Development of positron emitting radionuclides for imaging with improved positron detectors. [/sup 82/Rb, /sup 62/Zn, /sup 64/Cu, /sup 67/Ga]
Description
Recent advances in positron cameras and positron ring detectors for transverse section reconstruction have created renewed interest in positron emitting radionuclides. This paper reports on: generator-produced /sup 82/Rb; cyclotron-produced /sup 62/Zn; and reactor-produced /sup 64/Cu. Investigation of the /sup 82/Sr (25 d)--/sup 82/Rb (75 s) generator determined the elution characteristics for Bio-Rex 70, a weakly acidic carboxylic cation exchanger, using 2% NaCl as the eluent. The yield of /sup 82/Rb and the breakthrough of /sup 82/Sr were determined for newly prepared columns and for long term elution conditions. Spallation-produced /sup 82/Sr was used to charge a compact /sup 82/Rb generator … continued below
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22 pages
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Yano, Y. October 1, 1976.
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Lawrence Berkeley Laboratory
Publisher Info: California Univ., Berkeley (USA). Lawrence Berkeley Lab.Place of Publication: Berkeley, California
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Description
Recent advances in positron cameras and positron ring detectors for transverse section reconstruction have created renewed interest in positron emitting radionuclides. This paper reports on: generator-produced /sup 82/Rb; cyclotron-produced /sup 62/Zn; and reactor-produced /sup 64/Cu. Investigation of the /sup 82/Sr (25 d)--/sup 82/Rb (75 s) generator determined the elution characteristics for Bio-Rex 70, a weakly acidic carboxylic cation exchanger, using 2% NaCl as the eluent. The yield of /sup 82/Rb and the breakthrough of /sup 82/Sr were determined for newly prepared columns and for long term elution conditions. Spallation-produced /sup 82/Sr was used to charge a compact /sup 82/Rb generator to obtain multi-millicurie amounts of /sup 82/Rb for myocardial imaging. Zinc accumulates in the islet cells of the pancreas and in the prostate. Zinc-62 was produced by protons on Cu foil and separated by column chromatography. Zinc-62 was administered as the amino acid chelates and as the ZnCl/sub 2/ to tumor and normal animals. Tissue distribution was determined for various times after intravenous injection. Pancreas-liver images of /sup 62/Zn-histidine uptake were obtained in animals with the gamma camera and the liver uptake of /sup 99m/Tc sulfur colloid was computer subtracted to image the pancreas alone. The positron camera imaged uptake of /sup 62/Zn-histidine in the prostate of a dog at 20 h. /sup 64/Cu was chelated to asparagine, a requirement of leukemic cells, and administered to lymphoma mice. Uptake in tumor and various tissues was determined and compared with the uptake of /sup 67/Ga citrate under the same conditions. /sup 64/Cu-asparagine had better tumor-to-soft tissue ratios than /sup 67/Ga-citrate.
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22 pages
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Keywords
- Alkali Metal Isotopes
- Alkaline Earth Isotopes
- Animals
- Beta Decay Radioisotopes
- Beta-Minus Decay Radioisotopes
- Beta-Plus Decay Radioisotopes
- Body
- Cameras
- Cardiovascular System
- Colloids
- Copper 64
- Copper Isotopes
- Counting Techniques
- Days Living Radioisotopes
- Diagnostic Techniques
- Digestive System
- Diseases
- Dispersions
- Electron Capture Radioisotopes
- Elements
- Endocrine Glands
- Even-Even Nuclei
- Gallium
- Gamma Cameras
- Glands
- Heart
- Hours Living Radioisotopes
- Intermediate Mass Nuclei
- Isomeric Nuclei
- Isomeric Transition Isotopes
- Isotopes
- Lymphomas
- Male Genitals
- Mammals
- Metals
- Mice
- Minutes Living Radioisotopes
- Muscles
- Myocardium
- Neoplasms
- Nuclear Reactions
- Nuclei
- Odd-Even Nuclei
- Odd-Odd Nuclei
- Organs
- Pancreas
- Positron Cameras
- Prostate
- Radiocolloids
- Radioisotope Generators
- Radioisotope Scanning
- Radioisotopes
- Rodents
- Rubidium 82
- Rubidium Isotopes
- Scintiscanning
- Spallation
- Strontium 82
- Strontium Isotopes
- Technetium 99
- Technetium Isotopes
- Vertebrates
- Years Living Radioisotopes
- Zinc 62
- Zinc Isotopes 550601* -- Medicine-- Unsealed Radionuclides In Diagnostics
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- IAEA symposium on medical radionuclide imaging, Los Angeles, CA, USA, 25 Oct 1976
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- Report No.: LBL-4785
- Report No.: CONF-761060-7
- Report No.: IAEA-SM-210/123
- Grant Number: W-7405-ENG-48
- Office of Scientific & Technical Information Report Number: 7124666
- Archival Resource Key: ark:/67531/metadc1412878
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- October 1, 1976
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- Jan. 23, 2019, 12:54 p.m.
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Yano, Y. Development of positron emitting radionuclides for imaging with improved positron detectors. [/sup 82/Rb, /sup 62/Zn, /sup 64/Cu, /sup 67/Ga], article, October 1, 1976; Berkeley, California. (https://digital.library.unt.edu/ark:/67531/metadc1412878/: accessed July 16, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.