Investigating the Effects of Traffic-Generated Air-Pollution on the Microbiome and Immune Responses in Lungs of Wildtype Mice Page: 80
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due to respiratory infection deaths (WHO Global Health Observatory data, 2016). There are close
to 380 million people living with COPD and it is expected to become the leading cause of death
in 15 years (Quaderi and Hurst, 2018). Understanding the lung microbiota shifts in response to the
environment and diet to be a possible contributor in the development and worsening of lung
diseases is paramount to identifying the mechanistic pathways involved in air-pollutant mediated
effects on lung diseases and overall health.
3.7 Conflict of Interest
Probiotics were provided by Winclove Probiotics and funding from a grant received from
the National Institute of Environmental Health Sciences at National Institute of Health was used
to conduct some of the studies described, herein; however, the authors declare no conflict of
interest or financial gains to these entities associated with this publication.
3.8 Funding
This work was supported by National Institute of Environmental Health Sciences at the
National Institute of Health [R15ES026795] and internal funding from the University of North
Texas.
3.9 Acknowledgements
The authors would like to thank Dr. Saskia vanHemert and Jojanneke Schmidt, at Winclove
Probiotics, for their assistance in providing the Ecologic Barrier Probiotics for this study.
Additionally, we would like to thank Dr. Usa Suwannasual, JoAnn Lucero, Tyler Armstrong, and
Nicholas Mitchell for their assistance with animal exposures, as well as Dr. Imelda Norton from
UNT Vivarium for her assistance in the monitoring of the animals throughout the study duration.
We thank Dr. Art Goven for his guidance and assistance in the blood differential assessments.80
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Daniel, Sarah. Investigating the Effects of Traffic-Generated Air-Pollution on the Microbiome and Immune Responses in Lungs of Wildtype Mice, dissertation, December 2020; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc1752346/m1/92/?q=j+w+gardner: accessed July 6, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .