Linear-quadratic dose kinetics or dose-dependent repair/misrepair

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Models for the response of cells exposed to low LET radiation can be grouped into three general types on the basis of assumptions about the nature of the interaction which results in the shoulder of the survival curve. The three forms of interaction are (1) sublethal damage becoming lethal, (2) potentially lethal damage becoming irreparable, and (3) potentially lethal damage saturating'' a repair system. The effects that these three forms of interaction would have on the results of specific types of experiments are investigated. Comparisons with experimental results indicate that only the second type is significant in determining the response … continued below

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5 pages

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Braby, L.A. & Nelson, J.M. September 1, 1991.

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Models for the response of cells exposed to low LET radiation can be grouped into three general types on the basis of assumptions about the nature of the interaction which results in the shoulder of the survival curve. The three forms of interaction are (1) sublethal damage becoming lethal, (2) potentially lethal damage becoming irreparable, and (3) potentially lethal damage saturating'' a repair system. The effects that these three forms of interaction would have on the results of specific types of experiments are investigated. Comparisons with experimental results indicate that only the second type is significant in determining the response of typical cultured mammalian cells. 5 refs., 2 figs.

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5 pages

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OSTI; NTIS; GPO Dep.

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  • Workshop on biophysical modelling of radiation effects, Padua (Italy), 2-5 Sep 1991

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  • Other: DE92002139
  • Report No.: PNL-SA-20040
  • Report No.: CONF-9109107--3
  • Grant Number: AC06-76RL01830
  • Office of Scientific & Technical Information Report Number: 5011735
  • Archival Resource Key: ark:/67531/metadc1060095

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  • September 1, 1991

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  • Jan. 22, 2018, 7:23 a.m.

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  • May 28, 2019, 12:56 p.m.

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Braby, L.A. & Nelson, J.M. Linear-quadratic dose kinetics or dose-dependent repair/misrepair, article, September 1, 1991; Richland, Washington. (https://digital.library.unt.edu/ark:/67531/metadc1060095/: accessed July 16, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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