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Independence of Mania and Depression across 4 Years in Bipolar Disorder

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If mania and depression are part of the same pathological processes, one would predict that episodes of one prospectively increase the odds of episodes of the other. The aim of the present study was to test this hypothesis. For comparison purposes, their relationship was contrasted to the relationship between mania and periods of psychosis. Exploratory analyses also tested the degree to which episodes of each occur with greater frequency over time (i.e., kindling). Participants for the present study came from the Suffolk County Mental Health Project (N = 628), a study of first-admission patients with psychosis. Of these participants, 144 … continued below

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v, 44 pages

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Bennett, Charles B. May 2019.

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This thesis is part of the collection entitled: UNT Theses and Dissertations and was provided by the UNT Libraries to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 80 times. More information about this thesis can be viewed below.

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  • Bennett, Charles B

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If mania and depression are part of the same pathological processes, one would predict that episodes of one prospectively increase the odds of episodes of the other. The aim of the present study was to test this hypothesis. For comparison purposes, their relationship was contrasted to the relationship between mania and periods of psychosis. Exploratory analyses also tested the degree to which episodes of each occur with greater frequency over time (i.e., kindling). Participants for the present study came from the Suffolk County Mental Health Project (N = 628), a study of first-admission patients with psychosis. Of these participants, 144 met diagnostic criteria for bipolar I disorder and were analyzed for the current study. Results indicated that mania in a given month predicted depression the following month, even after controlling for other symptoms. The reverse, however, was not the case. Mania and psychosis, in contrast, were found to be robust predictors of one another from month to month. Effects were not due to treatment or demographic differences. These findings provide evidence that mania and depression are weakly related. In contrast, mania and psychosis are more closely linked. Findings are consistent with suggestions that psychiatric nosology regroup mania more closely with thought disorders rather than with internalizing or depressive ones. They also alert clinicians to the strong, longitudinal persistence and comorbidity among these syndromes.

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v, 44 pages

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  • May 2019

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  • June 9, 2019, 9:09 p.m.

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  • July 8, 2021, 4:59 p.m.

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Thumbnail image of item number 1 in: 'Independence of Mania and Depression across 4 Years in Bipolar Disorder'.
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Thumbnail image of item number 4 in: 'Independence of Mania and Depression across 4 Years in Bipolar Disorder'.

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Bennett, Charles B. Independence of Mania and Depression across 4 Years in Bipolar Disorder, thesis, May 2019; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc1505184/: accessed May 23, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .

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