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Development of novel epidermal growth receptor-basedradiopharmaceuticals: Imaging agents for breast cancer

Description: The goal of this research was to develop epidermal growthfactor receptor (EGFR) nuclear medicine breast cancer imaging agents. Ourapproach was to synthesize small molecule inhibitors of the EGFR tyrosinekinase (tk) suitable for labeling with single photon or positron-emittingradioisotopes and evaluate the imaging potential of these new molecules.We have synthesized and fully characterized 22 quinazoline compounds. Allcompounds inhibit EGFR tk phosphorylation activity in the nanomolarrange. All … more
Date: September 25, 2001
Creator: Van Brocklin, Henry F.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The High Background Radiation Area in Ramsar Iran: Geology, Norm, Biology, LNT, and Possible Regulatory Fun

Description: The city of Ramsar Iran hosts some of the highest natural radiation levels on earth, and over 2000 people are exposed to radiation doses ranging from 1 to 26 rem per year. Curiously, inhabitants of this region seem to have no greater incidence of cancer than those in neighboring areas of normal background radiation levels, and preliminary studies suggest their blood cells experience fewer induced chromosomal abnormalities when exposed to 150 rem ''challenge'' doses of radiation than do the bloo… more
Date: February 25, 2002
Creator: Karam, P. Andrew
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

USING RISK-BASED CORRECTIVE ACTION (RBCA) TO ASSESS (THEORETICAL) CANCER DEATHS AVERTED COMPARED TO THE (REAL) COST OF ENVIRONMENTAL REMEDIATION

Description: In 1978, on the basis of existing health studies at the time, the Uranium Mill Tailings Remedial Action (UMTRA) Project legislation was proposed that would authorize remedial action at inactive uranium processing sites and vicinity properties. The cost of the program to the Federal Government was expected to be $180 million. With the completion of this project, approximately 1300 theoretical cancer deaths were prevented in the next 100 years at a cost of $1.45 billion, based on the Fiscal Year … more
Date: February 25, 2002
Creator: Miller, M. L. & Hylko, J. M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Receptor Specific Ligands for Spect Imaging

Description: In the past funding period we have concentrated in developing new 99mTc labeled MIBG analogs. Basic chemistry of ligand synthesis, radiochemistry of Re and 99mTc complex formation, separation of stereoisomers and in vitro stability were investigated. We have prepared a number of new MIBG derivatives containing chelating moiety N2S2 and additional groups to increase lipophilicity. Unfortunately none of the new 99mTc labeled MIBG analogs showed promise as an imaging agent for myocardial neuronal … more
Date: February 25, 2003
Creator: Kung, H. F.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Physicochemical properties and toxicities of hydrophobicpiperidinium and pyrrolidinium ionic liquids

Description: Some properties are reported for hydrophobic ionic liquids (IL) containing 1-methyl-1-propyl pyrrolidinium [MPPyrro]{sup +}, 1-methyl-1-butyl pyrrolidinium [MBPyrro]{sup +}, 1-methyl-1-propyl piperidinium [MPPip]{sup +}, 1-methyl-1-butyl piperidinium [MBPip]{sup +}, 1-methyl-1-octylpyrrolidinium [MOPyrro]{sup +} and 1-methyl-1-octylpiperidinium [MOPip]{sup +} cations. These liquids provide new alternatives to pyridinium and imidazolium ILs. High thermal stability of an ionic liquid increases sa… more
Date: June 25, 2007
Creator: Salminen, Justin; Papaiconomou, Nicolas; Kumar, R. Anand; Lee,Jong-Min; Kerr, John; Newman, John et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Superconducting Non-Scaling Ffag Gantry for Carbon-Proton Cancer Therapy

Description: We report on improvements in the non-scaling Fixed Field Alternating Gradient (FFAG) gantry design. As we previously reported, a major challenge of the carbodproton cancer therapy facilities is isocentric gantry design. The weight of the isocentric gantry transport elements in the latest Heidelberg carbon/proton facility is 135 tons. In this report we detail improvements to the previous non-scaling gantry design. We estimate that this non-scaling FFAG gantry would be almost hundred times lighte… more
Date: June 25, 2007
Creator: Trbojevic, D.; Gupta, R.; Parker, B.; Keil, E. & Sessler, A. M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

Description: Ovarian epithelial carcinomas (OEC) frequently exhibit amplifications at the 20q13 locus which is the site of several oncogenes, including the eukaryotic elongation factor EEF1A2 and the transcription factor ZNF217. We reported previously that overexpressed ZNF217 induces neoplastic characteristics in precursor cells of OEC. Unexpectedly, ZNF217, which is a transcriptional repressor, enhanced expression of eEF1A2. In this study, array comparative genomic hybridization, single nucleotide polymor… more
Date: April 25, 2008
Creator: Sun, Yu; Wong, Nicholas; Guan, Yinghui; Salamanca, Clara M.; Cheng, Jung Chien; Lee, Jonathan M. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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