Possibilities and problems in uv radiation carcinogenesis experiments
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Description
Experiments were designed to solve problems in dose-response relationships in uv-induced carcinogenesis. Two strains of hairless mice were exposed to 300 to 400 nm, 320 to 400 nm, and 365 nm wavelength emissions following exposure to 8-methoxy-psoralen; various fractionation regimes were used. Results showed that the number of psoralen-DNA crosslinks per cell increased linearly with dose. The importance of wavelength in the initiation and the expression of tumors is emphasized. (HLW)
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Description
Experiments were designed to solve problems in dose-response relationships in uv-induced carcinogenesis. Two strains of hairless mice were exposed to 300 to 400 nm, 320 to 400 nm, and 365 nm wavelength emissions following exposure to 8-methoxy-psoralen; various fractionation regimes were used. Results showed that the number of psoralen-DNA crosslinks per cell increased linearly with dose. The importance of wavelength in the initiation and the expression of tumors is emphasized. (HLW)
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Fry, R.J.M.; Ley, R.D. & Grube, D.Possibilities and problems in uv radiation carcinogenesis experiments,
article,
January 1, 1978;
Tennessee.
(https://digital.library.unt.edu/ark:/67531/metadc1107416/:
accessed July 16, 2024),
University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu;
crediting UNT Libraries Government Documents Department.
