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in subjects: "Pathology"

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Detecting nonlinearity and chaos in epidemic data

Historical data on recurrent epidemics have been central to the debate about the prevalence of chaos in biological population dynamics. Schaffer and Kot who first recognized that the abundance and accuracy of disease incidence data opened the door to applying a range of methods for detecting chaos that had been devised in the early 1980`s. Using attractor reconstruction, estimates of dynamical invariants, and comparisons between data and simulation of SEIR models, the ``case for chaos in childh… more

Date: August 1, 1993

Creator: Ellner, S.; Gallant, A. R. & Theiler, J.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Correlation of chromosome patterns in human leukemic cells with exposure to chemicals and/or radiation. Progress report, July 1992--August 1993

Progress in identification of chromosomal transformations associated with leukemogenesis is described. In particular progress in DNA cloning of chromosomal break points in human cancer patients is described.

Date: September 1, 1993

Creator: Rowley, J. D.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Lipoprotein subclasses in genetic studies: The Berkeley Data Set

Data from the Berkeley Data Set was used to investigate familial correlations of HDL-subclasses. Analysis of the sibling intraclass correlation coefficient by HDL particle diameter showed that sibling HDL levels were significantly correlated for HDL{sub 2b}, HDL{sub 3a} and HDL{sub 3b} subclasses. The percentage of the offsprings` variance explained by their two parents. Our finding that parents and offspring-have the highest correlation for HDL{sub 2b} is consistent with published reports that… more

Date: October 1, 1992

Creator: Krauss, R. M.; Williams, P. T.; Blanche, P. J.; Cavanaugh, A.; Holl, L. G. & Austin, M. A.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Conceptual design of an 8 Tesla superconducting wiggler for a dedicated digital subtraction angiography source

One of the most important techniques used to diagnose heart disease is coronary angiography. Coronary angiography is only used when it is absolutely essential because of the risk of fatalities and other serious complications arising from the insertion of the catheter. The technique also exposes the patients to large amounts of x-rays. Research, begun at SSRL and continued on the X17 beam line at NSLS, demonstrated the feasibility of imaging human coronary arteries following venous injection of … more

Date: September 1, 1993

Creator: Blum, E. B.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Supersensitive in Situ Hybridization by Tyramide Signal Amplification and Nanogold Silver Staining: The Contribution of Autometallography and Catalyzed Reporter Deposition to the Rejuvenation of In Situ Hybridization

It is peculiar that in situ hybridization (ISH), a technique with many similarities to immunohistochemistry (IHC), has not enjoyed the phenomenal growth in both basic research and clinical applications as has its sister technique IHC. Since the late 1970s, when immunoperoxidase techniques began to be applied to routine diagnostic material and to numerous research applications, there has been a natural evolution of the IHC procedure. Namely, only a few primary antibodies were available commercia… more

Date: April 17, 2002

Creator: Tubbs, Raymond R.; Pettay, James; Grogan, Thomas; Powell, R. D.; Cheung, Annie L. M.; Hainfeld, James et al.

Item Type: Book

Partner: UNT Libraries Government Documents Department

open access

Relationships between ''C'' type particle production, nuclear pocket frequency and immunofluorescense serology titer in calves inoculated with bovine ''C'' type particles. [Etiology and pathogenesis of bovine leukemia]

Progress is reported on studies on the etiology and pathogenesis of bovine leukemia following inoculation of newborn calves and fetuses up to 60 days prior to birth with lymphocytes from infected source animals. (CH)

Date: January 1, 1975

Creator: Pomeroy, K. A. & Olson, J. M.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

PCR detection of retinoblastoma gene deletions in radiation-induced mouse lung adenocarcinomas

From 1971 to 1986, Argonne National Laboratory conducted a series of large-scale studies of tumor incidence in 40,000 BCF{sub 1} mice irradiated with {sup 60}Co {gamma} rays or JANUS fission-spectrum neutrons; normal and tumor tissues from mice in these studies were preserved in paraffin blocks. A polymerase chain reaction (PCR) technique has been developed to detect deletions in the mouse retinoblastoma (mRb) gene in the paraffin-embedded tissues. Microtomed sections were used as the DNA sourc… more

Date: April 1, 1993

Creator: Churchill, M. E.; Gemmell, M. A. & Woloschak, G. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Dose-response relationships for female radium dial workers: A new look

The values of initial systemic intake and of skeletal dose for all of the U.S. radium cases have recently been revised. This revision was required following the demonstrations by Rundo and by Keane that humans who were exposed to radium as adults lost radium at a rate that depended on the quantity of radium originally deposited within their bodies. These new values have been used to define new dose-response relationships for both the bone sarcomas and the carcinomas arising in the paranasal sin… more

Date: May 1, 1994

Creator: Rowland, R. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Biological Monitoring and Abatement Program for the Oak Ridge K-25 Site

A proposed Biological Monitoring and Abatement Program (BMAP) for the Oak Ridge K-25 Site was prepared in December 1992 as required by the renewed National Pollutant Discharge Elimination System permit that was issued on October 1, 1992. The proposed BMAP consists of four tasks that reflect different but complementary approaches to evaluating the effects of K-25 Site effluents on the ecological integrity of Mitchell Branch, Poplar Creek, and the Poplar Creek embayment of the Clinch River. These… more

Date: February 1, 1993

Creator: Kszos, L. A.; Adams, S. M.; Ashwood, T. L.; Blaylock, B. G.; Greeley, M. S.; Loar, J. M. et al.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Primary bone neoplasms; Revision 2

Canine appendicular osteosarcoma is a serious cancer that causes lameness due to its aggressive local effects and death due to early and widespread metastases. Amputation alone is palliative, with a 10% rate of survival to 1 year. Cisplatin chemotherapy (with or without doxorubicin) improves the chances of survival, but metastatic cancer is still the cause of death in most affected dogs. Limb sparing may be a viable alternative in some dogs.

Date: March 1, 1994

Creator: Weller, R. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Tumorigenesis in the U.S. radium luminizers: How unsafe was this occupation?

Dose-response data are presented from the U.S. female workers who were exposed to radium through the painting of luminous dials and who subsequently had their skeletal burdens measured by whole-body counting and radon breath analyses. Lognormal data analyses were done for radium-induced bone sarcomas and head carcinomas after the populations of the respective doses were first determined to be lognormally distributed. The calculated geometric mean and standard deviation for each dose population … more

Date: May 1, 1994

Creator: Thomas, R. G.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Paraneoplastic syndromes

Paraneoplastic syndromes (PNS) comprise a diverse group of disorders that are associated with cancer but unrelated to the size, location, metastases, or physiologic activities of the mature tissue of origin. They are remote effects of tumors that may appear as signs, symptoms, or syndromes which can mimic other disease conditions encountered in veterinary medicine. Recognition of PNS is valuable for several reasons: the observed abnormalities may represent tumor cell markers and facilitate earl… more

Date: March 1, 1994

Creator: Weller, R. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

DM-CSF stimulated proliferation of rat alveolar macrophages and the effects of differing particulate burden levels in alveolar macrophages on the proliferative response

Particles are gradually redistributed among the lung`s population of alveolar macrophages (AM) at times well after they were originally deposited in the lung. One mechanism that may underlie this ``particle redistribution phenomenon`` is the in situ replication of particle-containing AM and the allocation of particles from dividing AM to daughter cells. Little is known about how the abilities of AM to proliferate may be affected by the containment of particles; conceivably, AM proliferation may… more

Date: May 1, 1993

Creator: Pendergrass, D.; Valdez, Y. E. & Lehnert, B. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

SNODOG Glossary: Part 1, Introduction

The SNODOG Glossary is used by the DOE-supported life-span beagle studies to describe medical observations in a standardized format. It is an adaptation of the human medical glossary, SNOMED, which lists 107,165 terms. Each of the five laboratories, Argonne National Laboratory, the Inhalation Toxicology Research Institute, the Pacific Northwest Laboratory, the University of California at Davis, and the University of Utah, has selected an appropriate subset from the published SNOMED glossary and… more

Date: April 15, 1993

Creator: Watson, C. R.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Alu repeats as markers for forensic DNA analyses

The Human-Specific (HS) subfamily of Alu sequences is comprised of a group of 500 nearly identical members which are almost exclusively restricted to the human genome. Individual subfamily members share an average of 98.9% nucleotide identity with the HS subfamily consensus sequence, and have an average age of 2.8 million years. We have developed a Polymerase Chain Reaction (PCR) based assay using primers complementary to the 5 inch and 3 inch unique flanking DNA sequences from each HS Alu that… more

Date: January 1, 1994

Creator: Batzer, M. A.; Alegria-Hartman, M. & Kass, D. H.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Pulmonary macrophages: Phenomena associated with the particle ``overload`` condition

Numerous lines of evidence support the generalization that alveolar macrophage (AM)-mediated particle clearance, or the transport of particle-containing AM from the alveoli out of the lung via the mucociliary apparatus, is a prominent mechanism that determines the pulmonary retention characteristics of relatively insoluble particles. Studies have also shown that the alveolar deposition of excessive burdens of particles with even low intrinsic cytotoxicity can result in impairments of the AM-med… more

Date: May 1, 1993

Creator: Lehnert, B. E.; Sebring, R. J. & Oberdoerster, G.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

HIV transcription is induced with some forms of cell killing

No Description Available.

Date: August 1, 1994

Creator: Woloschak, G. E.; Chang-Liu, Chin-Mei; Schreck, S.; Panozzo, J. & Libertin, C. R.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Development of a neural net paradigm that predicts simulator sickness

A disease exists that affects pilots and aircrew members who use Navy Operational Flight Training Systems. This malady, commonly referred to as simulator sickness and whose symptomatology closely aligns with that of motion sickness, can compromise the use of these systems because of a reduced utilization factor, negative transfer of training, and reduction in combat readiness. A report is submitted that develops an artificial neural network (ANN) and behavioral model that predicts the onset and… more

Date: March 1, 1993

Creator: Allgood, G. O.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Malignant melanoma slide review project: Patients from non-Kaiser hospitals in the San Francisco Bay Area. Final report

This project was initiated, in response to concerns that the observed excess of malignant melanoma among employees of Lawrence Livermore National Laboratory (LLNL) might reflect the incidence of disease diagnostically different than that observed in the general population. LLNL sponsored a slide review project, inviting leading dermatopathology experts to independently evaluate pathology slides from LLNL employees diagnosed with melanoma and those from a matched sample of Bay Area melanoma pati… more

Date: January 5, 1993

Creator: Reynolds, P.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Umatilla Hatchery Satellite Facilities; Operations and Maintenance, Annual Report 2001.

The Confederated Tribes of the Umatilla Indian Reservation (CTUIR) and Oregon Department of Fish and Wildlife (ODFW) are cooperating in a joint effort to enhance steelhead and re-establish salmon runs in the Umatilla River Basin. As an integral part of this program, Bonifer Pond, Minthorn Springs, Imeques C-mem-ini-kem, Thornhollow and Pendleton satellite facilities are operated for acclimation and release of juvenile summer steelhead (Oncorhynchus mykiss), fall and spring chinook salmon (O. ts… more

Date: May 1, 2003

Creator: Rowan, Gerald

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Quis custodiet ipsos custodies: who watches the watchmen?

Should this be said again? No cell is an island and in tissue-specificity and cancer, context is supreme. Decades ago, seminal recombination experiments illustrated the dominant role of mammary mesenchyme in directing epithelial development, and strongly suggested that the microenvironment plays a significant role also in the manifestation of carcinoma. More direct evidence for such functions came from a study demonstrating that an unadulterated microenvironment can suppress the malignant pheno… more

Date: June 3, 2009

Creator: Ghajar, Cyrus M.; Meier, Roland & Bissell, Mina J.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Complex biological and bio-inspired systems

The understanding and characterization ofthe fundamental processes of the function of biological systems underpins many of the important challenges facing American society, from the pathology of infectious disease and the efficacy ofvaccines, to the development of materials that mimic biological functionality and deliver exceptional and novel structural and dynamic properties. These problems are fundamentally complex, involving many interacting components and poorly understood bio-chemical kine… more

Date: January 1, 2009

Creator: Ecke, Robert E

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Operation and Maintenance of the National Radiobiology Archives

The National Radiobiology Archives (NRA) are an archival program, started in 1989, to collect, organize and maintain data, laboratory notebooks, and animal tissue specimens from government (Department of Energy and its predecessor agencies) sponsored radiobiology life-span animal studies. These unique records, histopathology slides and paraffin embedded tissue blocks are maintained in a central facility and are available for further research study. The materials include electronic and paper rec… more

Date: March 7, 2012

Creator: James, Dr. Anthony C. & McCord, Stacey L.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer

Breast cancer is predominantly a disease of the genome with cancers arising and progressing through accumulation of aberrations that alter the genome - by changing DNA sequence, copy number, and structure in ways that that contribute to diverse aspects of cancer pathophysiology. Classic examples of genomic events that contribute to breast cancer pathophysiology include inherited mutations in BRCA1, BRCA2, TP53, and CHK2 that contribute to the initiation of breast cancer, amplification of ERBB2 … more

Date: June 18, 2009

Creator: Spellman, Paul T.; Heiser, Laura & Gray, Joe W.

Item Type: Book

Partner: UNT Libraries Government Documents Department