Modulation of ³H-Myo-Inositol Uptake by Glucose and Sorbitol in Cultured Bovine Lens Epithelial Cells

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Myo-[3H]-inositol accumulation in cultured bovine lens epithelial cells (BLECs) occurred by both high- and low affinity, Nat-dependent transport sites. High ambient glucose significantly inhibited myo-[ 3 H]-inositol uptake; the co-administration of sorbinil, an aldose reductase inhibitor, prevented the inhibitory effect on the low affinity transport site. A glucose-sensitive process for myo-[3 H]-inositol uptake on the high-affinity transport site was uncovered by Lineweaver-Burk analysis. Dixon plot analysis confirmed that the effect of glucose was due to competitive inhibition of the high-affinity myo-inositol transport site while the effect of sorbitol was due to competitive inhibition of the low-affinity myo-inositol transport site.

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viii, 107 leaves : ill.

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Chen, Hai-Qing August 1992.

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  • Chen, Hai-Qing

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Myo-[3H]-inositol accumulation in cultured bovine lens epithelial cells (BLECs) occurred by both high- and low affinity, Nat-dependent transport sites. High ambient glucose significantly inhibited myo-[ 3 H]-inositol uptake; the co-administration of sorbinil, an aldose reductase inhibitor, prevented the inhibitory effect on the low affinity transport site. A glucose-sensitive process for myo-[3 H]-inositol uptake on the high-affinity transport site was uncovered by Lineweaver-Burk analysis. Dixon plot analysis confirmed that the effect of glucose was due to competitive inhibition of the high-affinity myo-inositol transport site while the effect of sorbitol was due to competitive inhibition of the low-affinity myo-inositol transport site.

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viii, 107 leaves : ill.

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  • Call Number: 379 N81 no.6818
  • OCLC: 28463289
  • Accession or Local Control No: 1002778448-Chen
  • Archival Resource Key: ark:/67531/metadc500656

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  • August 1992

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Chen, Hai-Qing. Modulation of ³H-Myo-Inositol Uptake by Glucose and Sorbitol in Cultured Bovine Lens Epithelial Cells, thesis, August 1992; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc500656/: accessed May 1, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .

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