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Drug metabolizing enzyme systems and their relationship to toxic mechanisms

Description: The metabolism and toxicity of 3-methylfuran (3-MF) are described. The major product of metabolic activation of 3-MF appears to be disemicarbazones. Cursory description of toxic effects of 3-MF on lung and kidneys are provided. 18 refs.
Date: January 1, 1983
Creator: Boyd, M. R.; Ravindranath, V.; Burka, L. T.; Dutcher, J. S.; Franklin, R. B.; Statham, C. N. et al.
Partner: UNT Libraries Government Documents Department
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Multiheteromacrocycles that complex metal ions. Sixth progress report, 1 May 1979-30 April 1980. [Hemispherands; spherands]

Description: Objective is to design synthesize, and evaluate cyclic and polycyclic host organic compounds for their abilities to complex and lipophilize guest metal ions, their complexes, and their clusters. Host organic compounds consist of strategically placed solvating, coordinating, and ion-pairing sites tied together by covalent bonds through hydrocarbon units around cavities shaped to be occupied by guest metal ions or by metal ions plus their ligands. Specificity in complexation is sought by matching… more
Date: January 15, 1980
Creator: Cram, D. J.
Partner: UNT Libraries Government Documents Department
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Kilowatt Isotope Power System: component report for the Ground Demonstration System Accumulator

Description: The Model Number ORC1A3A01 System Accumulator for the Kilowatt Isotope Power System was expulsion tested and demonstrated to be in compliance with the requirements of Sundstrand Explusion Test Procedure, TP 400. Test requirements of TP 400 were extracted from the Kilowatt Isotope Power System, Ground Demonstration System Test Plan.
Date: January 31, 1978
Creator: Brainard, E.L.
Partner: UNT Libraries Government Documents Department
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Pentamethylcyclopentadienyl and bis(trimethylsilyl)amido complexes of the di- and trivalent lanthanides

Description: The reaction of the divalent iodides YbI/sub 2/ and EuI/sub 2/ with NaN(SiMe/sub 3/)/sub 2/ has provided pentane-soluble, monomeric derivatives of the divalent lanthanides. These compounds are isolated as the solvated species Eu(N(SiMe/sub 3/)/sub 2/)/sub 2/L/sub 2/ (L = thf or 1,2-dme), Yb(N(SiMe/sub 3/)/sub 2/)/sub 2/(thf)/sub 1/ /sub 5/ and Yb(N(SiMe/sub 3/)/sub 2/)/sub 2/L/sub 2/ (L = 1,2-dme or OEt/sub 2/), or as the sodium salts NaM(N(SiMe/sub 3/)/sub 2/)/sub 3/ (M = Eu or Yb). The pentam… more
Date: March 1, 1982
Creator: Tilley, T. D.
Partner: UNT Libraries Government Documents Department
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TFTR coil case design

Description: The TFTR (TOKAMAK Fusion Test Reactor) TF (Toroidal Field) coil cases are highly loaded structures designed within severe constraints. Foremost among these are basic machine geometry, material characteristics of both the case and the copper/epoxy matrix it supports, and overall cost. Scoping and parametric studies have been performed continuously since conceptual design. The progression of design decisions including coil shape, support locations and their stiffnesses, material selection, and el… more
Date: January 1, 1977
Creator: Pusateri, J.; Barnes, G. & Citrolo, J.
Partner: UNT Libraries Government Documents Department
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Cationically polymerizable monomers derived from renewable sources

Description: The objective of this project is to make use of products obtained from renewable plant sources as monomers for the direct production of polymers which can be used for a wide range of plastic applications. In this report is described progress in the synthesis and polymerization of cationically polymerizable monomers and oligomers derived from botanical oils, terpenes, natural rubber, and lignin. Nine different botanical oils were obtained from various sources, characterized and then epoxidized. … more
Date: October 1, 1991
Creator: Crivello, J. V.
Partner: UNT Libraries Government Documents Department
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Facile reaction/extraction of coal with supercritical fluids. Quarterly technical progress report, January 1-March 31, 1984

Description: Arylmethyl phenyl ethers undergo competing reactions when treated with Lewis acids in benzene solvent. Apparently, benzene is insufficiently reactive to compete with intramolecular (intrapolymer) nucleophiles and, consequently, no increase in solubility accompanies the cleavages of ether links upon addition of benzene. When better nucleophiles, naphthalene and phenanthene, are provided, carbonium ions generated from ether cleavages are capped and the product is lower in molecular weight and mor… more
Date: April 20, 1984
Creator: Venier, C. G. & Squires, T. G.
Partner: UNT Libraries Government Documents Department
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Process and analytical studies of enhanced low severity co-processing using selective coal pretreatment

Description: This report describes progress on research during the eleventh quarter of this contract dealing with applications of coal pretreatment techniques in coal/oil co-processing and direct hydroliquefaction. The objectives of the project are to investigate various coal pretreatment techniques and to determine the effect of these pretreatment procedures on the reactivity of the coal. Reactivity enhancement will be evaluated under both direct hydroliquefaction and co-processing conditions. Coal convers… more
Date: 1991-06~
Creator: Baldwin, R. M.; Gaur, S. & Miller, R. L.
Partner: UNT Libraries Government Documents Department
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Damage to fused silica windows while under simultaneous exposure to flowing solvents and laser radiation and 308nm

Description: This paper reports the results of a study to determine the degrading effects of flowing dye solvents on the laser damage threshold of fused-silica windows at 308nm. Thresholds were measured at the SiO/sub 2/solvent interface in a test cell. Bare SiO/sub 2/ tested in air at 308nm (20ns) typically exhibits a threshold ranging from 4 to 10 Jcm/sup 2/; with the solvent cyclohexane in contact, a threshold as low as 0.3 Jcm/sup 2/ was measured. The damage data indicate that window lifetime (number of… more
Date: January 1, 1987
Creator: Mauro, B. R.; Foltyn, S. R. & Sanders, V. E.
Partner: UNT Libraries Government Documents Department
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Dynamic shear behavior of alumina-filled epoxy

Description: Thin-walled tubular specimens of alumina-filled epoxy were loaded in torsion at a strain rate of approximately 10/sup 3/ s/sup -1/ using a stored-torque Kolsky bar. In addition to measuring the time resolved shear stress and shear strain in the specimen, the axial stress generated by the dilation of the material during shear deformation was also obtained as a function of time. Tests were conducted at room temperature and at -60/sup 0/C. At room temperature, a moderate amount of plastic deformat… more
Date: March 1, 1982
Creator: Costin, L.S.
Partner: UNT Libraries Government Documents Department
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Mechanisms for radiation damage in DNA. Progress report, January 1, 1982-December 31, 1982

Description: In this project several mechanisms are proposed for radiation damage to DNA constituents and DNA, and a series of experiments utilizing electron spin resonance spectrometry to test the proposed mechanisms have been detailed. In the past studies have concentrated chiefly on the direct effect of radiation on DNA. We are currently investigating irradiated systems of DNA constituents which may shed light on indirect effects. In addition, studies of radiation effects on lipids have been undertaken w… more
Date: May 1, 1982
Creator: Sevilla, M. D.
Partner: UNT Libraries Government Documents Department
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Stability and compatibility studies with the inorganic explosive 2-(5-cyanotetrazolato)pentaamminecobalt(III) perchlorate (CP)

Description: 2-(5-Cyanotetrazolato)pentaamminecobalt(III) perchlorate (CP) is an inorganic secondary explosive that has been developed for applications involving deflagration-to-detonation transition. Previously the primary explosives lead azide and lead styphnate had been used. Stability and compatibility studies with CP have been conducted for periods up to three years. By using the rate of formation of cobalt(II) as the prime stability measurement for CP no reaction above baseline has been observed at te… more
Date: January 1, 1980
Creator: Massis, T. M.; Morenus, P. K.; Huskisson, D. H. & Merrill, R. M.
Partner: UNT Libraries Government Documents Department
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Heavy recycle solvent studies in two-stage coal liquefaction. Final technical report, September 1, 1982-December 30, 1983

Description: The objective of this program has been to study the chemistry of the components with high boiling points in a direct coal liquefaction recycle solvent and to identify those components which lead to higher overall yields and improved product stability in the initial coal dissolution step of direct coal liquefaction processes. The major conclusions are: -454 C recycle solvent is primarily aromatic hydrocarbons (73%) and contains almost no asphaltenes; +454 C recycle solvent is primarily asphalten… more
Date: January 10, 1984
Creator: Longanbach, J. R.
Partner: UNT Libraries Government Documents Department
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Palladium Catalyzed Coupling Reactions: Mechanism of Reductive Elimination. Progress Report, October 1, 1979-September 30, 1980. [Ethane Elimination]

Description: The 1,1-reductive elimination of ethane from three cis-bis(phosphine)-dimethylpalladium complexes, L/sub 2/Pd(CH/sub 3/)/sub 2/ (L = PPh/sub 3/, PPh/sub 2/,CH/sub 3/ and L/sub 2/ = Ph/sub 2/PCH/sub 2/CH/sub 2/PPh/sub 2/), and three trans analogs (L = PPh/sub 3/, PPh/sub 2/CH/sub 3/ and L/sub 2/ = 2,11-bis(diphenylphosphinomethyl)benzo(c)phenanthrene (TRANSPHOS)) was carried out. The three cis complexes underwent reductive elimination in the presence of coordinating solvents (DMSO, DMF, and THF)… more
Date: September 1, 1980
Creator: Stille, J. K.
Partner: UNT Libraries Government Documents Department
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Development of high-mechanical strength electrical insulations for tokamak toroidal field coils

Description: The electrical insulation for the TF (Toroidal Field) coils is subjected to a high interlaminar shear, tensile and compressive stresses. Two candidate epoxy/glass fiber systems using prepreg and vacuum impregnation techniques were evaluated. Specimens were prepared and processed under controlled conditions to simulate specification manufacturing procedures. The strengths of the insulation were measured in interlaminar shear, tension, compression, and combined shear and compression statically. S… more
Date: January 1, 1977
Creator: Burke, C.
Partner: UNT Libraries Government Documents Department
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Chemical characterization of CTBN (carboxyl-terminated butadiene/acrylonitrile) and its epoxy adduct

Description: This report describes the analysis of carbonxyl-terminated butadiene (CTB), carboxyl-terminated butadiene/acrylonitrile (CTBN), and a CTBN adduct prepared by reaction with Epon 828. Data from gel permeation chromatography, nuclear magnetic resonance spectroscopy, high performance liquid chromatography, and ion chromatography are presented and discussed. Quantitative methods based on carbon-13 and proton NMR for analyzing CTBN are described. Proton NMR was found to be useful in identifying lots … more
Date: January 1, 1990
Creator: Smith, R.E.
Partner: UNT Libraries Government Documents Department
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Effect of water-bearing fiber in Kevlar 49-epoxy composites

Description: Water has been observed to be adsorbed, and possibly absorbed, by desiccated Kevlar 49 fiber to 6 percent of the fiber weight in 100 percent relative humidity. The effect of the water on the transverse flexural strength and elastic modulus of an aliphatic amine-cured epoxy, unidirectionally reinforced with saturated Kevlar 49, has been determined. Such composites are weaker than those made with fiber equilibrated to 0 percent relative humidity, and the effect persists after a 75/sup 0/C, 16-h p… more
Date: January 1, 1978
Creator: Moss, M.
Partner: UNT Libraries Government Documents Department
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Control of catalytic hydrotreating selectivity with ammonia. [Hydrodeoxygenation]

Description: The hydrogenation of naphthalene in the presence of 0, 24, or 48 kPa of ammonia derived from propyl amine was studied during the hydrodeoxygenation (HDO) of dibenzofuran (DBF). A new sample of sulfided NiMo/Al{sub 2}O{sub 3} catalyst at 360{degrees}C, 6.9 MPa total H{sub 2} pressure in a vapor phase tubular reactor was used. As a base-line the HDO of DBF was also studied in the absence of both naphthalene and ammonia. Ammonia inhibited both the HDO of dibenzofuran and the hydrogenation of napht… more
Date: January 1, 1992
Creator: Satterfield, C. N. & Lee, C. M.
Partner: UNT Libraries Government Documents Department
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Morphology and phase composition of an amine cured rubber modified epoxy

Description: The sharpness of the interface between the matrix and the dispersed phase, the volume fraction of the dispersed phase, the distribution of particle sizes, and the concentration of epoxy in the dispersed phase were determined. Scanning transmission electron microscopy coupled with energy dispersive x-ray analysis revealed that the interface width is less than 500 A. Variation of the fraction of mobile hydrogens with temperature determined by nuclear magnetic resonance indicated that a small frac… more
Date: January 1, 1980
Creator: Sayre, J. A.; Assink, R. A. & Lagasse, R. R.
Partner: UNT Libraries Government Documents Department
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Hydrogen-Transfer and Charge Transfer in Photochemical and High Energy Radiation Induced Reactions: Effects of Thiols. Final Report, February 1, 1960-January 31, 1979

Description: Absorption of ultraviolet or visible light, or high energy radiation, may lead to highly reactive free radicals. Thiols affect the reactions of these radicals in the following ways: (1) transfer of hydrogen from sulfur of the thiol to a substrate radical, converting the radical to a stable molecule, and the thiol to a reactive thiyl radical; and (2) transfer of hydrogen from a substrate radical or molecule to thiyl, regenerating thiol. The thiol is thus used repeatedly and a single molecule may… more
Date: March 1, 1980
Creator: Cohen, S. G.
Partner: UNT Libraries Government Documents Department
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