A preliminary study of the effects of selective-serotonin re-uptake inhibitors (SSRIs) on central auditory processing

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his study compared auditory behavioral and physiological measures among three subject groups: 1) Normal control subjects, 2) subjects who were on a prescribed SSRI for depression, and 3) subjects who were prescribed an SSRI for depression, but were not medicated at the time of testing. Test measures included: Standard audiological tests (audiometry and tympanometry), electrophysiological procedures for analysis of auditory- evoked brainstem and late responses, and standardized behavioral speech tests (SCAN-A, SSI, and the low predictability sentence list of the R-SPIN). Analysis of results indicated a statistically significant increase of group mean amplitude of the ABR peak V, from 15dBnSL … continued below

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Bishop, Charles E. August 2001.

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  • Bishop Charles E.

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his study compared auditory behavioral and physiological measures among three subject groups: 1) Normal control subjects, 2) subjects who were on a prescribed SSRI for depression, and 3) subjects who were prescribed an SSRI for depression, but were not medicated at the time of testing. Test measures included: Standard audiological tests (audiometry and tympanometry), electrophysiological procedures for analysis of auditory- evoked brainstem and late responses, and standardized behavioral speech tests (SCAN-A, SSI, and the low predictability sentence list of the R-SPIN). Analysis of results indicated a statistically significant increase of group mean amplitude of the ABR peak V, from 15dBnSL to 55dBnSL, in the non-medicated group compared to controls.
Also, the non-medicated group scored significantly less favorably than controls on the most challenging listening condition (-20 MCR) of the SSI, in the left ear. Although other test measures indicated consistent differences between these two groups, they were not, however, significant.

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  • August 2001

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  • Sept. 25, 2007, 10:20 p.m.

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  • April 6, 2020, 7:50 p.m.

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Bishop, Charles E. A preliminary study of the effects of selective-serotonin re-uptake inhibitors (SSRIs) on central auditory processing, thesis, August 2001; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc2853/: accessed June 29, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .

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