Studies on virus-induced cell fusion. Progress report, August 1, 1977--June 30, 1978 Metadata

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Title

  • Main Title Studies on virus-induced cell fusion. Progress report, August 1, 1977--June 30, 1978

Creator

  • Author: Person, S.
    Creator Type: Personal

Publisher

  • Name: Pennsylvania State Univ., University Park (USA)
    Place of Publication: United States

Date

  • Creation: 1978-07-01

Language

  • English

Description

  • Content Description: We have previously postulated that wild-type Herpes Simplex Virus type I (HSV-1) infections are characterized by the presence of a fusion factor and a fusion inhibitor activity. The fusion inhibitor presumably is dominant so that a small fraction of cells fuse in a typical wild-type infection. Furthermore, the syn mutants isolated in our laboratory are thought to cause extensive cell fusion because the production of active fusion inhibitor in cell membranes is delayed. If mutations existed that altered both the fusion factor and fusion inhibitor activity then separate viruses containing these two mutations might be able to complement each other, each supplying the defective gene product missing in the other virus. This would produce a wild type and not a syncytial mutant response. Complementation tests between two viruses, tsB5 and syn 20, which are thought to contain defects in the production of active fusion factor and fusion inhibitor activity, respectively, were done. A wild-type response was observed indicating that the mutations affecting fusion were in two separate genes.
  • Physical Description: 12 pages

Subject

  • Keyword: Diseases
  • Keyword: Herpes Simplex
  • Keyword: Glucoproteins
  • Keyword: Carbohydrates
  • Keyword: Organic Compounds
  • STI Subject Categories: 59 Basic Biological Sciences
  • Keyword: Kinetics
  • Keyword: Skin Diseases 550200* -- Biochemistry
  • Keyword: Proteins
  • Keyword: Saccharides
  • Keyword: Reaction Kinetics
  • Keyword: Cell Constituents
  • Keyword: Mutants
  • Keyword: Cell Membranes
  • Keyword: Infectivity
  • Keyword: Membranes
  • Keyword: Biochemical Reaction Kinetics
  • Keyword: Infectious Diseases
  • Keyword: Molecular Biology

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Report

Format

  • Text

Identifier

  • Report No.: COO-3419-19
  • Grant Number: EY-76-S-02-3419
  • DOI: 10.2172/6641713
  • Office of Scientific & Technical Information Report Number: 6641713
  • Archival Resource Key: ark:/67531/metadc1197474

Note

  • Display Note: Dep. NTIS, PC A02/MF A01.
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