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Muscarinic Receptor Modulation of the Phospholipid Effect in Cardiac Myocytes

Description: The muscarinic agonist carbachol stimulates a rapid increase in ^32Pi incorporation into phosphatidic acid (PA) and phosphatidylinositol (PI) in calcium tolerant myocytes prepared from heart tissue. The density of muscarinic receptors, determined by [^3H]-QNB binding, is greater in the atria than in the ventricles. 250 uM carbachol decreased specific [^3H]-QNB binding to muscarinic receptors on myocyte membranes by fifty percent. Trifluoperazine, also a phospholipase C inhibitor, inhibited the … more
Date: May 1986
Creator: Mattern, Janet
Partner: UNT Libraries
open access

Discriminative Stimulus Properties of Cocaine: Tolerance and Cross-Tolerance Characteristics

Description: Rats were trained to discriminate an injection of cocaine, 5.0 mg/kg, from an injection of saline, using a two-lever choice paradigm: one lever was correct after cocaine injection, the other lever was correct after a saline injection. After training, cocaine and methamphetamine were generalized to the cocaine lever, but phenethylamine (PEA) was only partially generalized. Cocaine was injected every 8 hrs, 20.0 mg/kg, and the discriminability of 5.0 mg/kg was tested every other day. Redetermina… more
Date: May 1985
Creator: Wood, Douglas M. (Douglas Michael)
Partner: UNT Libraries
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