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in creator/contributor: "Bull, Richard J."

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Mechanism Involved in Trichloroethylene-Induced Liver Cancer: Importance to Environmental Cleanup

The objective of this project is to develop critical data for improving risk-based cleanup standards for trichloroethylene (TCE). Importance to DOE. Cleanup costs for chlorinated solvents found on DOE sites are most frequently driven by TCE because it is the most widespread contaminant and is generally present at the highest concentrations. Data that would permit increases in risk-based standards for TCE would reduce complex wide cleanup costs by hundreds of millions of dollars. Current Regulat… more

Date: June 1, 1999

Creator: Bull, Richard J. & Thrall, Brian D.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Mechanisms Involved in Trichloroethylene-Induced Liver Cancer: Importance to Environmental Cleanup

The project is organized around two interrelated tasks: Task 1 develops the basic dosimetry parameters and provides in vivo data describing the mode of action tumorigenic and for the metabolites of TCE that produce liver cancer in mice, dichloroacetate (DCA) and trichloroacetate (TCA). Early work suggested that TCA was primarily responsible for TCE-induced liver tumor. More recent, mechanistic observations indicated that DCA played a prominent role. Therefore, studies were designed to determine… more

Date: June 1, 2000