title: Possibilities and problems in uv radiation carcinogenesis experiments
creator: Fry, R.J.M.
creator: Ley, R.D.
creator: Grube, D.
publisher: Oak Ridge National Laboratory
publisher: Argonne National Laboratory
date: 1978-01-01
language: English
description: Experiments were designed to solve problems in dose-response
 relationships in uv-induced carcinogenesis. Two strains of hairless mice were
 exposed to 300 to 400 nm, 320 to 400 nm, and 365 nm wavelength emissions
 following exposure to 8-methoxy-psoralen; various fractionation regimes were
 used. Results showed that the number of psoralen-DNA crosslinks per cell
 increased linearly with dose. The importance of wavelength in the initiation
 and the expression of tumors is emphasized. (HLW)
subject: Chemical Reactions
subject: Mammals
subject: Organic Compounds
subject: Cross-Linking
subject: Drugs
subject: Electromagnetic Radiation
subject: Radiations
subject: Radioinduction
subject: Mice
subject: Radiosensitivity Effects
subject: Irradiation
subject: Carcinogenesis
subject: Animals
subject: Radiation Effects
subject: Organic Oxygen Compounds
subject: Vertebrates 560152* -- Radiation Effects On Animals-- Animals
subject: Fractionated Irradiation
subject: Biological Effects
subject: Nucleic Acids
subject: Wavelengths
subject: Biological Radiation Effects
subject: 63 Radiation, Thermal, And Other Environ. Pollutant Effects On Living
 Orgs. And Biol. Mat.
subject: Radiation Injuries
subject: Dose-Response Relationships
subject: Heterocyclic Compounds
subject: Injuries
subject: Psoralen
subject: Ultraviolet Radiation
subject: Dna
subject: Anticoagulants
subject: Pathogenesis
subject: Polymerization
subject: Rodents
source: Solar radiation damage and the induction, of skin cancer, Lausanne,
 Switzerland, 26 Sep 1978
type: Article
format: 4 pages
format: Text
identifier: rep-no: CONF-7809133-1
identifier: grantno: W-7405-ENG-26
identifier: osti: 6293941
identifier: https://digital.library.unt.edu/ark:/67531/metadc1107416/
identifier: ark: ark:/67531/metadc1107416