Radioactive Isotopes - Metabolic, Diagnostic and Therapeutic Uses Page: 2
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2.
in cellular function, temporary or permanent, and in a special
category, injury associated with mitotic activity which may be
inheritable. The different tissues vary markedly in their radio-
sensitivity or response to this type of energy applied to the
cell system or its constituents.
Information regarding the biological effects of radiation
produced by radioactive isotopes has accumulated in time coming
from many sources (8-10). Extrapolation of information derived
in animal investigation to reactions and effects in man is subject
to hazard. Increased accumulated human knowledge and experience
can be achieved in the aged. Because effects of radiation require
time to appear and because these delayed effects may be undesirable
while the immediate effects may be desirable, radioactive isotopes
orovide a unique opportunity to develop better control of disease
in the older individual (11) •
In a consideration of the employment of radioactive
isotopes, it is first necessary to clearly establish that as a
drug class, radioactive isotopes are not a unified category of
drugs but possess an additional unique property. This property
may be constructed into any type of molecule. Ridioactive isotopes
are particularly useful for obtaining dynamic, distribution,
metabolic and ultimate fate information of a molecule or drug.
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Farr, Lee E, M. D. & Easterday, O. D., Ph. D. Radioactive Isotopes - Metabolic, Diagnostic and Therapeutic Uses, report, April 23, 1962; Upton, New York. (https://digital.library.unt.edu/ark:/67531/metadc1201066/m1/3/?q=j+w+gardner: accessed June 22, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.