Possibilities and problems in uv radiation carcinogenesis experiments Metadata

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Title

  • Main Title Possibilities and problems in uv radiation carcinogenesis experiments

Creator

  • Author: Fry, R.J.M.
    Creator Type: Personal
  • Author: Ley, R.D.
    Creator Type: Personal
  • Author: Grube, D.
    Creator Type: Personal

Publisher

  • Name: Oak Ridge National Laboratory
    Place of Publication: Tennessee
    Additional Info: Oak Ridge National Lab., TN (USA)
  • Name: Argonne National Laboratory
    Place of Publication: Illinois
    Additional Info: Argonne National Lab., IL (USA)

Date

  • Creation: 1978-01-01

Language

  • English

Description

  • Content Description: Experiments were designed to solve problems in dose-response relationships in uv-induced carcinogenesis. Two strains of hairless mice were exposed to 300 to 400 nm, 320 to 400 nm, and 365 nm wavelength emissions following exposure to 8-methoxy-psoralen; various fractionation regimes were used. Results showed that the number of psoralen-DNA crosslinks per cell increased linearly with dose. The importance of wavelength in the initiation and the expression of tumors is emphasized. (HLW)
  • Physical Description: 4 pages

Subject

  • Keyword: Chemical Reactions
  • Keyword: Mammals
  • Keyword: Organic Compounds
  • Keyword: Cross-Linking
  • Keyword: Drugs
  • Keyword: Electromagnetic Radiation
  • Keyword: Radiations
  • Keyword: Radioinduction
  • Keyword: Mice
  • Keyword: Radiosensitivity Effects
  • Keyword: Irradiation
  • Keyword: Carcinogenesis
  • Keyword: Animals
  • Keyword: Radiation Effects
  • Keyword: Organic Oxygen Compounds
  • Keyword: Vertebrates 560152* -- Radiation Effects On Animals-- Animals
  • Keyword: Fractionated Irradiation
  • Keyword: Biological Effects
  • Keyword: Nucleic Acids
  • Keyword: Wavelengths
  • Keyword: Biological Radiation Effects
  • STI Subject Categories: 63 Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat.
  • Keyword: Radiation Injuries
  • Keyword: Dose-Response Relationships
  • Keyword: Heterocyclic Compounds
  • Keyword: Injuries
  • Keyword: Psoralen
  • Keyword: Ultraviolet Radiation
  • Keyword: Dna
  • Keyword: Anticoagulants
  • Keyword: Pathogenesis
  • Keyword: Polymerization
  • Keyword: Rodents

Source

  • Conference: Solar radiation damage and the induction, of skin cancer, Lausanne, Switzerland, 26 Sep 1978

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Article

Format

  • Text

Identifier

  • Report No.: CONF-7809133-1
  • Grant Number: W-7405-ENG-26
  • Office of Scientific & Technical Information Report Number: 6293941
  • Archival Resource Key: ark:/67531/metadc1107416

Note

  • Display Note: Dep. NTIS, PC A02/MF A01.
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