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Cellular Biomarkers for Measuring Toxicity of Xenobiotics: Effects of PCBs on Earthworm Lumbricus Terrestris Coelomocytes

Description: The research presented herein provides information on coelomocyte (leukocyte) collection, function and immunotoxicity from polychlorinated biphenyls (PCB) in the earthworm Lumbricus terrestris. Research was undertaken as part of an overall goal to develop a well-documented and scientifically valid non-mammalian surrogate immunoassay with the earthworm Lumbricus terrestris to assess immunotoxic potential of xenobiotics. The principal objectives were to: (1) Develop an extrusion model for analyzi… more
Date: May 1991
Creator: Eyambe, George Sona
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Evaluation of Sequential Events in Phagocytosis by Earthworm Coelomocytes as Potential Immunotoxicity Biomarkers

Description: This research evaluated the potential of activation and attachment, as sequential companion biomarkers of phagocytosis by earthworm, Lumbricus terrestris, immunoactive coelomocytes for use in immunotoxicology. The potential was assessed by exposing earthworms to sublethal concentrations of CuSO4 and Arochlor 1254®, chemicals used as reference or standard immunotoxicants.
Date: August 1998
Creator: Murray, Stephanie Mae
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Immunotoxicity of Chromium Contaminated Soil in the Earthworm, Lumbricus Terrestris

Description: Objective was to assess the toxicity of chromium (Cr) contaminated soil (CS) using the earthworm Lumbricus terrestris. Specific aims were to determine: (1) survival (LC50); .(2) immunotoxicity as indicated by lysozyme activity, coelomocyte counts, secretory (SR) and erythrocyte rosette (ER) formation, and phagocytosis; and (3) compare effects of CS exposure with those of Cr spiked artificial soil (AS) . CS Cr concentration was 8.78 mg/g with 98.2% being Cr^3+ and 1.8% being Cr^6+. Using 14 d AS… more
Date: May 1993
Creator: Mohammadian, Gholamreza
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Evaluation of Immune Responses and Cytological Changes in Lumbricus Terrestris and Eisenia Foetida as Assays for Xenobiotics

Description: The earthworms, Lubricus terrestris and Eisenia foetida, were used as non mammalian surrogate models to assess the immunotoxicpotential of xenobiotic to mammals. Assays were developed and optimized for detecting spreading activity and phagocytosis of rabbit red blood cell (RRBC), bacteria, and yeasts by macrophage-like coelomocytes of L. terrestris.
Date: December 1992
Creator: Hariri, Abdolrahman Sadeghi
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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