerned with environmental health.
Examples of these resources will be on display.
The speaker will also provide packets of information
on all resources discussed.
11:30 AM
27. THE VALUE OF ADEQUATE DATA DOCUMENTATION
IN HEALTH AND ENVIRONMENT SCIENCES.
Curtis Elmer, Monsanto Company,
800 N. Lindbergh, St. Louis, MO 63167, and
Sidney Siegel, National Library of Medicine,
Bldg. 38A - Room 4S-404, 8600 Rockville
Pike, Bethesda, MD 20894.
Contrary to most other scientific disciplines, studies
performed in Health and Environmental Sciences
are frequently difficult to replicate or even
compare. The subjects or conditions under study
are usually unique with respect to the time and/or
conditions when the study is performed. Therefore,
detailed documentation of the particular material,
subjects and/or environment being evaluated
must be considered by the user of resulting data
in order to judge its suitability for aggregating,
comparing and/or extrapolating to support decision
making. The rapidly expanding literature database
coupled with greater demand for its use in making
hazard/risk assessments justifies an effort to annotate
references as to the completeness of data
documentation so that potential users can know
what to expect from a wide variety of data
sources. A project which, for the past six years,
has attempted to establish the feasibility of assigning
Data Documentation Completeness Indicators
will be discussed.
1:30 PM
28. SEARCHING TOXICOLOGY INFORMATION IN
AN ONLINE SYSTEM. Dr. Sujit J. Chatterji
and Dr. Hedy A. Mulhausen, Chemical Abstracts
Service, 2540 Olentangy River Road,
P.O. Box 3012, Columbus, OH 43210.
Toxicology information on chemical substances is
available online in many multidisciplinary files,
such as BIOSIS, CA, MEDLINE, JICST-E and NTIS.
More recently, there are many other databases that
focus specifically on numeric property data, some
of which are needed for Material Safety Data
Sheets (MSDS) and other plant safety needs; such
chemical and physical property data can be found
in databases such as BEILSTEIN, DIPPR, HODOC,
JANAF, and TRCHTHERMO. Calculations of temperature-dependent
properties, such as vapor pressure can also be performed in the DIPPR file.
Most toxicologists are also involved in monitoring
the Environmental Protection Agency regulations.There are specialized databases that cover this
type of information, such as CHEMLIST. This is a
database produced by the American Petroleum Institute
that covers virtually all pertinent regulatory
information published in the Federal Register,
TSCA Unpublished Test Submissions (TSCATS),
and other sources. An overview of searching thee
databases and others on STN International to maximize
retrieval of toxicology information will be
presented.
2:00 PM
29. TOXICOLOGY INFORMATION - PHARMACEUTICAL
PERSPECTIVE. Susan A. McKee, Burroughs
Wellcome Co., 3030 Cornwallis Rd.,
RTP, NC 27709.
New drug development requires extensive toxicity
testing to provide evidence of safety of new chemical
entities and their pharmaceutical formulations.
The experimental design of these toxicity studies
is established based on reviews of the published
literature for similar types of studies. Literature
searches are also conducted to find information on
diagnostic and animal handling procedures; reference
ranges for normal values; animal disease
models; and toxicity of potential contaminants, metabolites
and breakdown products. Searches for
information on chemicals start in databases of
chemical substances such as Chemical Abstracts
Service's Registry file and National Library of
Medicine's ChemlD file. Each of these databases
contains "locator codes" that lead the searcher to
factual or bibliographic databases containing information
about these substances. Toxline, Chemical
Abstracts, Registry of Toxic Effects of Chemical
Substances and Hazardous Substances Data Bank
are among the primary online sources of toxicology
information. These sources will be discussed
as will as some less familiar ones provided by a
variety of online vendors.
2:30 PM
30. CHEMICAL COMPANY PERSPECTIVE ON
REGULATORY INFORMATION RESOURCES.
Lynda M. Wiseman, Hoechst Celanese Corporation,
Rts. 202-206, Somerville, NJ 088761258.Corporate managers of occupational health and
safety monitor and analyze new regulatory initiatives,
prepare written comments on proposed regulations,
and develop corporate wide policies and
guidelines. They are often called on to interpret
existing regulations. This presentation will describe the resources (printed sources, online vendors
and diskette services) a chemical company
manager utilizes to track new regulations and de30 CHEMICAL INFORMATION BULLETIN
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American Chemical Society. Division of Chemical Information. Chemical Information Bulletin, Volume 43, Number 1, Spring 1991, periodical, Spring 1991; Philadelphia, Pennsylvania. (https://digital.library.unt.edu/ark:/67531/metadc5654/m1/32/: accessed May 8, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .