Nuclear medicine technology. Progress report, quarter ending March 31, 1980
Description
The successful detection of experimentally produced myocardial infarctions in rats and dogs using /sup 123m/Te-9-telluraheptadecanoic acid (9-(/sup 123m/Te)-THDA) is described. Preferential localization of radioactivity in normal myocardial tissue of rats that had experimentally produced infarctions was also demonstrated by tissue distribution studies following injection of 9-(/sup 123m/Te)-THDA. The effects of chain length on the myocardial uptake of /sup 75/Se-labeled long-chain fatty acids was also studied further. Selenium-75-labeled 13-selenaheneicosonic acid (H/sub 3/C-(CH/sub 2/)/sub 7/-/sup 75/Se-(CH/sub 2/)/sub 11/-COOH, 13-(/sup 75/Se)-SHCA) shows the highest heart uptake in rats of the agents studied. These results indicate that myocardial imaging may be possible with 13-(/sup … continued below
Physical Description
25 pages
Creation Information
Knapp, F. F. Jr. October 1, 1980.
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Oak Ridge National Laboratory
Publisher Info: Oak Ridge National Lab., TN (USA)Place of Publication: Tennessee
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Description
The successful detection of experimentally produced myocardial infarctions in rats and dogs using /sup 123m/Te-9-telluraheptadecanoic acid (9-(/sup 123m/Te)-THDA) is described. Preferential localization of radioactivity in normal myocardial tissue of rats that had experimentally produced infarctions was also demonstrated by tissue distribution studies following injection of 9-(/sup 123m/Te)-THDA. The effects of chain length on the myocardial uptake of /sup 75/Se-labeled long-chain fatty acids was also studied further. Selenium-75-labeled 13-selenaheneicosonic acid (H/sub 3/C-(CH/sub 2/)/sub 7/-/sup 75/Se-(CH/sub 2/)/sub 11/-COOH, 13-(/sup 75/Se)-SHCA) shows the highest heart uptake in rats of the agents studied. These results indicate that myocardial imaging may be possible with 13-(/sup 75/Se)-SHCA and also suggest that potential positron emission tomography of the myocardium with the /sup 73/Se-labeled agent should be explored. The results of continuing studies with /sup 11/C and /sup 195m/Pt-labeled agents are also described. A variety of /sup 11/C-labeled amino acids were prepared and tested as pancreas and tumor localizing agents in a Medical Cooperative Program with the Oak Ridge Associated Universities. The microscale synthesis of /sup 195m/Pt-labeled cis-dichloro-trans-dihydroxy-bis-(isopropylamine)platinum(IV) (/sup 195m/Pt-CHIP) was developed further and preliminary tissue distribution studies with this important second-generation antitumor drug were completed in rats. Platinum-195m-labeled cis-dichlorodiammineplatinum(II) (/sup 195m/Pt-cis-DDP) was supplied for testing to a number of Medical Cooperative Programs. Studies of arsenic trioxide (As/sub 2/O/sub 3/) toxicity for human cells in the diffusion chamber assay system have continued. Further investigation of this arsenic-induced cytotoxicity has demonstrated a linear dose-response relationship and a difference in the permanence of the growth inhibitory effect using different doses.
Physical Description
25 pages
Notes
NTIS, PC A02/MF A01.
Subjects
Keywords
- Amino Acids
- Animal Cells
- Animals
- Antineoplastic Drugs
- Arsenic Compounds
- Arsenic Oxides
- Beta Decay Radioisotopes
- Beta-Plus Decay Radioisotopes
- Biological Effects
- Biological Localization
- Body
- Carbon 11
- Carbon Isotopes
- Carboxylic Acid Esters
- Carboxylic Acids
- Cardiovascular Diseases
- Cardiovascular System
- Cell Proliferation
- Chalcogenides
- Chemical Preparation
- Complexes
- Computerized Tomography
- Counting Techniques
- Days Living Radioisotopes
- Diagnosis
- Diagnostic Techniques
- Digestive System
- Diseases
- Distribution
- Dose-Response Relationships
- Drugs
- Electron Capture Radioisotopes
- Emission Computed Tomography
- Endocrine Glands
- Esters
- Even-Odd Nuclei
- Feasibility Studies
- Glands
- Heart
- Heavy Nuclei
- Intermediate Mass Nuclei
- Internal Conversion Radioisotopes
- Isomeric Transition Isotopes
- Isotopes
- Labelled Compounds
- Light Nuclei
- Mammals
- Materials
- Minutes Living Radioisotopes
- Muscles
- Myocardial Infarction
- Myocardium
- Neoplasms
- Nuclei
- Organic Acids
- Organic Chlorine Compounds
- Organic Compounds
- Organic Halogen Compounds
- Organs
- Oxides
- Oxygen Compounds
- Pancreas
- Platinum 195
- Platinum Complexes
- Platinum Isotopes
- Positron Computed Tomography
- Primates
- Radioactive Materials
- Radioisotope Scanning
- Radioisotopes
- Radionuclide Kinetics
- Radiopharmaceuticals
- Rats
- Rodents
- Scintiscanning
- Selenium 75
- Selenium Compounds
- Selenium Isotopes
- Stable Isotopes
- Synthesis
- Tellurium 123
- Tellurium Compounds
- Tellurium Isotopes
- Tissue Distribution
- Tomography
- Toxicity
- Transition Element Complexes
- Vertebrates 550601* -- Medicine-- Unsealed Radionuclides In Diagnostics
STI Subject Categories
- 38 Radiation Chemistry, Radiochemistry, And Nuclear Chemistry
- 400702 -- Radiochemistry & Nuclear Chemistry-- Properties Of Radioactive Materials
- 560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
- 560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
- 560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
- 62 Radiology And Nuclear Medicine
- 63 Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat.
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- Report No.: ORNL/TM-7411
- Grant Number: W-7405-ENG-26
- Digital Object Identifier: https://doi.org/10.2172/6773915
- Office of Scientific & Technical Information Report Number: 6773915
- Archival Resource Key: ark:/67531/metadc1199560
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Creation Date
- October 1, 1980
Added to The UNT Digital Library
- July 3, 2018, 8:14 a.m.
Description Last Updated
- Jan. 20, 2021, 10:16 p.m.
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Knapp, F. F. Jr. Nuclear medicine technology. Progress report, quarter ending March 31, 1980, report, October 1, 1980; Tennessee. (https://digital.library.unt.edu/ark:/67531/metadc1199560/: accessed July 16, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.