Damage and repair of irradiated mammalian brain
Description
We have demonstrated that focal charged particle irradiation of the rabbit brain can create well-defined lesions which are observable by nuclear magnetic resonance imaging (NMR) and positron emission tomography (PET) imaging techniques. These are similar, in terms of location and characteristic NMR and PET features, to those that occur in the brain of about 10% of clinical research human subjects, who have been treated for intracranial vascular malformations with stereotactic radiosurgery. These lesions have been described radiologically as vasogenic edema of the deep white matter,'' and the injury is of variable intensity and temporal duration, can recede or progress to … continued below
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20 pages
Creation Information
Frankel, K.; Lo, E.; Phillips, M.; Fabrikant, J.; Brennan, K.; Valk, P. et al. July 1, 1989.
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Lawrence Berkeley Laboratory
Place of Publication: [Berkeley,] California
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Description
We have demonstrated that focal charged particle irradiation of the rabbit brain can create well-defined lesions which are observable by nuclear magnetic resonance imaging (NMR) and positron emission tomography (PET) imaging techniques. These are similar, in terms of location and characteristic NMR and PET features, to those that occur in the brain of about 10% of clinical research human subjects, who have been treated for intracranial vascular malformations with stereotactic radiosurgery. These lesions have been described radiologically as vasogenic edema of the deep white matter,'' and the injury is of variable intensity and temporal duration, can recede or progress to serious neurologic sequelae, and persist for a considerable period of time, frequently 18 mon to 3 yr. 8 refs., 6 figs.
Physical Description
20 pages
Notes
NTIS, PC A03/MF A01; OSTI; INIS; GPO Dep.
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Keywords
- Alkali Metal Isotopes
- Animals
- Antimetabolites
- Beta Decay Radioisotopes
- Beta-Plus Decay Radioisotopes
- Biological Effects
- Biological Materials
- Biological Radiation Effects
- Biological Recovery
- Biology
- Blood
- Blood Cells
- Body
- Body Fluids
- Brain
- Cat Scanning
- Central Nervous System
- Cerebrum
- Charged Particles
- Computerized Tomography
- Diagnostic Techniques
- Drugs
- Edema
- Electron Capture Radioisotopes
- Emission Computed Tomography
- External Irradiation
- Fluorodeoxyglucose
- Helium Ions
- Hours Living Radioisotopes
- Injuries
- Intermediate Mass Nuclei
- Ions
- Irradiation
- Isotopes
- Mammals
- Materials
- Minutes Living Radioisotopes
- Nervous System
- Nmr Imaging
- Nuclei
- Odd-Odd Nuclei
- Organs
- Pathological Changes
- Patients
- Positron Computed Tomography
- Rabbits
- Radiation Effects
- Radiation Injuries
- Radiobiology
- Radioisotopes
- Recovery
- Rubidium 82
- Rubidium Isotopes
- Symptoms
- Tomography
- Vertebrates 560152* -- Radiation Effects On Animals-- Animals
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Source
- American Association for the Advancement of Science (AAAS) annual meeting, San Francisco, CA (USA), 14-19 Jan 1989
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- Other: DE90000141
- Report No.: LBL-27582
- Report No.: CONF-890124--5
- Grant Number: AC03-76SF00098
- Office of Scientific & Technical Information Report Number: 5585394
- Archival Resource Key: ark:/67531/metadc1084829
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Reports, articles and other documents harvested from the Office of Scientific and Technical Information.
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Creation Date
- July 1, 1989
Added to The UNT Digital Library
- Feb. 10, 2018, 10:06 p.m.
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- May 14, 2019, 5:36 p.m.
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Frankel, K.; Lo, E.; Phillips, M.; Fabrikant, J.; Brennan, K.; Valk, P. et al. Damage and repair of irradiated mammalian brain, article, July 1, 1989; [Berkeley,] California. (https://digital.library.unt.edu/ark:/67531/metadc1084829/: accessed July 17, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.