Kinetic and biochemical studies on tumor growth. Final report, October 1, 1967--July 14, 1976. [X radiation, /sup 125/I tracer technique]

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The normal growth kinetics and the recovery kinetics following therapeutic perturbations with drugs and x-irradiation for the mouse duodenal crypt cells and the S102F and slow line tumor cells have been studied in depth, the rationale being that a detailed understanding of these phenomena would enhance our knowledge about tumor biology per se and also expand our appreciation of how normal and malignant tissues respond to and recover from therapeutic insults. Hopefully, such knowledge will eventually allow one to design logical, optimal protocols for cancer therapy. During the course of this contract, a new direct method (The /sup 125/I-IUdR Method) … continued below

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10 pages

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Dethlefsen, L. A. Creation Date: Unknown.

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The normal growth kinetics and the recovery kinetics following therapeutic perturbations with drugs and x-irradiation for the mouse duodenal crypt cells and the S102F and slow line tumor cells have been studied in depth, the rationale being that a detailed understanding of these phenomena would enhance our knowledge about tumor biology per se and also expand our appreciation of how normal and malignant tissues respond to and recover from therapeutic insults. Hopefully, such knowledge will eventually allow one to design logical, optimal protocols for cancer therapy. During the course of this contract, a new direct method (The /sup 125/I-IUdR Method) for measuring cell loss from solid tumors in vivo was developed. Also it was established that the new flow cytometry methodology would be very useful for studying the normal and perturbed kinetics of solid tumors. The extensive hydroxyurea data as well as the preliminary adriamycin and x-irradiation data which have been collected on the recovery kinetics of the duodenum and mammary tumors have advanced our awareness of the complexity of these phenomena and how different the effects are when different drugs are used either alone or in conjunction with x-irradiation.

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  • Report No.: COO-2269-11
  • Grant Number: AT(11-1)-2269
  • Office of Scientific & Technical Information Report Number: 7351024
  • Archival Resource Key: ark:/67531/metadc1446891

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Thumbnail image of item number 1 in: 'Kinetic and biochemical studies on tumor growth. Final report, October 1, 1967--July 14, 1976. [X radiation, /sup 125/I tracer technique]'.
Thumbnail image of item number 2 in: 'Kinetic and biochemical studies on tumor growth. Final report, October 1, 1967--July 14, 1976. [X radiation, /sup 125/I tracer technique]'.
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Dethlefsen, L. A. Kinetic and biochemical studies on tumor growth. Final report, October 1, 1967--July 14, 1976. [X radiation, /sup 125/I tracer technique], report, Date Unknown; United States. (https://digital.library.unt.edu/ark:/67531/metadc1446891/: accessed July 16, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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